Advanced 7 Tesla imaging of the knee for root cause of Osteoarthritis

先进的 7 特斯拉膝盖成像，找出骨关节炎的根本原因

• 批准号: 10586258
• 负责人: Jutta M Ellermann
• 金额: $ 55.74万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10586258
• 关键词: 3-Dimensional; Acceleration; Adoption; Anatomy; Arthritis; Bilateral; Biochemical; Biomedical Research; Blood Vessels; Brain; Cartilage; Clinical; Data; Degenerative polyarthritis; Detection; Development; Diagnostic Imaging; Disease Management; Disease Marker; Early Diagnosis; Engineering; Epidemic; Evaluation; FDA approved; Functional Imaging; Functional Magnetic Resonance Imaging; Future; Goals; Head; Hip region structure; Horns; Image; Joints; Knee; Knee Injuries; Knee bone; Knee joint; Magnetic Resonance; Magnetic Resonance Imaging; Maps; Measures; Medial meniscus structure; Medical; Meniscus structure of joint; Methodology; Methods; Minnesota; Morphology; Musculoskeletal; Musculoskeletal Diseases; Noise; Operative Surgical Procedures; Orthopedics; Outcome; Pathology; Pathway interactions; Patients; Perfusion; Pilot Projects; Predisposition; Protocols documentation; RF coil; Radial; Research; Resolution; Scheme; Signal Transduction; Sodium; Spin Labels; Surgeon; System; Techniques; Technology; Testing; Time; Tissues; Translating; Universities; Validation; Work; absorption; accurate diagnosis; anatomic imaging; arterial spin labeling; articular cartilage; bone; clinical care; clinical imaging; density; diagnostic accuracy; disability; healthy volunteer; high resolution imaging; imaging approach; imaging modality; improved; innovation; instrument; longitudinal, prospective study; magnetic field; meniscal tear; molecular marker; musculoskeletal imaging; novel; operation; protocol development; reconstruction; repaired; routine imaging; structural imaging; subchondral bone; technology development; temporal measurement; tool; translational study; transmission process

ABSTRACT: The recent FDA approval of 7T for clinical imaging of the knee, opens the possibility that this ultrahigh field MRI platform will become a more prominent tool in biomedical research and patient management. Musculoskeletal (MSK) research and diagnostic imaging have been traditionally performed at magnetic fields of 1.5 and 3T. While there is increasing availability of ultrahigh field (UHF) 7T instruments and FDA approval of 7T clinical use in the head and knee, only a fraction of the system’s true capability is being exploited. First, approval has only been given for operation in a single transmit mode configuration. As such, clinicians cannot take advantage of the available parallel transmit (pTx) functionality to integrate state-of-the-art solutions for tackling B1+ homogeneity and local SAR management. Even if available, the RF coils and optimization routines to use the pTx functionality do not exist. Second, traditional diagnostic imaging methods for evaluating the knee do not fully exploit the array of morphologic, compositional, and functional data available when performing MRI at UHF. Both the traditional and novel imaging approaches alike benefit from the increased signal-to-noise ratio at 7T. The increased sensitivity can be exploited to provide higher resolution images that are known to have a real and significant impact on diagnostic accuracy in the knee. Furthermore, certain methods are simply too compromised at lower field strengths to be obtained as part of routine imaging at 3T and below including techniques like quantitative sodium imaging and perfusion as measured through arterial spin labeling. In this proposal we focus on the engineering, methodological and protocol developments to realize the full potential of 7T knee imaging and provide a critical translational study focusing on the utility of the methods to impact clinical care. This work will be accomplished by completing four specific aims. Aim 1 will focus on the development, integration, and optimization of a pTx RF coil coil using ultrahigh dielectric constant (uHDC) material and RF management strategies to provide high-resolution morphological knee imaging methods including zero echo time imaging. Aim 2 will implement and optimizequantitative compositional and functional methods for evaluating the knee joint at 7T including T1rho andarterial spin labeling (ASL) perfusion methods. Aim 3 will involve the development and optimization of a sodium (23Na) knee coil using uHDC material and strategies for accurate quantification of 23Na concentration in the articular cartilage of the knee. Finally, the translational Aim 4, will involve a pilot study to explore the ability of the developed technologies and methods to impact patientcare. The technical developments in this proposal will advance knee imaging at 7T and likely accelerate its clinical adoption. The results of the pilot study are expected to have an immediate and important impact,by forming the basis of future longitudinal prospective studies evaluating the effects of medical treatmentson clinical outcome.

摘要： 最近FDA批准7T用于膝关节的临床成像，打开了这个领域的可能性， MRI平台将成为生物医学研究和患者管理中更重要的工具。 肌肉骨骼（MSK）的研究和诊断成像传统上是在磁 1.5和3T的场。虽然超高频（UHF）7T仪器和FDA的可用性越来越高， 尽管7T在头部和膝关节的临床使用获得批准，但该系统的真正能力只有一小部分被 被剥削首先，只批准在单一发射模式配置下运行。作为 因此，临床医生无法利用可用的并行传输（pTx）功能来集成 解决B1+同质性和局部SAR管理的最先进解决方案。即使可用， 不存在使用pTx功能的RF线圈和优化例程。二、传统诊断 用于评估膝关节的成像方法没有充分利用膝关节的形态学、组成和 在UHF下进行MRI时，功能数据可用。传统的和新的成像方法 同样受益于在7T下增加的信噪比。可以利用增加的灵敏度来 提供已知对诊断具有真实的显著影响的更高分辨率图像 膝盖的准确性。此外，某些方法在较低的场强下太过折衷 作为3T及以下常规成像的一部分获得，包括定量钠 通过动脉自旋标记测量的成像和灌注。在本提案中，我们将重点放在 工程、方法和方案开发，以实现7T膝关节成像的全部潜力 并提供了一个关键的翻译研究，重点是效用的方法，以影响临床护理。这 将通过完成四个具体目标来完成工作。目标1将侧重于发展， 使用介电常数（uHDC）材料的pTx RF线圈线圈的集成和优化， 射频管理策略提供高分辨率形态学膝关节成像方法，包括零 回波时间成像目标2将实现和优化量化的组合和功能方法， 采用T1rho和动脉自旋标记（ASL）灌注方法，在7T下对膝关节进行评价。目标3 将涉及使用uHDC材料开发和优化钠（23 Na）膝关节线圈， 准确定量膝关节软骨中23 Na浓度的策略。最后， 翻译目标4，将涉及一项试点研究，以探索开发的技术的能力， 影响病人护理的方法。该提案中的技术发展将推动膝关节成像， 7T，并可能加速其临床应用。试点研究的结果预计将立即产生 和重要的影响，通过形成未来的纵向前瞻性研究的基础， of medical医疗treatment治疗on clinical临床outcome结果.