Neuroanatomic Correlates of Language Production Characteristics After Right Hemisphere Stroke

右半球中风后语言产生特征的神经解剖学相关性

• 批准号: 10587115
• 负责人: Jamila Minga
• 金额: $ 17.47万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-01 至 2027-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10587115
• 关键词: Address; Adult; Affect; American; Area; Behavior; Behavioral; Brain; Brain Injuries; Brain region; Characteristics; Chronic Phase; Clinical; Collaborations; Communication; Communication impairment; Communities; Comprehension; Data; Databases; Development; Development Plans; Diagnosis; Diagnostic; Disease; Education; Educational workshop; Emotional; Employment; Employment Status; Evaluation; Exhibits; Family; Fostering; Future; Goals; Image; Impairment; Individual; Institution; Knowledge; Language; Language Disorders; Left; Lesion; Linguistics; Literature; Maps; Measurement; Measures; Mentored Clinical Scientist Development Program; Mentors; Methods; Modeling; Monitor; Nature; Neuroanatomy; Neurology; Outcome; Output; Patients; Pattern; Procedures; Process; Production; Productivity; Public Health; Quality of life; Quantitative Evaluations; Recovery; Research; Research Personnel; Right cerebral hemisphere; Risk; Sampling; Scientific Inquiry; Site; Social Interaction; Speech; Speech-Language Pathology; Stroke; Survivors; Symptoms; Training; Universities; Work; career; career development; clinical development; clinically relevant; cognitive neuroscience; cognitive process; comparison control; diagnostic tool; hemisphere damage; improved; indexing; information gathering; language impairment; neural; personalized diagnostics; right hemisphere brain damage; syntax; theories; therapy development

PROJECT SUMMARY/ABSTRACT Language production deficits caused by right hemisphere brain damage (RHD) are an underexplored scientific domain, despite affecting the vast majority of individuals who suffer a right hemisphere stroke. RHD patients often exhibit self-centered, inappropriate, and impolite language -- deficits that have a significant impact on their quality of life from personal relationships to employment status. Despite the devastating impact of these impairments for RHD patients and their families, very fewstudies have been undertaken to understand the nature of RHD communication differences, especially in comparison to the more obvious impairments observed after left hemisphere stroke. The current project addresses two critical knowledge gaps. First, we need a better understanding of what is wrong with the language produced by RHD patients, and second, we need to understand which right hemisphere brain areas are associatedwith which particular types of languagedeficits. These gaps will be addressed through two aims. The first aim will provide a rigorous and quantitative evaluation of the specific features of language production that are impaired following RHD, via a battery of linguistic production tasks. The second aim will involve identification of the brain areas within the right hemisphere that are associated with these deficits. Furthermore, both the behavioral and neural data will be aggregated in the burgeoning RHDBank database developed by the PI, fostering future work in this area by the scientific community at large. As PI, Dr. Minga is an early-stage career investigator with institutional support from Duke University. As a K12 award recipient, she has established a diverse mentoring team with expertise in cognitive neuroscience, neurology, speech-language pathology, and discourse corpus development. Dr. Minga’s career development plan serves to capitalize on these collaborations through workshops, seminars, and didactic training. The proposed research contributes to the growing body of knowledge concerning language production differences in adults with RHD by examining the specific indices of language production characteristics that distinguish adults with RHD and potential neuroanatomic correlates while building a corpus of imaging and language use samples for the widespread study of communication after RHD. Delineation of specific and quantifiable characteristics of language production after RHD and their relationship to lesion site(s) can foster the development of clinically relevant diagnostic measures and potential therapies.

项目总结/摘要 由右半球脑损伤（RHD）引起的语言产生缺陷是一个未充分探索的科学问题。 尽管影响了绝大多数患有右半球中风的人。RHD病人 经常表现出以自我为中心，不恰当和不礼貌的语言-这些缺陷对他们的生活有重大影响。 生活质量从人际关系到就业状况。尽管这些灾难性的影响 对于风湿性心脏病患者及其家属的损害，很少有研究已经进行了了解的性质， RHD沟通的差异，特别是在比较后观察到的更明显的障碍 左半球中风 目前的项目涉及两个关键的知识差距。首先，我们需要更好地了解什么是 第二，我们需要了解RHD患者产生的语言错误， brain脑areas区are associated关联with which哪种particular特定types类型of language语言deficits缺陷.这些差距将通过以下方式加以解决： 两个目标。第一个目标是对语言的具体特征进行严格的定量评估 通过一系列语言生产任务，RHD后受损的生产。第二个目标将 包括识别与这些缺陷相关的大脑右半球区域。 此外，行为和神经数据都将汇集在新兴的RHDBank数据库中 这是由PI开发的，促进了整个科学界在这一领域的未来工作。 作为PI，Minga博士是杜克大学机构支持的早期职业调查员。作为K12 获奖者，她建立了一个多元化的指导团队，在认知神经科学的专业知识， 神经学、言语语言病理学和话语语料库开发。Minga博士的职业发展 该计划通过讲习班、研讨会和教学培训来利用这些合作。的 拟议的研究有助于增加有关语言产生差异的知识， 通过检查区分成人的语言产生特征的具体指标， 与RHD和潜在的神经解剖学相关，同时建立成像和语言使用样本语料库 对风湿性心脏病后的交流进行广泛研究。描述特定的和可量化的特征 RHD后的语言产生及其与病变部位的关系可以促进临床 相关的诊断措施和潜在的治疗。