Injury-induced nociceptive sensitization in adult D. melanogaster
成年黑腹果蝇损伤引起的伤害性敏化
基本信息
- 批准号:10586054
- 负责人:
- 金额:$ 7.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-15 至 2023-07-07
- 项目状态:已结题
- 来源:
- 关键词:AbdomenAddressAdultAffectAgeAgingAnalgesicsAnesthesia proceduresAnimalsBehavioralBiochemicalBiological AssayBiological MetamorphosisBiological ModelsBone Morphogenetic ProteinsCandidate Disease GeneChronicDoseDrosophila genusEmotionalEpidemicExhibitsExposure toFutureGenesGeneticGenetic ModelsGenomeGoalsHealth PromotionHumanHypersensitivityInjuryIntractable PainInvestigationKnowledgeLarvaLasersLateralLifeLongevityMammalsMapsMeasuresMechanicsMediatingMethodsModelingMolecularMorphologyNeuronsNociceptionNociceptorsOpiate AddictionOpioidOrthologous GenePainPain ResearchPain managementPathway interactionsPharmaceutical PreparationsPopulationProcessProtocols documentationQuality of lifeReactionRecoveryResolutionResponse LatenciesRodentRoleSeveritiesSex DifferencesSignal TransductionSignaling ProteinStimulusSystemTestingTimeTissuesTranslatingTranslationsUV injuryUltraviolet RaysVacuumaddiction liabilityage effectallodyniaavoidance behaviorchronic painchronic pain managementeconomic impactexperimental studyflygene conservationgene discoveryhealinghealth warninghuman diseaseinjuredinnovationmature animalneurophysiologynew therapeutic targetnovelpain modelpain reductionperipheral painpower analysisresponserestraintsexside effectyoung adult
项目摘要
Project Summary
Normal pain promotes health by warning us of potential tissue damage, but abnormal pain reduces the quality
of life for millions around the world. Pain sensitization after injury also promotes health by reducing re-injury
during healing. Some types of abnormal pain, including chronic pain, result from dysregulation of the pain
sensitization system. Available treatment for chronic pain is inadequate, in part because the deleterious side
effects of our best analgesics, the opioids, are made more hazardous by longer use. Better treatments for
abnormal pain are badly needed. We propose to reveal novel targets for pain medications by exploiting the
powerful genetic toolkit of the Drosophila model. When the fruit fly is injured by a controlled dose of ultraviolet
(UV) radiation, the animal exhibits allodynia, a manifestation of nociceptive sensitization. This means that the
injured animal will react with a nocifensive avoidance behavior in the form of an avoidance 'jump', in response
to a thermal stimulus with a reduced delay, compared with uninjured animals. This injury induced sensitization
paradigm has previously been used in larval flies to demonstrate that the nociceptor neuron requires signaling
by the Bone Morphogenetic Proteins (BMP) pathway to produce allodynia. BMP signaling components in the
fly are very similar to their mammalian orthologs. However, studies on larval flies are limited to the short time
available before the larva pupariates, becoming insensitive while metamorphosis reorganizes the larval tissues
to produce an adult. This project seeks to establish similar methods that can be applied to adult flies, which
live for 35 or more days, a much longer time window for studying processes like chronic pain. Preliminary
results indicate that UV-injured adults, like larvae, do indeed become hypersensitive to noxious stimuli. We are
now ready to map out the time required for injured adults to become sensitized and then return to normal
sensitivity, so that we can test the roles of genes that my serve to prolong pain sensitization, while others may
shorten the hypersensitive period. The roles of sex and aging in pain sensitization will also be examined.
Because of the high degree of functional conservation between fly and mammalian genes, components
identified by these experiments may represent targets for novel medications for the treatment of abnormal pain
in humans.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
GEOFFREY GANTER其他文献
GEOFFREY GANTER的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('GEOFFREY GANTER', 18)}}的其他基金
Investigation of Armadillo/ß-catenin Mechanisms Influencing Nociceptive Sensitivity in Drosophila
影响果蝇伤害感受敏感性的犰狳/α-连环蛋白机制的研究
- 批准号:
10653377 - 财政年份:2023
- 资助金额:
$ 7.1万 - 项目类别:
Injury-induced nociceptive sensitization in adult D. melanogaster
成年黑腹果蝇损伤引起的伤害性敏化
- 批准号:
10431101 - 财政年份:2022
- 资助金额:
$ 7.1万 - 项目类别:
Characterization of the BMP signaling pathways that produce nociceptor sensitization in Drosophila
果蝇中产生伤害感受器敏化的 BMP 信号通路的表征
- 批准号:
9022858 - 财政年份:2015
- 资助金额:
$ 7.1万 - 项目类别:
Characterization of the signaling pathways that produce nociceptor sensitization in Drosophila
果蝇中产生伤害感受器敏化的信号通路的表征
- 批准号:
10046777 - 财政年份:2015
- 资助金额:
$ 7.1万 - 项目类别:
Ecdysone modulation of sexual behavior in Drosophila melanogaster
蜕皮激素对黑腹果蝇性行为的调节
- 批准号:
7913520 - 财政年份:2009
- 资助金额:
$ 7.1万 - 项目类别:
Ecdysone modulation of sexual behavior in Drosophila melanogaster
蜕皮激素对黑腹果蝇性行为的调节
- 批准号:
7456750 - 财政年份:2008
- 资助金额:
$ 7.1万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 7.1万 - 项目类别:
Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 7.1万 - 项目类别:
Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 7.1万 - 项目类别:
Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 7.1万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 7.1万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 7.1万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 7.1万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 7.1万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 7.1万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 7.1万 - 项目类别:
Research Grant