Stereospecific Cross-Coupling Reactions as a Tool for Three Dimensional Molecular Diversification

立体特异性交叉偶联反应作为三维分子多样化的工具

基本信息

  • 批准号:
    10586673
  • 负责人:
  • 金额:
    $ 24.81万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-09-15 至 2027-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Using enantioenriched organometallic nucleophiles in transition metal-catalyzed carbon-carbon bond-forming reactions, we aim to develop general tools for the rational manipulation of three- dimensional molecular structure. By introducing absolute stereochemistry prior to the formation of a final stereogenic center, and reliably transferring this stereochemistry via stereoretentive or stereoinvertive cross-coupling processes, the rapid preparation of diverse libraries of single- enantiomer drug candidates for use in biological assays will be achievable. The use of enantioenriched secondary alkylboron and alkylstannane nucleophiles will be explored in Pd- and Cu-catalyzed alkyl-aryl and alkyl-alkyl cross-coupling reactions, with particular focus on the derivatization of medicinally relevant organic frameworks and chiral structural motifs that are currently inaccessible but are of biological or pharmaceutical interest.
项目总结/文摘

项目成果

期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A General Approach to Stereospecific Cross-Coupling Reactions of Nitrogen-Containing Stereocenters
  • DOI:
    10.1016/j.chempr.2020.02.002
  • 发表时间:
    2020-03-12
  • 期刊:
  • 影响因子:
    23.5
  • 作者:
    Ma, Xinghua;Zhao, Haoran;Biscoe, Mark R.
  • 通讯作者:
    Biscoe, Mark R.
A general approach to stereospecific Pd-catalyzed cross-coupling reactions of benzylic stereocenters.
  • DOI:
    10.1039/d3sc04519f
  • 发表时间:
    2023-12-13
  • 期刊:
  • 影响因子:
    8.4
  • 作者:
    Binayeva, Meruyert;Ma, Xinghua;Ghaemimohammadi, Pejman;Biscoe, Mark R.
  • 通讯作者:
    Biscoe, Mark R.
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Mark Roger Biscoe其他文献

Mark Roger Biscoe的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Mark Roger Biscoe', 18)}}的其他基金

Stereospecific cross-coupling reactions as a tool for three-dimensional molecular diversification
立体特异性交叉偶联反应作为三维分子多样化的工具
  • 批准号:
    10163211
  • 财政年份:
    2018
  • 资助金额:
    $ 24.81万
  • 项目类别:
Stereospecific cross-coupling reactions as a tool for three-dimensional molecular diversification
立体特异性交叉偶联反应作为三维分子多样化的工具
  • 批准号:
    9975863
  • 财政年份:
    2018
  • 资助金额:
    $ 24.81万
  • 项目类别:
The Use of Optically-Active Nucleophiles in Metal-Catalyzed Coupling Reactions
光学活性亲核试剂在金属催化偶联反应中的应用
  • 批准号:
    8828719
  • 财政年份:
    2014
  • 资助金额:
    $ 24.81万
  • 项目类别:
The Use of Optically-Active Nucleophiles in Metal-Catalyzed Coupling Reactions
光学活性亲核试剂在金属催化偶联反应中的应用
  • 批准号:
    8667099
  • 财政年份:
    2014
  • 资助金额:
    $ 24.81万
  • 项目类别:
Metal-Catalyzed Cross-Coupling Reactions Using Optically-Active Nucleophiles
使用光学活性亲核试剂的金属催化交叉偶联反应
  • 批准号:
    8286884
  • 财政年份:
    2011
  • 资助金额:
    $ 24.81万
  • 项目类别:
Metal-Catalyzed Cross-Coupling Reactions Using Optically-Active Nucleophiles
使用光学活性亲核试剂的金属催化交叉偶联反应
  • 批准号:
    8461142
  • 财政年份:
    2011
  • 资助金额:
    $ 24.81万
  • 项目类别:
Metal-Catalyzed Cross-Coupling Reactions Using Optically-Active Nucleophiles
使用光学活性亲核试剂的金属催化交叉偶联反应
  • 批准号:
    8078467
  • 财政年份:
    2011
  • 资助金额:
    $ 24.81万
  • 项目类别:
Using Fluorophobicity in Pd-catalyzed C-O Couplings
在 Pd 催化的 C-O 偶联中利用疏氟性
  • 批准号:
    7128119
  • 财政年份:
    2005
  • 资助金额:
    $ 24.81万
  • 项目类别:
Using Fluorophobicity in Pd-catalyzed C-O Couplings
在 Pd 催化的 C-O 偶联中利用疏氟性
  • 批准号:
    7281739
  • 财政年份:
    2005
  • 资助金额:
    $ 24.81万
  • 项目类别:
Using Fluorophobicity in Pd-catalyzed C-O Couplings
在 Pd 催化的 C-O 偶联中利用疏氟性
  • 批准号:
    6999949
  • 财政年份:
    2005
  • 资助金额:
    $ 24.81万
  • 项目类别:

相似海外基金

System Architecture of Impact-Resistant Robot with Detection and Prevention of Joint Dislocation Inspired from Biological Intra-Articular Proprioception
受生物关节内本体感觉启发的关节脱位检测与预防的抗冲击机器人系统架构
  • 批准号:
    22K17973
  • 财政年份:
    2022
  • 资助金额:
    $ 24.81万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Perturbation of the extracellular architecture to promote the absorption and lymphatic transport of biological macromolecules
扰动细胞外结构促进生物大分子的吸收和淋巴转运
  • 批准号:
    LP140100377
  • 财政年份:
    2015
  • 资助金额:
    $ 24.81万
  • 项目类别:
    Linkage Projects
TRR 141: Biological Design and Integrative Structures. Analysis, Simulation and Implementation in Architecture
TRR 141:生物设计和综合结构。
  • 批准号:
    231064407
  • 财政年份:
    2014
  • 资助金额:
    $ 24.81万
  • 项目类别:
    CRC/Transregios
Evolutionary processes driving biological variation and diversity as models for exploratory digital design tools in architecture (B02)
驱动生物变异和多样性的进化过程作为建筑探索性数字设计工具的模型(B02)
  • 批准号:
    260974942
  • 财政年份:
    2014
  • 资助金额:
    $ 24.81万
  • 项目类别:
    CRC/Transregios
Collaborative Research: ABI: Innovation: The Global Names Architecture, an infrastructure for unifying taxonomic databases and services for managers of biological information.
合作研究:ABI:创新:全球名称架构,一个为生物信息管理者统一分类数据库和服务的基础设施。
  • 批准号:
    1342595
  • 财政年份:
    2013
  • 资助金额:
    $ 24.81万
  • 项目类别:
    Continuing Grant
Collaborative Research: ABI: Innovation: The "Global Names Architecture," an infrastructure for unifying taxonomic databases and services for managers of biological information.
合作研究:ABI:创新:“全球名称架构”,一个为生物信息管理者统一分类数据库和服务的基础设施。
  • 批准号:
    1062324
  • 财政年份:
    2011
  • 资助金额:
    $ 24.81万
  • 项目类别:
    Continuing Grant
Collaborative Research: ABI: Innovation: The Global Names Architecture, an infrastructure for unifying taxonomic databases and services for managers of biological information.
合作研究:ABI:创新:全球名称架构,一个为生物信息管理者统一分类数据库和服务的基础设施。
  • 批准号:
    1062387
  • 财政年份:
    2011
  • 资助金额:
    $ 24.81万
  • 项目类别:
    Continuing Grant
ABI:Innovation: Collaborative Research: The "Global Names Architecture," an infrastructure for unifying taxonomic databases and services for managers of biological information.
ABI:创新:协作研究:“全球名称架构”,一种为生物信息管理者统一分类数据库和服务的基础设施。
  • 批准号:
    1062378
  • 财政年份:
    2011
  • 资助金额:
    $ 24.81万
  • 项目类别:
    Continuing Grant
Collaborative Research: ABI: Innovation: The Global Names Architecture, an infrastructure for unifying taxonomic databases and services for managers of biological information
合作研究:ABI:创新:全球名称架构,为生物信息管理者统一分类数据库和服务的基础设施
  • 批准号:
    1062441
  • 财政年份:
    2011
  • 资助金额:
    $ 24.81万
  • 项目类别:
    Continuing Grant
Biophysics of cryopreservation: elucidating the structural architecture and physical mechanisms of both model and complex biological systems
冷冻保存的生物物理学:阐明模型和复杂生物系统的结构体系和物理机制
  • 批准号:
    EP/H020616/1
  • 财政年份:
    2010
  • 资助金额:
    $ 24.81万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了