Stereospecific Cross-Coupling Reactions as a Tool for Three Dimensional Molecular Diversification
立体特异性交叉偶联反应作为三维分子多样化的工具
基本信息
- 批准号:10586673
- 负责人:
- 金额:$ 24.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-15 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalArchitectureBiologicalBiological AssayCarbonChemicalsCouplingDerivation procedureDevelopmentLibrariesMedicineMethodsMolecularMolecular StructurePharmacologic SubstancePreparationPrincipal InvestigatorProcessReactionResearchStructureTechniquesTestingTransition ElementsWorkdrug candidatedrug discoveryenantiomerinterestnovel therapeuticsstereochemistrythree dimensional structuretool
项目摘要
PROJECT SUMMARY/ABSTRACT
Using enantioenriched organometallic nucleophiles in transition metal-catalyzed carbon-carbon
bond-forming reactions, we aim to develop general tools for the rational manipulation of three-
dimensional molecular structure. By introducing absolute stereochemistry prior to the formation
of a final stereogenic center, and reliably transferring this stereochemistry via stereoretentive or
stereoinvertive cross-coupling processes, the rapid preparation of diverse libraries of single-
enantiomer drug candidates for use in biological assays will be achievable. The use of
enantioenriched secondary alkylboron and alkylstannane nucleophiles will be explored in Pd-
and Cu-catalyzed alkyl-aryl and alkyl-alkyl cross-coupling reactions, with particular focus on the
derivatization of medicinally relevant organic frameworks and chiral structural motifs that are
currently inaccessible but are of biological or pharmaceutical interest.
项目总结/文摘
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A General Approach to Stereospecific Cross-Coupling Reactions of Nitrogen-Containing Stereocenters
- DOI:10.1016/j.chempr.2020.02.002
- 发表时间:2020-03-12
- 期刊:
- 影响因子:23.5
- 作者:Ma, Xinghua;Zhao, Haoran;Biscoe, Mark R.
- 通讯作者:Biscoe, Mark R.
A general approach to stereospecific Pd-catalyzed cross-coupling reactions of benzylic stereocenters.
- DOI:10.1039/d3sc04519f
- 发表时间:2023-12-13
- 期刊:
- 影响因子:8.4
- 作者:Binayeva, Meruyert;Ma, Xinghua;Ghaemimohammadi, Pejman;Biscoe, Mark R.
- 通讯作者:Biscoe, Mark R.
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Mark Roger Biscoe其他文献
Mark Roger Biscoe的其他文献
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{{ truncateString('Mark Roger Biscoe', 18)}}的其他基金
Stereospecific cross-coupling reactions as a tool for three-dimensional molecular diversification
立体特异性交叉偶联反应作为三维分子多样化的工具
- 批准号:
10163211 - 财政年份:2018
- 资助金额:
$ 24.81万 - 项目类别:
Stereospecific cross-coupling reactions as a tool for three-dimensional molecular diversification
立体特异性交叉偶联反应作为三维分子多样化的工具
- 批准号:
9975863 - 财政年份:2018
- 资助金额:
$ 24.81万 - 项目类别:
The Use of Optically-Active Nucleophiles in Metal-Catalyzed Coupling Reactions
光学活性亲核试剂在金属催化偶联反应中的应用
- 批准号:
8828719 - 财政年份:2014
- 资助金额:
$ 24.81万 - 项目类别:
The Use of Optically-Active Nucleophiles in Metal-Catalyzed Coupling Reactions
光学活性亲核试剂在金属催化偶联反应中的应用
- 批准号:
8667099 - 财政年份:2014
- 资助金额:
$ 24.81万 - 项目类别:
Metal-Catalyzed Cross-Coupling Reactions Using Optically-Active Nucleophiles
使用光学活性亲核试剂的金属催化交叉偶联反应
- 批准号:
8286884 - 财政年份:2011
- 资助金额:
$ 24.81万 - 项目类别:
Metal-Catalyzed Cross-Coupling Reactions Using Optically-Active Nucleophiles
使用光学活性亲核试剂的金属催化交叉偶联反应
- 批准号:
8461142 - 财政年份:2011
- 资助金额:
$ 24.81万 - 项目类别:
Metal-Catalyzed Cross-Coupling Reactions Using Optically-Active Nucleophiles
使用光学活性亲核试剂的金属催化交叉偶联反应
- 批准号:
8078467 - 财政年份:2011
- 资助金额:
$ 24.81万 - 项目类别:
Using Fluorophobicity in Pd-catalyzed C-O Couplings
在 Pd 催化的 C-O 偶联中利用疏氟性
- 批准号:
7128119 - 财政年份:2005
- 资助金额:
$ 24.81万 - 项目类别:
Using Fluorophobicity in Pd-catalyzed C-O Couplings
在 Pd 催化的 C-O 偶联中利用疏氟性
- 批准号:
7281739 - 财政年份:2005
- 资助金额:
$ 24.81万 - 项目类别:
Using Fluorophobicity in Pd-catalyzed C-O Couplings
在 Pd 催化的 C-O 偶联中利用疏氟性
- 批准号:
6999949 - 财政年份:2005
- 资助金额:
$ 24.81万 - 项目类别:
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