Regulation of glycogen in health and disease

项目总结/摘要 毫无疑问，我们正处于肥胖、糖尿病和脂肪肝的全球流行之中， 能量平衡的破坏是这些疾病的核心。能源储存的第一个选择， 在代谢活性组织如肝脏、脂肪和肌肉中利用的是糖原。我们建议 糖原代谢的调节由复杂的反馈和前馈途径组成，因此， 糖原本身在肝脏和脂肪组织中能量分布的总体控制中起主要作用。 糖原代表了两种组织中能量储存和利用的首选，但也作为一种代谢产物。 在生理和病理状态下的代谢调节剂，指导细胞利用或储存能量。在 在肝细胞中，糖原通过AMPK途径的变化触发脂肪生成;而在脂肪细胞中，糖原 周转对于响应于冷的产热反应是至关重要的。我们将用两个假设来探讨这些假设。 该项目的目标是关注肝脏和脂肪细胞中的这些关键途径，希望开发新的治疗方法。 这些毁灭性的疾病。

Project Summary/Abstract There is little doubt that we are in the midst of a worldwide epidemic of obesity, diabetes and fatty liver disease, and disruptions in energy balance are at the heart of these disorders. The first option for energy storage and utilization in metabolically active tissues such as liver, fat and muscle is glycogen. We propose that the regulation of glycogen metabolism is comprised of complex feedback and feedforward pathways, and as such, glycogen itself plays a major role in the overall control of energy disposition in liver and adipose tissue. Glycogen represents the first choice for energy storage and utilization in both tissues, but also serves as a modulator of metabolism in physiological and pathological states, directing the cell to utilize or store energy. In hepatocytes, glycogen triggers lipogenesis via changes in the AMPK pathway; while in adipocytes glycogen turnover is crucial for thermogenic responses in response to cold. We will explore these hypotheses with two aims that focus on these crucial pathways in liver and fat cells, hoping to develop new approaches to therapies for these devastating diseases.