Basic Science Core - Biosafety & Biocontainment Core (BBC)

基础科学核心 - 生物安全

• 批准号: 10588216
• 负责人: Jordi B Torrelles
• 金额: $ 17.38万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-10 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10588216
• 关键词: Accidents; Address; Aerosols; Antibiotics; Basic Science; Bioenergetics; Biomedical Research; Blood; Cell Separation; Clinical; Containment; Decontamination; Drug resistant Mycobacteria Tuberculosis; Educational Curriculum; Electron Spin Resonance Spectroscopy; Emergency Situation; Emergency response; Emerging Technologies; Ensure; Environment; Equipment; Genomics; Genus Hippocampus; Goals; Immunohistochemistry; In Vitro; Infection; Infectious Agent; Knowledge; Laboratories; Learning; Maintenance; Measures; Medical emergency; Metabolic; Methods; Mycobacterium tuberculosis; Mycobacterium tuberculosis complex; Oral; PET/CT scan; Participant; Phase; Predisposition; Procedures; Research; Research Institute; Research Personnel; Resource-limited setting; Risk; Risk Assessment; Rodent; Safety; Source; Techniques; Texas; Training; Training Programs; Training Technics; Tuberculosis; Work; Writing; X-Ray Computed Tomography; biocontainment facility; biosafety level 3 facility; career; cellular imaging; co-infection; cytate; design; experience; experimental study; hazard; in vivo; in vivo imaging system; innovation; knowledgebase; laboratory experience; man-made disasters; microscopic imaging; multidisciplinary; new technology; next generation; nonhuman primate; operation; personal protective equipment; programs; response; risk mitigation; skills; success

Texas Biomed IN-TRAC Biosafety & Biocontainment Core (BBC) – ABSTRACT The goal of this core is to establish a personalized Biosafety & Biocontainment training curriculum for the next generation of tuberculosis (TB) researchers in order to prepare them to work and excel within the biocontainment environment performing studies to advance the field. For a new investigator pursuing TB research as well as for well-established investigators who want to enter the TB research field, it is critical for them to understand biosafety and the biocontainment environment, including knowledge of the strengths and limitations of working in biocontainment, in order for them to achieve their career goals. The ability to properly conduct risk assessment including a thorough understanding of equipment and procedures in biocontainment, will further ensure innovations in TB research, especially in resource limited areas. Our Aims are to: Aim 1. Establish and manage a personalized Biosafety & Biocontainment curriculum. In this Aim a phased approach (assessment and didactic phases) will be implemented to provide comprehensive and customized training. Aim 2. Execute a Biosafety & Biocontainment training program for IN-TRAC participants. In this aim, a personalized Biocontainment training program established for each IN-TRAC participant will be executed. Participants will learn how to function safely and effectively in a high-containment BSL3 facility. We will divide this into three segments: Biocontainment facility operations, General Procedures and Emergency Response Drills. Aim 3. Apply risk assessment and mitigation strategies to emerging technology and multi-hazard scenarios. New technology often introduces unforeseeable biosafety risks. Equipped with general biocontainment and M.tb procedure-specific knowledge, participants will be able to properly evaluate and implement procedures when encountering emerging technology and develop procedures to safety achieve their research goals. Upon completion of this core curriculum, new TB researchers will be prepared/proficient in working in a biocontainment environment, including general and specialized techniques required for success in the TB field. Importantly, IN-TRAC participants will prepare a written and oral summary about the strengths and weaknesses of experience for the IN-TRAC program.

德克萨斯州BioMed Trac In-Trac Biosafety＆Biocontainment Winerment Core（BBC） - 摘要 该核心的目的是为下一个建立个性化的生物安全和生物内在培训课程 结核病（TB）研究人员的生成，以便他们准备工作并在生物培养中表现出色 进行研究以推进领域的环境。为了进行结核病研究的新调查员以及 想要进入结核病研究领域的成熟的调查人员，对他们来说至关重要 生物安全和生物内在环境，包括了解工作的优势和局限性 在生物植物中，为了使他们实现自己的职业目标。正确进行风险评估的能力 包括对生物内在的设备和程序的透彻理解，将进一步确保 结核病研究的创新，尤其是在资源有限领域。我们的目标是：目标1。建立和管理 个性化的生物安全和生物内在课程。在此目标中，一种分阶段的方法（评估和 教学阶段将实施以提供全面和定制的培训。目标2。执行 针对潮过程参与者的生物安全与生物疗养培训计划。在这个目标中，个性化 将执行针对每个TRAC参与者建立的生物娱乐培训计划。参与者会 了解如何在高控制BSL3设施中安全有效地运作。我们将将其分为三 细分市场：生物培养设施操作，一般程序和应急演习。目标3。 将风险评估和缓解策略应用于新兴技术和多危险场景。 新技术通常会引入不可预见的生物安全风险。配备了一般生物内在和M.TB 特定于程序的知识，参与者将能够正确评估和实施程序 遇到新兴技术并制定安全程序以实现其研究目标。 完成本核心课程后，新的结核病研究人员将准备/精通A 生物内在环境，包括在结核病领域成功所需的一般和专业技术。 重要的是，贸易中的参与者将准备有关优点和劣势的书面和口头摘要 Trac In-trac计划的经验。