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Basic Science Core - Imaging

基础科学核心 - 成像

基本信息

批准号：
10588228
负责人：
Deepak Kaushal
金额：
$ 13.33万
依托单位：
TEXAS BIOMEDICAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-10 至 2027-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10588228
关键词：
Address Animal Model Animals Basic Science Biology Biomedical Research Caring Cell Separation Cells Cellular Immunology Cities Clinical Clinical Management Clinical Services Collaborations Communication Communities Complement Computational algorithm Computer Analysis Confocal Microscopy Containment Data Disadvantaged Discipline Educational Curriculum Equipment Evaluation Experimental Designs Flow Cytometry Fluorescent in Situ Hybridization Fluorochrome Freezing Funding Funding Agency Genomics Goals Health Professional Image Image Analysis Immunofluorescence Immunologic Inpatients Institution Knowledge Label Laboratories Lasers Leadership Learning Light Magnetic Resonance Imaging Mexico Microscopy Molecular Optics Outpatients Paraffin Participant Positron-Emission Tomography Primates Publishing RNA Recording of previous events Research Research Institute Research Personnel Resources Robotics Rodent Science Scientist Services Sorting Structure System Techniques Testing Texas Thick Tissues Training Training Programs Tuberculosis United States National Institutes of Health Work X-Ray Computed Tomography animal safety biocontainment facility cohort confocal imaging cytate design experience high dimensionality imaging capabilities imaging modality imaging platform imaging study in vivo imaging system live cell imaging microscopic imaging multidisciplinary next generation optical imaging peer prevent programs prospective skills tomography tool whole animal imaging

项目摘要

TEXAS BIOMED IN-TRAC Research Imaging Core ABSTRACT The Research Imaging Core will leverage key strengths of Texas Biomed, namely a strong cohort of NIH- funded TB investigators with a history of collaboration and with experience in different imaging platforms. IN- TRAC participants will benefit from access to unique NHP resources in the Southwest National Primate Research Center (SNPRC) and its cutting edge imaging capabilities. The Research Imaging Core will also establish an education curriculum to introduce IN-TRAC participants to a variety of cell-based and whole animal imaging platforms. AIM 1: Provide didactic and hands-on training program in confocal microscopy and optical imaging. IN-TRAC participants will learn multi-label immunofluorescence or fluorescence in-situ hybridization (FISH) confocal microscopy, which allows for 3- or 4-D evaluation of tissues and cells with multiple fluorochrome labels. AIM 2. Provide didactic and hands-on training in cutting-edge cellular immunology techniques requiring imaging support or computational analysis. The Texas Biomed Biology, Microscopy and Molecular Cores provide high-dimensional, multi-parameter flow cytometry and analysis as well as BSL3 sorting capabilities. Established TB researchers will provide training live cell imaging (Cytation 5) and scRNAseq (10x Genomics) in BSL3. AIM 3: Provide didactic and hands-on training in live imaging using PET/CT and IVIS systems. Training in whole-body live Positron Emission Tomography (PET) and X-ray Computed Tomography (CT) imaging of NHP and in-vivo imaging system (IVIS) of rodents within the BSL3. IN-TRAC participants will extern at the NHP MRI facilities at UTHSCA to learn the advantages and limitations of this imaging platform. At the completion of the Research Imaging Core, participants will be able to effectively interpret published data that use imaging modalities for NHP, rodents, tissues, cells and RNA; design experiments to test their own hypothesis; and participate in TB research that uses the appropriate animal model.

德克萨斯生物医学研究成像核心摘要