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Baboon model of long term effects of SARS-CoV-2 infection

Baboon model of long term effects of SARS-CoV-2 infection
SARS-CoV-2 感染长期影响的狒狒模型
批准号：
10413419
负责人：
Deepak Kaushal
金额：
$49.97万
依托单位：
TEXAS BIOMEDICAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
项目状态：
未结题
起止时间：
2021-06-01 至 2026-04-30
来源：
https://reporter.nih.gov/project-details/10413419
关键词：
2019-nCoVAddressAgeAlveolarAnimalsAutopsyBiological AssayBloodBrainCOVID-19COVID-19 susceptibilityCOVID-19 therapeuticsCallithrixCallithrix jacchus jacchusCellsClinicalCollaborationsComplexConfocal MicroscopyDiseaseEventExhibitsFlow CytometryHealthHeartHistopathologyHuman ResourcesImageImmuneImmunologyIn Situ HybridizationInfectionInterferon Type IKidneyLearningLesionLiverLong COVIDLong-Term EffectsLongitudinal StudiesLungMacacaMacaca mulattaModelingMorbidity - disease rateMyeloid CellsNoseOralOrganPapioPathologicPathologyPneumoniaProteinsPulmonary InflammationPulmonary PathologyPulmonary function testsRNAReportingRouteSARS-CoV-2 infectionSARS-CoV-2 pathogenesisSkinSwabSymptomsTherapeuticThoracic RadiographyTimeTissuesViralVirusVirus DiseasesVirus ReplicationWashingtonWidespread DiseaseX-Ray Computed Tomographybasecomparativecostcytokinecytokine release syndromeexperimental studyinfectious disease modelinflammatory milieuinterstitiallung imagingnonhuman primatepulmonary functionrectalresponseserial imagingsexsingle-cell RNA sequencingsystemic inflammatory responsetranscriptome sequencingvaccine evaluation

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英文摘要
Abstract. Nonhuman primate (NHP) models of SARS-CoV-2 infection showed mostly mild disease. Infection of old-world origin baboons however showed moderate disease especially with significantly more lung pathology and evidence of viral dissemination to extrapulmonary tissues. Baboons are therefore an important model to study the pathogenesis of SARS-CoV-2 infection and identify therapeutic approaches to control COVID-19. We hypothesize that a study of long term effects of COVID-19 in the lung and other compartments is therefore best studied in a model like baboon. Here we propose experiments to address this issue.
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会议论文
Role of Inducible Bronchus Associated Lymphoid Tissue in Latent Tuberculosis
  • 批准号：
    10764569
  • 项目类别：
  • 资助金额：
    $141.57万
  • 财政年份：
    2023
  • 负责人：
    Deepak Kaushal
  • 依托单位：
    UNIVERSITY OF CHICAGO
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