Basic Science Core - Animal models

基础科学核心 - 动物模型

• 批准号: 10588223
• 负责人: Shannan Hall-Ursone
• 金额: $ 13.81万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-10 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10588223
• 关键词: Address; Animal Experimentation; Animal Model; Animals; Basic Science; Biomedical Research; Chest; Cities; Clinic; Clinical; Clinical Management; Clinical Services; Communicable Diseases; Communication; Communities; Complement; Country; Data; Development; Discipline; Drug Screening; Ebola; Education; Experimental Designs; Foundations; Funding Agency; HIV; Health; Health Professional; Hepatitis Viruses; Human; In Vitro; Inpatients; Knowledge; Leadership; Mexico; Mission; Modeling; Molecular Biology; Mus; Outpatients; Participant; Pathogenesis; Pertussis; Primates; Publishing; Research; Research Institute; Research Personnel; Resources; Rodent; Science; Structure; System; Testing; Texas; Training; Training Programs; Translating; Tuberculosis; Tuberculosis Vaccines; Universities; Work; ZIKA; biocontainment facility; design; experience; externship; imaging platform; in silico; metropolitan; mouse model; multidisciplinary; next generation; nonhuman primate; novel therapeutics; novel vaccines; peer; prevent; programs; prospective; skills; success; theories; tool

IN-TRAC ANIMAL CORE ABSTRACT The Animal Model Core will establish a training program to introduce all IN-TRAC participants to the TB field using a variety of animal models that can translate in silico and in vitro findings into potential application to humans. Texas Biomed hosts the Southwest National Primate Research Center (SNPRC) and has developed large NHP programs that incorporate aerobiology, molecular biology and a variety of imaging platforms within the Animal Biosafety Level 3 (ABSL3). These will be the foundation of the Animal Core. SPECIFIC AIM 1: Conduct an educational program in the use of animals for research, and alternatives. The use of animals in research requires consideration of the three R’s (reduction, replacement, refinement). All IN-TRAC participants will receive training in the considerations of the three R’s during experimental design, selection of appropriate models to test their specific hypothesis, and the alternate systems available or in development for the replacement of animals in biomedical research. SPECIFIC AIM 2: Leveraging the mouse model of TB to study pathogenesis and testing of new therapies and vaccines. The mouse model has been a mainstay for TB research and remains a useful tool for understanding TB immuno-pathogenesis and for screening drugs and vaccines for TB. IN-TRAC participants will be introduced to a variety of mouse resources available for TB research, and will be trained in theory and practice of how to design and conduct studies using rodents, and how to interpret experimental data with scientific rigor. SPECIFIC AIM 3: Leveraging the NHP model of TB to study pathogenesis and testing of new therapies and vaccines. Texas Biomed has a unique resource in the SNPRC that can provide IN-TRAC participants with an in depth training in the use of NHPs in TB research. IN- TRAC participants will be introduced to a variety of NHP resources available for TB research, and train in theory and practice of how to design and conduct studies using NHPs, and how to interpret experimental data with scientific rigor. At the completion of the Animal Model Core, participants will be able to effectively interpret published data that use rodents and NHP (and other animal models, in part through externships), design experiments to test their own hypothesis, and participate in TB research that uses animals.

IN-TRAC 动物核心摘要 动物模型核心将建立一个培训计划，向所有 IN-TRAC 参与者介绍结核病领域 使用各种动物模型，可以将计算机和体外研究结果转化为潜在的应用 人类。德克萨斯生物医学中心拥有西南国家灵长类动物研究中心 (SNPRC)，并开发了 大型 NHP 项目，其中包含空气生物学、分子生物学和各种成像平台 动物生物安全等级 3 (ABSL3)。这些将成为动物核心的基础。具体目标 1： 开展有关使用动物进行研究和替代方案的教育计划。动物的利用 研究中需要考虑三个R（reduction、replacement、refinement）。所有 IN-TRAC 参与者 将接受在实验设计、选择适当的方法期间考虑三个 R 的培训 模型来测试他们的具体假设，以及可用或正在开发的替代系统 在生物医学研究中替代动物。具体目标 2：利用 TB 小鼠模型 研究发病机制以及新疗法和疫苗的测试。小鼠模型一直是 结核病研究仍然是了解结核病免疫发病机制以及筛选药物和药物的有用工具 结核病疫苗。 IN-TRAC 参与者将了解各种可用于结核病的鼠标资源 研究，并将接受有关如何使用啮齿动物设计和进行研究的理论和实践培训，以及如何 以科学严谨的方式解释实验数据。具体目标 3：利用结核病 NHP 模型进行研究 发病机制以及新疗法和疫苗的测试。德克萨斯生物医学公司在以下领域拥有独特的资源： SNPRC 可以为 IN-TRAC 参与者提供在结核病研究中使用 NHP 的深入培训。在- TRAC 参与者将了解可用于结核病研究的各种 NHP 资源，并进行理论培训 以及如何使用 NHP 设计和进行研究的实践，以及如何解释实验数据 科学严谨。完成动物模型核心课程后，参与者将能够有效地解释 发表了使用啮齿动物和 NHP（以及其他动物模型，部分通过实习）的数据，设计 实验来检验自己的假设，并参与使用动物的结核病研究。