An Evaluation of Neurobiological Similarities of Tinnitus and PTSD

耳鸣和创伤后应激障碍的神经生物学相似性评估

• 批准号: 10588230
• 负责人: John Moring
• 金额: $ 16.81万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-04 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10588230
• 关键词: Air; Attention; Audiology; Auditory; Behavioral; Behavioral Symptoms; Brain; Cambodian; Clinic; Clinical; Clinical Trials; Cognition; Data; Development; Disease; Distress; Evaluation; Familiarity; Functional Magnetic Resonance Imaging; Future; Goals; Healthcare Systems; Hearing; Hearing problem; Impairment; Individual; Knowledge; Loudness; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentors; Modeling; Moods; Neurobehavioral Manifestations; Neurobiology; Neurologic; Noise; Participant; Pattern; Phenotype; Positioning Attribute; Post-Traumatic Stress Disorders; Protocols documentation; Psychologist; Psychometrics; Psychosocial Assessment and Care; Psychosocial Factor; Refugees; Reporting; Research; Research Personnel; Rest; Sampling; Services; Severities; Source; South Texas; Statistical Data Interpretation; Symptoms; Testing; Tinnitus; Training; Trauma; Veterans; active duty; associated symptom; base; career development; combat; comorbidity; disability; effective intervention; emotional symptom; experience; functional disability; hearing impairment; improved; innovation; neurobiological mechanism; neuroimaging; neuroregulation; novel therapeutics; prospective; protocol development; psychologic; recruit; service member; sleep difficulty; sound; symptom cluster; therapeutically effective; translational scientist; traumatic event; treatment as usual; vigilance

Project Summary Tinnitus and posttraumatic stress disorder (PTSD) are two of the most common service-connected disabilities for active-duty Service Members and Veterans. Tinnitus and PTSD are highly co-morbid, yet distinct disorders. Tinnitus is an auditory disorder in which an illusory auditory percept is experienced, usually as ringing, buzzing, or whooshing sounds, despite no external objective noise source. On the other hand, PTSD is a trauma-related disorder, and is identified by intrusions of the traumatic event, avoidance of reminders, negative alterations in cognition and mood, and hypervigilance or hyperarousal. Similarities between tinnitus and PTSD have been documented among Cambodian refugees, as well as among U.S. Veteran samples. Moreover, the latest neuroimaging data from a recent clinical trial indicated that the auditory-vigilance network was the most dysregulated among active-duty service members with PTSD, compared to combat controls and civilian controls. Due to similar symptoms between tinnitus-related distress and PTSD, and similar dysregulated resting-state brain networks, it remains important to more fully understand how these two distinct disorders may be related. This study will be the first to prospectively examine the overt emotional, behavioral, and cognitive symptoms related to tinnitus-related distress and PTSD, and the overlapping functional connectivity between tinnitus and PTSD. We will examine the overlapping symptoms and neurobiological mechanisms by conducting audiometric and psychological assessments and resting-state functional magnetic resonance imaging (fMRI) among 120 participants (30 with tinnitus and PTSD, 30 with only PTSD, 30 with only tinnitus, and 30 healthy controls). Participants will be recruited from the Frank Tejeda PTSD Clinic and the Audiology Clinic within the South Texas VA Health Care System, and the Hearing Center of Excellence at Lackland Air Force Base. Canonical correlations will be conducted to examine the symptom overlap between tinnitus and PTSD (Aim 1). We aim to neurobiologically characterize tinnitus and PTSD, both separately and conjointly, by conducting fMRI (Aim 2). We also aim to apply modeling to psychometric and neurofunctional data to identify specific regions of the auditory-vigilance network associated with distress related to tinnitus and PTSD. Understanding the shared cognitive, emotional, and behavioral symptoms and neurobiology associated with tinnitus and PTSD will help clinicians and researchers fully understand tinnitus and PTSD independently and conjointly. Results will lead to the identification of neurobiological markers for tinnitus and PTSD, identification of a different phenotype for individuals with both conditions, and development of behavioral and neuro- modulatory therapies that can reduce distress and impairment.

项目摘要 耳鸣和创伤后应激障碍(PTSD)是两种最常见的与服务相关的残疾 适用于现役军人和退伍军人。耳鸣和创伤后应激障碍是高度共病但又截然不同的疾病。 耳鸣是一种听觉障碍，在这种情况下会经历一种幻觉，通常是振铃，嗡嗡声， 或呼呼的声音，尽管没有外部客观噪声源。另一方面，创伤后应激障碍是与创伤相关的 精神障碍，并通过侵入创伤性事件，避免提醒，消极的改变 认知和情绪，以及高度警觉或过度唤醒。耳鸣和创伤后应激障碍的相似之处在于 在柬埔寨难民和美国退伍军人样本中都有记录。此外，最新的 最近的一项临床试验的神经成像数据表明，听觉-警戒网络是最 与战斗控制组和文职人员相比，患有创伤后应激障碍的现役军人中的调节失调 控制。由于耳鸣相关的痛苦和创伤后应激障碍之间的相似症状，以及类似的调节失调 静息状态的大脑网络，更充分地了解这两种截然不同的疾病是如何 可能是有关联的。这项研究将是第一次前瞻性地检查公开的情感、行为和 与耳鸣相关的痛苦和创伤后应激障碍相关的认知症状，以及重叠的功能连接 在耳鸣和创伤后应激障碍之间。我们将通过以下方式检查重叠症状和神经生物学机制 进行听力和心理评估以及静息状态下的功能磁共振 对120名参与者(30名有耳鸣和创伤后应激障碍，30名只有创伤后应激障碍，30名只有耳鸣， 和30名健康对照)。参与者将从Frank Tejeda创伤后应激障碍诊所和听力科招募 南得克萨斯州退伍军人医疗保健系统内的诊所和Lackland Air的卓越听力中心 部队基地。将进行典型相关来检查耳鸣和耳鸣之间的症状重叠。 创伤后应激障碍(目标1)。我们的目标是对耳鸣和创伤后应激障碍分别和联合进行神经生物学特征的研究。 进行功能磁共振成像(AIM 2)。我们还打算将建模应用于心理测量和神经功能数据，以识别 听觉警觉网络的特定区域与与耳鸣和创伤后应激障碍有关的痛苦有关。 了解与以下方面相关的共同认知、情绪和行为症状和神经生物学 耳鸣和创伤后应激障碍将帮助临床医生和研究人员独立和充分地了解耳鸣和创伤后应激障碍 共同的。结果将导致对耳鸣和创伤后应激障碍的神经生物学标志物的鉴定 具有不同表型的个体，以及行为和神经发育- 可以减少痛苦和损伤的调节性治疗。