Video DOT and Economic Incentives to promote adherence to LTBI therapy

视频 DOT 和经济激励措施促进对 LTBI 治疗的依从性

基本信息

  • 批准号:
    10274703
  • 负责人:
  • 金额:
    $ 81.17万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-08 至 2026-06-30
  • 项目状态:
    未结题

项目摘要

Tuberculosis (TB), a highly contagious disease caused by Mycobacterium tuberculosis, remains a major public health concern in the United States. Identifying and treating individuals with latent TB is a key strategy to achieve the goal of TB elimination in the US but there are many challenges to achieving this goal. In Baltimore, where this research will be conducted, more than one-third of non-US-Born individuals have latent TB, and they are disproportionately affected by co-morbidities that increase the risk of progression to active TB, such as diabetes and HIV. However, socioeconomic factors such as poverty, access to care, health literacy, and language or cultural barriers present obstacles to treatment. Treatment for an asymptomatic condition, such as latent TB, is rarely a priority for patients with many other competing needs. The length of treatment (several months for standard “short-course” regimens) is also problematic, particularly for patients experiencing housing or financial instability. Therefore, the majority of individuals infected with latent TB do not complete treatment. We propose to evaluate novel and scalable smartphone enabled interventions to promote completion of treatment for latent TB. Video-directly observed therapy (vDOT) provides multi-faceted adherence support by allowing real-time monitoring of adherence coupled with case-management feedback, is available in patient's preferred languages, and delivers electronic reminders. Likewise, behavior economic (financial) incentives, in which patients receive incentives contingent on ingesting prescribed medications, could mitigate financial stress associated with medical care and lost wages, a common concern among many patients with latent TB infection. Adults with latent TB (N=399) will be randomized to a Usual Care Control, or vDOT, or a vDOT Plus Incentives group. Usual Care Control participants will receive standard care for latent TB. VDOT participants will receive the same Usual Care, but will use smartphones and a commercially available application to receive electronic reminders, submit video-observations to document adherence, and receive case-management real-time feedback. VDOT plus Incentives participants will receive further support through contingent financial incentives (up to $35 per week) for taking prescribed medications under the vDOT system. The primary outcome measure, completion of treatment for latent TB, will be assessed for all participants through MEMS caps (Aim 1). We will also determine the costs, budgetary impact, and incremental cost-effectiveness of the vDOT and vDOT plus incentives interventions (Aim 2). If this intervention is effective in promoting completion of treatment for latent TB and is economically sound, it could prove to be a scalable and effective intervention to promote completion of treatment for latent TB in high-risk populations in Baltimore and in other populations around the world.
结核病(TB)是一种由结核分枝杆菌引起的高度传染性疾病,仍然是公众的主要疾病

项目成果

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MAUNANK SHAH其他文献

MAUNANK SHAH的其他文献

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{{ truncateString('MAUNANK SHAH', 18)}}的其他基金

Clinical Core
临床核心
  • 批准号:
    10431026
  • 财政年份:
    2022
  • 资助金额:
    $ 81.17万
  • 项目类别:
Clinical Core
临床核心
  • 批准号:
    10593166
  • 财政年份:
    2022
  • 资助金额:
    $ 81.17万
  • 项目类别:
Video DOT and Economic Incentives to promote adherence to LTBI therapy
视频 DOT 和经济激励措施促进对 LTBI 治疗的依从性
  • 批准号:
    10447735
  • 财政年份:
    2021
  • 资助金额:
    $ 81.17万
  • 项目类别:
Evaluation of National Video Directly Observed Therapy Implementation
全国视频直视治疗实施情况评价
  • 批准号:
    9556923
  • 财政年份:
    2015
  • 资助金额:
    $ 81.17万
  • 项目类别:
Evaluation of National Video Directly Observed Therapy Implementation
全国视频直视治疗实施情况评价
  • 批准号:
    9756227
  • 财政年份:
    2015
  • 资助金额:
    $ 81.17万
  • 项目类别:
Implementation Science Approaches for Novel TB Diagnostics in HIV Prevalent Areas
在艾滋病毒流行地区实施新型结核病诊断的科学方法
  • 批准号:
    8213622
  • 财政年份:
    2011
  • 资助金额:
    $ 81.17万
  • 项目类别:
Implementation Science Approaches for Novel TB Diagnostics in HIV Prevalent Areas
在艾滋病毒流行地区实施新型结核病诊断的科学方法
  • 批准号:
    8071436
  • 财政年份:
    2011
  • 资助金额:
    $ 81.17万
  • 项目类别:
Implementation Science Approaches for Novel TB Diagnostics in HIV Prevalent Areas
在艾滋病毒流行地区实施新型结核病诊断的科学方法
  • 批准号:
    8610872
  • 财政年份:
    2011
  • 资助金额:
    $ 81.17万
  • 项目类别:
Implementation Science Approaches for Novel TB Diagnostics in HIV Prevalent Areas
在艾滋病毒流行地区实施新型结核病诊断的科学方法
  • 批准号:
    8415935
  • 财政年份:
    2011
  • 资助金额:
    $ 81.17万
  • 项目类别:

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  • 批准号:
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利用技术提高青少年和年轻肾移植或肝移植受者的药物依从性
  • 批准号:
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利用技术提高青少年和年轻肾移植或肝移植受者的药物依从性
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