Development of a low dose clinical lung screening prototype for early detection of COPD and lung cancer using a novel x-ray source to enable Talbot-Lau interferometry
使用新型 X 射线源开发低剂量临床肺部筛查原型,以实现 COPD 和肺癌的早期检测,以实现 Talbot-Lau 干涉测量
基本信息
- 批准号:10274731
- 负责人:
- 金额:$ 84.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-06-01 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AirAlveolarBenignBreast MicrocalcificationCadaverCancerousCause of DeathChestChronic Obstructive Airway DiseaseClinicalCommunitiesDetectionDevelopmentDiagnosisDiagnostic radiologic examinationDiseaseDoseEarly DiagnosisEarly treatmentEnsureEvaluationFamily suidaeGoalsHumanImageInterferometryLegal patentLesionLifeLow Dose RadiationLungLung diseasesMalignant NeoplasmsMalignant neoplasm of lungMass ScreeningMedicalMethodsMorphologyMusPerformancePhasePulmonary PathologyRadiation Dose UnitRecording of previous eventsRoentgen RaysSavingsSignal TransductionSmokingSmoking HistorySolidSourceStructureStructure of parenchyma of lungSystemTechniquesThickThoracic RadiographyTimeTissuesWidthabsorptionbasecontrast imagingdensitydesigndetectoreffective therapyhigh risk populationimaging systemimprovedin vivoinnovationlow dose computed tomographylung imagingmortalitynovelnovel diagnosticsoperationprototypescreeningsuccesssurvival outcometreatment strategytumor
项目摘要
Project Summary/Abstract
Chronic obstructive pulmonary disease (COPD) and lung cancer are the third and sixth most
common causes of death worldwide. One major challenge is that there are no effective screening
methods capable of early detection of these diseases and when these diseases are finally
detected, they are often at advanced stages for which few effective treatment strategies exist. In
the case of lung cancer, more than half of people die within the year of diagnosis.
Darkfield (scattering-based) x-ray contrast has been recently demonstrated to provide exciting
capabilities for early detection of lung pathologies, including cancer and COPD at doses
comparable to conventional chest radiography. This contrast mechanism differs significantly
from current approaches, which use the absorption of x-rays for contrast rather than the
scattering of x-rays. Accessing information provided by this contrast mechanism requires an
emerging grating-based x-ray technique called Talbot-Lau interferometry, which uses three sets
of gratings (source, phase, and detector) to achieve contrast. However, a critical bottleneck for
using this technique at the high x-ray energies (~60 keV) required for imaging through a human
chest is a source grating with the aspect ratios required cannot be fabricated.
We propose to develop a lung darkfield imaging prototype using a major x-ray source innovation
that removes the need for the x-ray source grating to enable Talbot-Lau interferometry at high
x-ray energies. The system will critically enable demonstrations of the clinical potential of
darkfield radiography for early detection of lung pathologies.
The proposed Phase I 6-month project is a proof-of-principle of a grating-less Talbot-Lau
breadboard set-up on a phantom. The proposed Phase II 24-month project is to develop a
complete prototype system and experimentally verify its performance.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David Vine其他文献
David Vine的其他文献
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{{ truncateString('David Vine', 18)}}的其他基金
Development of a low dose clinical lung screening prototype for early detection of COPD and lung cancer using a novel x-ray source to enable Talbot-Lau interferometry
使用新型 X 射线源开发低剂量临床肺部筛查原型,以实现 COPD 和肺癌的早期检测,以实现 Talbot-Lau 干涉测量
- 批准号:
10414995 - 财政年份:2021
- 资助金额:
$ 84.07万 - 项目类别:
Development of a Laboratory Transmission X-ray Microscope for Rapid 3D Cellular Tomography using Zernike Phase Contrast with 2.7 keV
使用 2.7 keV 泽尼克相差技术开发用于快速 3D 细胞断层扫描的实验室透射 X 射线显微镜
- 批准号:
10011500 - 财政年份:2020
- 资助金额:
$ 84.07万 - 项目类别:
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