UW Vision Research Core 3 - Animal Models and Eye Organ Culture

华盛顿大学视觉研究核心 3 - 动物模型和眼器官培养

• 批准号: 10273754
• 负责人: Gillian Jane McLellan
• 金额: $ 17.68万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2023-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10273754
• 关键词: Anesthesia procedures; Animal Experimentation; Animal Model; Animals; Communicable Diseases; Data; Disease; Doctor of Philosophy; Equipment; Evaluation; Experimental Models; Eye; Funding; Glaucoma; Goals; Institution; Organ Culture Techniques; Paper; Pathway interactions; Pattern; Pharmacology and Toxicology; Positioning Attribute; Primates; Qualifying; Research Personnel; Retinal Degeneration; Rodent; United States National Institutes of Health; Vascular Diseases; Vision; Vision research; Visual; Visual system structure; nonhuman primate; retinal imaging; tonometry

CORE 3: ANIMAL MODELS AND EYE ORGAN CULTURE ABSTRACT The goal of the Animal Models and Eye Organ Culture Core is to facilitate the use of animals and eye organ culture to study visual function and visual diseases by qualifying NEI funded researchers. We also assist non- qualifying investigators in generating preliminary data, in support of proposals seeking NIH funding. This is accomplished by providing expertise in complementary animal models across a range of species from rodents to non-human primates (NHPs) and including spontaneous and experimental models of glaucoma, retinal degeneration, ocular vascular disease ocular pharmacology and toxicology and infectious diseases and includes animal handling and anesthesia and, importantly, provision of alternatives to live animal research including eye organ culture. We provide expertise and equipment necessary for the evaluation of visual system structure and function including ERG, multifocal and pattern ERG, VEP, OCT, retinal imaging, tonometry and outflow facility and outflow pathway determination. Because we are one of the only, if not the only, Vision Research Core with an associated regional Primate Center, we are in a unique position to provide access to vision research involving highly translationally relevant NHPs. As a result of this unique expertise, this core has also facilitated vision research by investigators at other institutions and their papers cite this core.

核心3：动物模型和眼器官培养 摘要 动物模型和眼器官文化核心的目标是促进动物和眼器官的使用 通过合格的NEI资助的研究人员来研究视觉功能和视觉疾病的文化。我们还帮助非 使调查人员有资格生成初步数据，以支持寻求NIH资金的提案。这是 通过提供从啮齿动物到一系列物种的互补动物模型的专业知识来实现 对于非人类灵长类动物，包括自发性和实验性的青光眼模型，视网膜 变性、眼血管疾病、眼药理学和毒理学及感染性疾病 包括动物处理和麻醉，更重要的是，提供活体动物研究的替代品 包括眼器官培养。我们提供视觉评估所需的专业知识和设备 系统结构和功能包括ERG，多焦和模式ERG，VEP，OCT，视网膜成像， 眼压测量和流出设备以及流出途径的确定。因为我们是仅有的，如果不是 只有，视觉研究核心与相关的区域灵长类中心，我们处于独特的地位，以提供 获得涉及高度翻译相关的国家卫生政策的视觉研究。由于这一独特的专业知识， 这一核心也促进了其他机构的研究人员的视觉研究，他们的论文引用了这一核心。