Adult epigenetics and telomere length in relation to improved nutrition in early life

成人表观遗传学和端粒长度与改善早期营养有关

基本信息

  • 批准号:
    10562425
  • 负责人:
  • 金额:
    $ 67.34万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-03-15 至 2028-01-31
  • 项目状态:
    未结题

项目摘要

Project Abstract / Summary Our broad goal is to reduce the consequences caused by premature aging through addressing key research gaps that represent challenges to more effective mitigation efforts, particularly in low- and middle-income countries. Our central working hypothesis is that optimal early-life nutrition reduces physiologic aging, specifically via persistent impacts on DNA-related mechanisms (DNA methylation [DNAm], telomere length) over the human life course. The rationale extends key previous findings from the study team, particularly that (1) gestational exposure to the Dutch famine resulted in observable epigenetic differences in adulthood; (2) telomere length of infants and children differ by early-life maternal factors and metabolic indicators; and (3) exposure to a nutrition supplementation intervention led to reduced diabetes incidence at age 37-52 y. We have been following a unique cohort of individuals who participated as children in a nutrition supplementation intervention trial conducted in four villages in Guatemala from 1969 to 1977. We define full intervention exposure as the first 1,000 days of life between conception and two years of age; participants with full exposure will be compared to those with partial (0-999 of these ‘first 1,000 days’) and no intervention exposure. In this study, we propose to extract DNA from frozen buffy coats collected between 2015-2017 from these now-adult cohort participants (n=1,139). We will assay samples for DNAm and leukocyte telomere length, which are two mammalian aging hallmarks. In Aim 1, we will evaluate the impact of nutrition supplementation during the first 1,000 days on DNAm patterns and DNAm- calculated epigenetic age, including PhenoAge and other epigenetic clocks. We will also further examine CpG sites associated with early-life nutrition exposure with Mendelian randomization to assess causal associations with diabetes or BMI. In Aim 2, we will determine whether (1) nutrition supplementation during the first 1,000 days, and (2) life course nutritional status trajectories are associated with longer leukocyte telomere length. This innovative study will be an opportunity to examine the effectiveness of an actionable early-life nutrition intervention on the human health span. It will be the first epigenome-wide association study utilizing Mendelian randomization to assess early-life nutrition supplementation and adult metabolic outcomes to our knowledge. If successful, this study has the potential to identify novel subclinical physiologic aging indices that are nutrition- sensitive, which could lead to better intervention impact assessment and prevention strategies for premature aging. This innovative, multidisciplinary study is optimally suited to answer profound questions relating to early- life determinants of the human health span in adulthood. It builds upon extensive (>50y) and productive (>300 published papers) experience with this cohort, and a successful history of collaboration among experienced and productive researchers at Emory University, the Institute of Central America and Panama, and Vitalant Research Institute.
项目摘要/总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

ARYEH DAVID STEIN其他文献

ARYEH DAVID STEIN的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('ARYEH DAVID STEIN', 18)}}的其他基金

Early childhood nutrition and adult metabolomic and cardiometabolic profiles
幼儿营养和成人代谢组学和心脏代谢特征
  • 批准号:
    9058129
  • 财政年份:
    2014
  • 资助金额:
    $ 67.34万
  • 项目类别:
Early childhood nutrition and adult metabolomic and cardiometabolic profiles
幼儿营养和成人代谢组学和心脏代谢特征
  • 批准号:
    9254217
  • 财政年份:
    2014
  • 资助金额:
    $ 67.34万
  • 项目类别:
Early childhood nutrition and adult metabolomic and cardiometabolic profiles
幼儿营养和成人代谢组学和心脏代谢特征
  • 批准号:
    8630478
  • 财政年份:
    2014
  • 资助金额:
    $ 67.34万
  • 项目类别:
Education and Health Across the Life course in Guatemala
危地马拉终生教育和健康
  • 批准号:
    7007346
  • 财政年份:
    2004
  • 资助金额:
    $ 67.34万
  • 项目类别:
Education and Health Across the Life course in Guatemala
危地马拉终生教育和健康
  • 批准号:
    6736658
  • 财政年份:
    2004
  • 资助金额:
    $ 67.34万
  • 项目类别:
Education and Health Across the Life course in Guatemala
危地马拉终生教育和健康
  • 批准号:
    6849299
  • 财政年份:
    2004
  • 资助金额:
    $ 67.34万
  • 项目类别:
Zinc, Mental Health and School Performance in Mexico
墨西哥的锌、心理健康和学校表现
  • 批准号:
    7233666
  • 财政年份:
    2004
  • 资助金额:
    $ 67.34万
  • 项目类别:

相似海外基金

Development and social implementation of unified developmental screening for health checkups for 3-year-old children in local governments
地方政府统一开展3岁儿童健康检查发育筛查工作的开展及社会实施
  • 批准号:
    23H01039
  • 财政年份:
    2023
  • 资助金额:
    $ 67.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Low vision screening at 3-year-old children's health check-ups: development of a simple and accurate visual acuity testing software
3岁儿童体检中的低视力筛查:开发简单准确的视力测试软件
  • 批准号:
    23K02283
  • 财政年份:
    2023
  • 资助金额:
    $ 67.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
0-3-year-old children's language and literacy learning at home in a digital age (0-3s, Tech and Talk)
数字时代0-3岁儿童在家学习语言和识字(0-3s,Tech and Talk)
  • 批准号:
    ES/W001020/1
  • 财政年份:
    2022
  • 资助金额:
    $ 67.34万
  • 项目类别:
    Research Grant
Associations between physical activity levels of mothers and their 1-3 year old children: examining maternal self-efficacy as a mediator
母亲和 1-3 岁孩子体力活动水平之间的关联:检查作为中介的母亲自我效能感
  • 批准号:
    324339
  • 财政年份:
    2015
  • 资助金额:
    $ 67.34万
  • 项目类别:
Lived time of 3-year-old children in early childhood education and care: Reconsidering continuity of life and development
3岁儿童在幼儿教育和保育中的生存时间:重新思考生命和发展的连续性
  • 批准号:
    15K17356
  • 财政年份:
    2015
  • 资助金额:
    $ 67.34万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Development of family support program to form healthy 3-year-old children and their mothers
制定家庭支持计划,培养健康的3岁儿童及其母亲
  • 批准号:
    24593457
  • 财政年份:
    2012
  • 资助金额:
    $ 67.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
SUPPORTING 2 AND 3 YEAR OLD PRE-KINDERGARTEN READINESS
支持 2 岁和 3 岁儿童做好学前准备
  • 批准号:
    7699693
  • 财政年份:
    2008
  • 资助金额:
    $ 67.34万
  • 项目类别:
ADENOIDECTOMY FOR OTITIS MEDIA IN 2/3 YEAR OLD CHILDREN
2/3 岁儿童中耳炎的腺切除术
  • 批准号:
    6350559
  • 财政年份:
    1997
  • 资助金额:
    $ 67.34万
  • 项目类别:
EMOTIONAL AND BEHAVIOR PROBLEMS IN 1-3 YEAR OLD CHILDREN
1-3 岁儿童的情绪和行为问题
  • 批准号:
    2890762
  • 财政年份:
    1997
  • 资助金额:
    $ 67.34万
  • 项目类别:
EMOTIONAL AND BEHAVIOR PROBLEMS IN 1-3 YEAR OLD CHILDREN
1-3 岁儿童的情绪和行为问题
  • 批准号:
    2841735
  • 财政年份:
    1997
  • 资助金额:
    $ 67.34万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了