Early childhood nutrition and adult metabolomic and cardiometabolic profiles

幼儿营养和成人代谢组学和心脏代谢特征

• 批准号: 8630478
• 负责人: ARYEH DAVID STEIN
• 金额: $ 53.6万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-10 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8630478
• 关键词: Accounting; Acute; Address; Adult; Affect; Age; Attenuated; Biological Assay; Biological Markers; Birth; Blood capillaries; Blood specimen; Build-it; Central America; Characteristics; Child; Child Malnutrition; Childhood; Chronic; Clinical; Cohort Studies; Collaborations; Collection; Communicable Diseases; Communities; Conceptions; Country; Data; Data Analyses; Databases; Development; Diabetes Mellitus; Diagnosis; Dietary Intervention; Disease; Elements; Ensure; Epidemic; Etiology; Event; Exposure to; Failure; Future; Glucose; Growth; Guatemala; Guatemalan; Health; High Prevalence; Human; Income; Infection; Inflammation; Institutes; Intervention; Intervention Trial; Laboratories; Life; Life Cycle Stages; Link; Lipids; Long-Term Effects; Longevity; Malignant Neoplasms; Malnutrition; Methods; Nutritional; Obesity; Panama; Paper; Perinatal; Population Study; Positioning Attribute; Prevalence; Proteins; Publishing; Randomized Controlled Trials; Recording of previous events; Research; Research Personnel; Resolution; Risk; Risk Factors; Role; Sampling; Statistical Methods; Supplementation; Surveys; Testing; Time; Universities; Update; Work; adult nutrition; burden of illness; capillary; cohort; combat; disability-adjusted life years; disorder risk; drinking; early childhood; effective intervention; experience; improved; innovation; member; metabolomics; multidisciplinary; novel; nutrition; public health relevance; research facility; response; socioeconomics

PROJECT SUMMARY / ABSTRACT Nutrition and infection are key determinants of child growth and survival. Chronic inflammation, which results in part from an increased lifetime burden of infectious disease, is an underlying determinant of adult cardiometabolic disease. The modifiability of this risk by improving nutrition in early life is unknown. Our principal objective is to determine whether improvements in early-life nutrition can attenuate the development of cardiometabolic risk. We will collect new data from the INCAP (Guatemala) Nutrition Supplementation Trial cohort. From 1969-77, 2392 children received atole, a high protein and calorie supplement, or fresco, a low calorie drink, for up to 8 y. Children who received atole in the first 3 y of life grew better in childhood and recovered more quickly from diarrheal illness episodes than did children who received fresco. We have followed this cohort prospectively. We propose to re-contact the surviving members of the cohort. The cohort will be 38-53 y old, an ideal age to assess cardiometabolic risk. We will conduct clinical examinations, including (for the first time in this cohort) collection of biomarkers of cardiometabolic risk. We will assay the samples for established and novel biomarkers, including highly innovative metabolomic profiling. We will update and enhance the extensive life-course data that we collected in previous surveys. We will link the new data to our existing rich database to address critical questions regarding the long-term effects on cardiometabolic health of both chronic under-nutrition and an effective intervention to combat under-nutrition, in the context of a community-randomized trial that controls for otherwise intractable questions of endogeneity. The study will be unique in its ability to address unanswered questions relating to early life determinants of adult health. This prospectively-studied cohort has reached an age where the prevalence of cardiometabolic risk is non-negligible. The highly productive research team has extensive experience with survey work among this cohort, demonstrated capacity to link data across study waves, and extensive experience with the appropriate field methods, laboratory methods, and statistical approaches to data analysis. The resulting extensive repository of data and samples will enhance the value of the cohort for future research. Taken together, these elements ensure that the study will be well positioned to successfully address critical understudied questions in human health and development.

项目总结/摘要 营养和感染是儿童生长和存活的关键决定因素。慢性炎症， 部分原因是终生感染性疾病的负担增加， 成人心脏代谢疾病的决定因素。通过改善营养可以改变这种风险 早期的生活是未知的。 我们的主要目标是确定早期营养的改善是否会减弱 心脏代谢风险的发展。我们将从INCAP（危地马拉）收集新数据 营养补充试验队列。从1969年至1977年，2392名儿童获得了阿托莱， 蛋白质和热量补充剂，或fresco，一种低热量饮料，最多8年。的儿童 在生命的前3年接受了atole，在童年时期生长得更好， 比那些接受壁画的孩子更容易生病。我们跟踪了这群人 前瞻性地。我们建议重新联系幸存者。则将队列 38-53岁是评估心脏代谢风险的理想年龄。我们将进行临床检查， 包括（在该队列中首次）收集心脏代谢风险的生物标志物。我们将 分析样品中已建立的和新的生物标志物，包括高度创新的 代谢组学分析我们将更新和增强我们所掌握的广泛的生命过程数据， 在以前的调查中收集。我们将把新的数据链接到我们现有的丰富的数据库， 关于长期影响心脏代谢健康的关键问题， 营养不良和有效干预，以消除营养不良， 社区随机试验，控制其他棘手的内分泌问题。 这项研究将是独一无二的，它能够解决与早期生活有关的悬而未决的问题。 成人健康的决定因素。这个前瞻性研究的队列已经到了一个年龄， 心脏代谢风险的普遍性不可忽略。高效率的研究团队 在这一群体中具有广泛的调查工作经验，证明有能力将数据联系起来 跨研究波，并在适当的现场方法，实验室 方法和数据分析的统计方法。由此产生的大量数据存储库 和样本将提高队列的价值，为未来的研究。综上所述各项 这些因素确保研究能够成功地解决关键问题， 对人类健康和发展的研究不足。