Early childhood nutrition and adult metabolomic and cardiometabolic profiles

项目摘要/摘要 营养和感染是儿童生长和存活的关键决定因素。慢性炎症， 这在一定程度上是由于终身传染病负担的增加，是一种潜在的 成人心脏代谢性疾病的决定因素。通过改善营养来改变这种风险 在早期的生命是未知的。 我们的主要目标是确定早期营养的改善是否会减弱 心脏代谢风险的发展。我们将从INCAP(危地马拉)收集新的数据 营养补充剂试验队列。从1969-77年间，2392名儿童获得了ATOLE，这是最高的 蛋白质和卡路里补充剂，或Fresco，一种低卡路里饮料，适用于8岁以下的儿童 在生命的前3年接受燕麦片，在童年时期生长得更好，恢复得更快 服用FRESCO的儿童发生腹泻疾病的次数比服用FRESCO的儿童要少。我们一直在跟踪这群人 未雨绸缪。我们建议重新联系队列中幸存的成员。这批人将是 38-53岁，是评估心脏代谢风险的理想年龄。我们将进行临床检查， 包括(在这个队列中第一次)收集心脏代谢风险的生物标志物。我们会 检测样品中已建立的和新的生物标记物，包括高度创新的 代谢组学研究。我们将更新和增强广泛的生命历程数据，我们 在以前的调查中收集的数据。我们将把新数据链接到我们现有的丰富数据库，以解决 关于慢性和慢性心脏病对心脏代谢健康的长期影响的关键问题 营养不良和有效干预以消除营养不良，在 社区随机试验，对照其他难以解决的内生性问题。 这项研究的独特之处在于它能够解决与早期生活有关的悬而未决的问题 成人健康的决定因素。这一前瞻性研究的队列已经达到了一个年龄， 心脏代谢风险的流行是不容忽视的。高生产率的研究团队拥有 在这一群体中的调查工作方面有丰富的经验，证明有能力将数据联系起来 跨越研究浪潮，并在适当的现场方法、实验室方面拥有丰富的经验 方法，以及数据分析的统计方法。由此产生的大量数据存储库 样本将提高队列的价值，用于未来的研究。这些加在一起， 要素确保研究将处于有利地位，以成功解决关键问题 对人类健康和发展方面的问题研究不足。

PROJECT SUMMARY / ABSTRACT Nutrition and infection are key determinants of child growth and survival. Chronic inflammation, which results in part from an increased lifetime burden of infectious disease, is an underlying determinant of adult cardiometabolic disease. The modifiability of this risk by improving nutrition in early life is unknown. Our principal objective is to determine whether improvements in early-life nutrition can attenuate the development of cardiometabolic risk. We will collect new data from the INCAP (Guatemala) Nutrition Supplementation Trial cohort. From 1969-77, 2392 children received atole, a high protein and calorie supplement, or fresco, a low calorie drink, for up to 8 y. Children who received atole in the first 3 y of life grew better in childhood and recovered more quickly from diarrheal illness episodes than did children who received fresco. We have followed this cohort prospectively. We propose to re-contact the surviving members of the cohort. The cohort will be 38-53 y old, an ideal age to assess cardiometabolic risk. We will conduct clinical examinations, including (for the first time in this cohort) collection of biomarkers of cardiometabolic risk. We will assay the samples for established and novel biomarkers, including highly innovative metabolomic profiling. We will update and enhance the extensive life-course data that we collected in previous surveys. We will link the new data to our existing rich database to address critical questions regarding the long-term effects on cardiometabolic health of both chronic under-nutrition and an effective intervention to combat under-nutrition, in the context of a community-randomized trial that controls for otherwise intractable questions of endogeneity. The study will be unique in its ability to address unanswered questions relating to early life determinants of adult health. This prospectively-studied cohort has reached an age where the prevalence of cardiometabolic risk is non-negligible. The highly productive research team has extensive experience with survey work among this cohort, demonstrated capacity to link data across study waves, and extensive experience with the appropriate field methods, laboratory methods, and statistical approaches to data analysis. The resulting extensive repository of data and samples will enhance the value of the cohort for future research. Taken together, these elements ensure that the study will be well positioned to successfully address critical understudied questions in human health and development.