StuDy AimED at Increasing AlCohol AbsTinEnce (DEDICATE)

旨在提高酒精戒断率的研究（奉献）

• 批准号: 10577022
• 负责人: Hagar Hallihan
• 金额: $ 18.6万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10577022
• 关键词: Advanced Development; Affect; African American; Aftercare; Age; Alcohol consumption; Alcohol dependence; Alcohols; Amygdaloid structure; Award; Behavior Therapy; Benchmarking; Brain region; Brief Psychotherapy; Chronic Disease; Client satisfaction; Clinical Research; Collaborations; Competence; Complement; Data; Data Analyses; Data Collection; Disease; Elderly; Enrollment; Ensure; Environment; Evaluation; Evidence based treatment; Female; Focus Groups; Functional Magnetic Resonance Imaging; Future; Goals; Health; Impairment; Individual; Institution; Intervention; Intervention Trial; Interview; Knowledge; Leadership; Life; Mediating; Mentors; Mentorship; National Institute on Alcohol Abuse and Alcoholism; Neurobiology; Neurosciences; Outcome; Participant; Persons; Phase; Positioning Attribute; Prefrontal Cortex; Prevention; Protocols documentation; Public Health; Qualitative Research; Questionnaires; Randomized; Randomized, Controlled Trials; Recommendation; Research; Research Methodology; Research Personnel; Research Training; Rewards; Science; Senior Scientist; Smoking; Structure; Symptoms; System; Target Populations; Testing; Therapeutic Intervention; Training; Treatment Efficacy; Urine; Ventral Striatum; Woman; acceptability and feasibility; age group; aged; alcohol abstinence; alcohol abuse therapy; alcohol screening; alcohol use disorder; arm; behavioral clinical trial; behavioral study; brain dysfunction; clinically relevant; cognitive control; contingency management; cost; design; effective therapy; effectiveness evaluation; efficacy evaluation; efficacy testing; experience; feasibility testing; follow-up; functional MRI scan; high risk drinking; improved; innovation; male; meetings; motivational enhancement therapy; negative affect; neural; neural circuit; neuroimaging; neuromechanism; patient population; pilot trial; primary outcome; problem solving therapy; programs; randomized, clinical trials; reduced alcohol use; remote delivery; reward circuitry; satisfaction; skills; therapy design; therapy development; treatment effect; videoconference; young adult

PROJECT SUMMARY/ABSTRACT The long-term objective of this award is to support Dr. Hagar Hallihan, an African American woman, in advanced training in clinical research and neuroscience and establishing an independent research program. Her research program focuses on developing clinically relevant and effective integrated behavioral interventions to improve treatment efficacy and better understand the neuro mechanism of treatment for young adults with alcohol use disorder (AUD). Her mentorship team is a transdisciplinary group of senior scientists with research expertise in behavioral clinical trials, behavioral intervention development, AUD in young adults, neuroimaging data, and quantitative and qualitative research methods. She will continue working with her current T32 mentor, Dr. Ma, a senior scientist with extensive experience mentoring trainees. This will be complemented by content and mentoring expertise from Drs. Ajilore, Rospenda, and Wu. Collectively, this team will provide an outstanding training environment that will allow Dr. Hallihan to fill critical gaps in her knowledge and skill set relating to the study of behavior interventions and neural mechanisms underlying treatment for young adults with AUD. Her training goals are to develop skills in (1) designing and assessing effectiveness of mechanistic randomized clinical trials, (2) competency in statistical and fMRI data analyses, and (3) knowledge and skills in the neurobiology of alcohol addiction. In addition, she will develop professional skills in scientific leadership and interdisciplinary team science. Achieving these goals will strengthen her scholarly activities, establish important collaborations, and acquire critical data that will ensure her successful transition to independence. The proposed research plan builds on Dr. Hallihan’s prior research training in AUD among young adults. AUD, a chronic disease of impaired ability to stop or control alcohol use, is a costly major public health problem, most prevalent in young adults (aged18-24 yr). Heavy alcohol consumption impairs brain structure and function, more severely in young adults than in older adults. However, evidence-based treatments for AUD in young adults are lacking, and the neural mechanisms following available behavior treatments are poorly understood. The aims of the K99 phase are (1) to develop an integrated contingency management (CM) and Problem-Solving Therapy (PST), CM-PST intervention to improve alcohol abstinence among young adults with AUD, and (2) test feasibility and acceptability of the intervention. The aims of the R00 phase are to (1) test the efficacy of CM-PST vs CM alone in a 2-arm pilot RCT, and (2) assess neural mechanisms associated with CM-PST treatment effects in young adults with AUD. Support from this award will enable Dr. Hallihan to launch an independent program of research that contributes to the field by 1) developing and implementing an innovative intervention to improve alcohol abstinence among young adults with AUD, and 2) assess neural mechanisms of successful treatment among young adults with AUD to inform future intervention and prevention efforts and ultimately reduce the public health burden of AUD.

项目摘要/摘要 该奖项的长期目标是支持非裔美国妇女Hagar Hallihan博士， 在临床研究和神经科学方面的高级培训，并建立独立的研究计划。 她的研究计划侧重于开发临床相关和有效的综合行为 干预措施，以提高治疗效果，更好地了解治疗年轻人的神经机制 酒精使用障碍（AUD）她的导师团队是一个由资深科学家组成的跨学科小组 在行为临床试验、行为干预开发、年轻人的AUD方面具有研究专长， 神经影像学数据，定量和定性研究方法。她将继续与她合作。 现任T32导师马博士是一位资深科学家，拥有丰富的学员指导经验。这将是 由Ajilore博士、Rospenda博士和Wu博士的内容和指导专业知识补充。总的来说，这 团队将提供一个出色的培训环境，使哈利汉博士能够填补她的关键空白， 与行为干预和神经机制研究相关的知识和技能 青少年AUD治疗她的培训目标是培养以下技能：（1）设计和评估 机械随机临床试验的有效性，（2）统计和fMRI数据分析的能力， （3）酒精成瘾的神经生物学知识和技能。此外，她还将发展专业 科学领导和跨学科团队科学的技能。实现这些目标将使她更加坚强 学术活动，建立重要的合作，并获得关键数据，将确保她的成功 过渡到独立。拟议的研究计划建立在Hallihan博士先前在AUD的研究培训基础上 在年轻人中。AUD是一种阻止或控制酒精使用能力受损的慢性疾病， 公共卫生问题，在年轻人（18 -24岁）中最为普遍。大量饮酒会损害 大脑结构和功能，年轻人比老年人更严重。然而，基于证据的 缺乏对年轻人AUD的治疗，并且可用行为的神经机制 治疗方法知之甚少。K99阶段的目标是：（1）制定综合应急计划 管理（CM）和解决问题疗法（PST），CM-PST干预，以改善戒酒 在患有AUD的年轻成年人中，和（2）测试干预的可行性和可接受性。R 00的目标 阶段是（1）在2组试点RCT中测试CM-PST与单独CM相比的疗效，以及（2）评估神经系统疾病的发生率。 与CM-PST治疗对AUD年轻成人的作用相关的机制。该奖项的支持将 使哈利汉博士能够启动一项独立的研究计划，通过以下方式为该领域做出贡献：1）开发 实施创新干预措施，改善患有AUD的年轻人的戒酒情况， 2)评估年轻成人AUD患者成功治疗的神经机制，为未来提供信息 干预和预防工作，并最终减少AUD的公共卫生负担。