Core A: Mouse Core

核心A：鼠标核心

• 批准号: 10576378
• 负责人: Mark S Anderson
• 金额: $ 24.11万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-17 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10576378
• 关键词: Animal Husbandry; Animals; Autoimmune; Autoimmune Diseases; Autoimmunity; Biological Process; Breeding; Caring; Complex; Diabetes Mellitus; Diabetic mouse; Ensure; Environment; Generations; Genetic; Housing; Immune Tolerance; Immune system; Immunologic Deficiency Syndromes; Inbred NOD Mice; Incidence; Insulin-Dependent Diabetes Mellitus; Knock-out; Maintenance; Modeling; Mouse Strains; Mus; Reporter; Research; Research Personnel; STAT3 gene; Transgenic Organisms; Variant; animal facility; experience; gain of function; genetic makeup; genetic strain; improved; member; novel; pathogen; programs; tool

STAT3 Variants as a Rheostat of Immune Tolerance Mouse Core Project Summary The use of genetically altered mice has revolutionized the study of complex biological processes, including immune tolerance and autoimmunity. All the projects in this P01 rely heavily on the use of genetically modified transgenic, knockout, and autoimmune-prone mouse strains. Many autoimmune prone and immunodeficient lines require specific expertise and conditions for optimal research, including housing in pathogen-free environments. Additionally, breeding and care of such animals can become complex when dealing with multiple genetically modified lines and different genetic strains of mice. A mouse Core is envisioned that will help streamline and improve efficiencies with the generation and maintenance of genetically complex lines in a healthy, pathogen-free environment. Because of the reliance of several P01 projects on the NOD mouse model of diabetes and the novel STAT3 gain of function (GOF) mouse lines, much of the Core efforts will revolve around the maintenance, distribution and use of these lines in combination with other relevant immune system reporters or immunodeficient lines. In this way, the Core can help ensure the quality, genetic lineage, and sharing of animals needed for the collaborative studies of the P01 investigators.

STAT3变异作为免疫耐受小鼠核心的变阻器