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中文摘要
翻译
作为免疫耐受管理核心的STAT3变异体 项目摘要 强大的项目协作(P01)需要关键的集中式组织结构来促进实验室到实验室 互动。行政核心将提供有效完成以下工作所需的基础设施 综合项目目标。正如研究计划所详述,拟议的三个项目均有 代表两个不同机构的调查人员的贡献。一个强大的行政中心, 以行政核心为代表的是P01的重要组成部分,以使这种机构间方法 成功。此管理核心服务于简化从管理视频会议到面对面的一切- 面对面的会议,以协调法规要求和共享研究的实际考虑 样本。通过支持预定的定期会议,核心将确保高效的数据传输 以及项目进展的最新情况。个别研究人员计划的贡献能否成功,可能取决于 根据另一名调查员产生的结果或样本。核心将发挥作用,以确保信息 并以一种有效的方式移交标本,以不耽误计划的时间表。
英文摘要
STAT3 Variants as a Rheostat of Immune Tolerance Administrative Core Project Summary A strong Project (P01) collaboration requires key centralized organizational structures to foster lab-to-lab interactions. The Administrative Core will provide the infrastructure required for efficient completion of the combined project goals. As detailed in the Research Plan, each of the three proposed projects has contributions from investigators representing two separate institutions. A strong administrative hub, represented by the Administrative Core, is an essential part of the P01 to make this inter-institutional approach successful. This Administrative Core serves to faciliate everything from managing videoconferencing and face- to-face meetings to coordinating regulatory requirements and practical considerations for sharing of research samples. By supporting scheduled recurring meetings, the core will function to ensure efficient data transfer and updates on project progress. The success of an individual investigator's planned contributions may hinge on the results or samples generated from another investigator. The core will function to ensure that information and specimens are transferred in an efficient manner as to not delay the planned timelines.
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Project 2: STAT3 as a trigger for T1D
STAT3 variants as a rheostat of immune tolerance
Tuning peptide specifities for T cell tolerance in Type 1 diabetes
Alterations of leukocyte integrin signaling leading to diabetes and autoimmunity
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