Modern approach to electrical conductivity mapping of spinal cord tissues

脊髓组织电导率测绘的现代方法

• 批准号: 10576868
• 负责人: Matthieu Kevin Chardon
• 金额: $ 20.11万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10576868
• 关键词: 3-Dimensional; Anisotropy; Behavior; Calibration; Cells; Cerebral cortex; Chest; Communities; Data; Data Set; Dependence; Electric Conductivity; Electric Stimulation; Electrodes; Electromagnetics; Electronics; Electrophysiology (science); Felis catus; Frequencies; Future; Gel; Hospitals; Human; Image; Implant; Knowledge; Left; Length; Location; Measurement; Measures; Modeling; Modernization; Needles; Neurostimulation procedures of spinal cord tissue; Pain management; Pathway interactions; Patients; Property; Research; Research Personnel; Resistance; Safety; Sampling; Signal Transduction; Source; Spinal; Spinal Cord; System; Tissues; Tungsten; Vertebral column; cell type; density; design; dorsal column; electric impedance; electrical property; experimental study; improved; neural; neuroregulation; novel; spinal cord mapping; targeted treatment; white matter

Project Summary Over 30,000 patients per year receive electrical stimulation of the spinal cord (neuromodulation) as a means of pain management. However, optimizing the delivery parameters is difficult, partly because of an extremely valuable but incomplete dataset on the electrical conductivity of spinal cord tissues. We traced the lineage of the spinal tissue electrical conductivity sources of the majority of modern electrostimulation models to a single source, Ranck 1965. The experiments within Ranck 1965 only provided two types of data: (1) bulk spinal tissue conductivity at 5, 50, 500, and 5k Hz; and (2) small volume (8 mm3) of dorsal column tissue conductivity at 5-10 Hz. Since the distribution of spinal cord cells throughout the cord is not uniform, the bulk spinal tissue conductivity sweep does not provide enough spatial information for a detailed electrical model between different sections, layers, and tissue types of the spinal cord. Our project seeks to significantly improve on Ranck 1965 by obtaining 10-1M Hz, large-volume (40 cm3), and multi-directional conductivity data for electromagnetic modeling of neuromodulation using an electronically-controlled conductivity probe array. With our findings, neuroscientists and neuromodulation researchers and designers will be able to provide more targeted therapies as a result of a more-detailed and rigorous electromagnetic spinal cord model.

项目摘要 每年有超过30，000名患者接受脊髓电刺激（神经调节），作为一种手段， 疼痛管理然而，优化输送参数是困难的，部分原因是由于极端的 脊髓组织电导率的有价值但不完整的数据集。我们追踪了 大多数现代电刺激模型的脊髓组织电导率源 来源， Ranck 1965. Ranck 1965年的实验只提供了两种类型的数据：（1）大块脊柱组织 在5、50、500和5 k Hz下的电导率;以及（2）在5-10 Hz下的小体积（8 mm 3）背柱组织电导率 Hz.由于脊髓细胞在整个脊髓中的分布是不均匀的， 电导率扫描不提供足够的空间信息，用于不同电导率之间的详细电模型。 脊髓的切片、层次和组织类型。我们的项目旨在显著改善Ranck 1965 通过获得10- 1 M Hz、大体积（40 cm 3）和多方向的电磁传导率数据， 使用电子控制的电导率探针阵列对神经调节进行建模。根据我们的发现， 神经科学家和神经调节研究人员和设计人员将能够提供更多的靶向治疗 这是一个更详细和严格的电磁脊髓模型的结果。