Pediatric Cardiovascular and Pulmonary Research Training Program

儿科心血管和肺研究培训计划

基本信息

批准号：
10576362
负责人：
Juliane Bubeck Wardenburg
金额：
$ 35.29万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10576362
关键词：
Cardiovascular system Childhood Lung Research Training Training Programs

项目摘要

PROJECT SUMMARY/ABSTRACT This is a renewal application for a high successful program designed to attract and train both predoctoral and postdoctoral investigators in basic investigation of childhood diseases related to cardiovascular and pulmonary biology. The need for a training program in the cellular and molecular basis of cardiovascular and pulmonary disease, especially of physician scientists interested in childhood diseases, is based upon clear evidence of a declining national pool of such individuals at both the faculty and trainee levels. Currently, few pediatric cardiology or pulmonary fellowship programs in American medical centers provide adequate training in this area of research, either at the bench or in structured clinical investigation. Our program is designed to address this need from two important perspectives: 1) To allow pediatric and other clinical fellows with an interest in basic research to develop research competence and career training; 2) To attract and train talented basic scientists at the pre- and post-doctoral levels to study mechanisms related to cardiorespiratory disease in childhood. Our program has been shaped by feedback from reviewers of the previous program, by advice from our faculty and program advisors, by past trainees, and by the inclusion of new faculty and core programs at Washington University that allow us to expand the training experience of our trainees. In addition to continuing our strong training in developmental/cell biology and the molecular basis of disease, the proposed program will take advantage of institutional strengths in genetics, stem cell biology, genomics, and bioinformatics—all of which are components of the foundation of modern research. In addition, we have a newly incorporated focus on infection of the cardiorespiratory system, a leading cause of pediatric morbidity and mortality worldwide. We have maintained a training curriculum for 4 postdoctoral and 2 predoctoral fellows with an uninterrupted 2-3 year block of full-time investigation. This focus is enhanced by a multidisciplinary core of didactic seminars, journal clubs and formal coursework that are designed for each trainee through consultation with the mentor/program administrators to provide individualized education in key aspects of cardiopulmonary development and disease. Our objectives are: 1) to provide extensive mentoring to the trainee for career development and for developing independent research plans that focus on pediatric diseases; 2) to promote training in basic cell and molecular biology, genomics, and bioinformatics together with clinical translational research; and 3) to guide our trainees’ development so that, after the completion of training, successful competition for independent funding is likely.

项目摘要/摘要这是一个续签申请，用于一项旨在吸引和培训前术和培训的高成功计划与心血管和肺部有关的儿童疾病基本调查的博士后研究者生物学。需要在心血管和肺部的细胞和分子基础上进行训练程序疾病，特别是对儿童疾病感兴趣的身体科学家的疾病，是基于明确的证据在教职员工和学员级别下，这些人的民族池降低了。目前，小儿很少美国医疗中心的心脏病学或肺奖学金计划在此提供了足够的培训研究领域，无论是在板凳上还是结构化临床研究。我们的计划旨在解决从两个重要的角度来看，这种需求：1）允许儿科和其他临床研究员有兴趣发展研究能力和职业培训的基础研究； 2）吸引和训练受过基础博士前后的科学家研究与心肺疾病有关的机制童年。我们的计划是由上一个计划的审稿人的反馈来塑造的，我们的教职员工和计划顾问，过去的学员，以及包括新的教师和核心计划华盛顿大学，使我们能够扩大学员的培训经验。除了继续我们在发育/细胞生物学和疾病的分子基础方面进行的深入培训，拟议的计划将利用遗传学，干细胞生物学，基因组学和生物信息学方面的制度优势 - 这是现代研究基础的组成部分。此外，我们有一个新的重点关于心肺系统的感染，这是全球小儿发病率和死亡率的主要原因。我们维持了4个博士后和2个培训课程，而2-3的培训课程全日制投资年度。教义半座的多学科核心增强了这种重点，期刊俱乐部和正式课程是为每个学员设计的，通过咨询导师/计划管理人员在心肺的关键方面提供个性化教育发展与疾病。我们的目标是：1）为学员提供广泛的心理开发和制定关注小儿疾病的独立研究计划； 2）促进基本细胞和分子生物学，基因组学和生物信息学的培训以及临床翻译研究; 3）指导我们培训的发展，以便在完成培训后成功可能会争取独立资金。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

An iPS-derived in vitro model of human atrial conduction.

DOI：
10.14814/phy2.15407
发表时间：
2022-09
期刊：
Physiological reports
影响因子：
2.5
作者：
通讯作者：

NADPH Oxidase Limits Collaborative Pattern-Recognition Receptor Signaling to Regulate Neutrophil Cytokine Production in Response to Fungal Pathogen-Associated Molecular Patterns.

DOI：
10.4049/jimmunol.2001298
发表时间：
2021-08-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
0
作者：
Yoo DG;Paracatu LC;Xu E;Lin X;Dinauer MC
通讯作者：
Dinauer MC

Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection.

DOI：
10.1016/j.jacbts.2022.09.001
发表时间：
2023-03
期刊：
JACC-BASIC TO TRANSLATIONAL SCIENCE
影响因子：
9.7
作者：
Brumback, Brittany D.;Dmytrenko, Oleksandr;Robinson, Ashley N.;Bailey, Adam L.;Ma, Pan;Liu, Jing;Hicks, Stephanie C.;Ng, Sherwin;Li, Gang;Zhang, David M.;Lipovsky, Catherine E.;Lin, Chieh-Yu;Diamond, Michael S.;Lavine, Kory J.;Rentschler, Stacey L.
通讯作者：
Rentschler, Stacey L.

Multiscale biophysical models of cardiomyopathies reveal complexities challenging existing dogmas.

心肌病的多尺度生物物理模型揭示了挑战现有教条的复杂性。