Cancer Genomics Shared Resource

癌症基因组学共享资源

• 批准号: 10576821
• 负责人: Kenneth B Beckman
• 金额: $ 101.89万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10576821
• 关键词: Address; Advanced Malignant Neoplasm; Attention; Awareness; Basic Science; Behavior; Bioinformatics; Biological Assay; Cancer Center; Cancer Center Support Grant; Cancer Research Project; Cells; Collaborations; Communities; Complex; Consultations; Cytogenetics; Data; Data Analyses; Detection; Development; Differential Diagnosis; Doctor of Philosophy; Drug resistance; Education; Ensure; Equipment; Etiology; Funding; Gene Fusion; Generations; Genomics; Genomics Shared Resource; Hematologic Neoplasms; Laboratories; Link; Liquid substance; Malignant Neoplasms; Methods; Minnesota; Mission; Molecular; Names; Neoplasm Metastasis; Pathway interactions; Prognosis; Quality Control; Recurrent disease; Research; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Resources; Sampling; Science; Scientist; Selection for Treatments; Services; Solid Neoplasm; Structure; Techniques; Technology; Testing; Time; Tissues; Training; Translational Research; Universities; Work; cancer genomics; clinical care; cost; feasibility testing; genomic tools; instrumentation; member; next generation sequencing; novel; skills; symposium; synergism; targeted sequencing; targeted treatment; tumorigenesis

Cancer Genomics Shared Resource Summary The mission of the Cancer Genomics Shared Resource (CGSR) is to provide Masonic Cancer Center (MCC) investigators with broad, deep, and affordable access to state-of-the-art genomic services. In addition to maintaining a world-class suite of genomic instrumentation, the Directors and staff of the CGSR help advance investigators' science through consultation about technology choices and workflows, including upstream preparative and downstream bioinformatics and data interpretation steps. The skilled staff can perform all of the technical components of the work or can collaborate with the investigator's own laboratory staff, providing training and access to equipment they would otherwise not be able to utilize. CGSR assays range from conventional cytogenetics to the most current single-cell and next-generation sequencing technologies. These enable MCC researchers to address critical questions relevant to the etiology, behavior, and treatment of hematologic and solid tumors. There is no other resource at the University of Minnesota that provides these services to researchers. The structure and name of this Shared Resource was changed during the last funding cycle. Specifically, the Cytogenomics Shared Resource merged with the services of the University of Minnesota Genomics Center (UMGC) to become the CGSR. The CGSR, co-directed by Drs. Betsy Hirsch and Kenneth Beckman, with expertise in cytogenomics and molecular genomic technologies, respectively, will simplify navigation by MCC members through the complex spectrum of genomic assays offered at the UMN. The CGSR will ensure focused attention on the specific scientific needs of MCC investigators while benefitting from the synergies resulting from integration with the UMGC which serves the entire University community. In the new CGSR, there will be an additional PhD-level full-time equivalent (FTE) Research Scientist devoted specifically to customized work for MCC members, facilitating the development of novel assays, generation of pilot data, and the advancement of cancer research projects.

癌症基因组学共享资源摘要 癌症基因组学共享资源（CGSR）的使命是为共济会癌症中心（MCC）提供 研究人员广泛，深入，负担得起的访问国家的最先进的基因组服务。除了 保持世界一流的基因组仪器套件，CGSR的董事和工作人员帮助推进 调查人员通过就技术选择和工作流程进行协商， 制备和下游生物信息学和数据解释步骤。熟练的工作人员可以执行所有 工作的技术组成部分，或者可以与研究者自己的实验室工作人员合作， 培训和获得他们原本无法使用的设备。CGSR检测范围从 从传统的细胞遗传学到最新的单细胞和下一代测序技术。这些 使MCC研究人员能够解决与病因学，行为和治疗相关的关键问题， 血液和实体肿瘤。明尼苏达大学没有其他资源提供这些 为研究人员服务。 在上一个供资周期，这一共享资源的结构和名称发生了变化。具体而言是 细胞基因组学共享资源与明尼苏达大学基因组学中心的服务合并 （UMGC）成为CGSR。CGSR由Betsy Hirsch博士和Kenneth Beckman博士共同指导， 分别在细胞基因组学和分子基因组学技术方面的专业知识将简化MCC的导航 通过UMN提供的复杂的基因组检测谱，CGSR将确保 重点关注MCC研究人员的具体科学需求，同时受益于协同作用， 与为整个大学社区提供服务的UMGC整合而成。在新的CGSR中， 将有一个额外的博士水平的全职等效（FTE）研究科学家专门致力于 为MCC成员定制工作，促进新检测方法的开发，产生试验数据，以及 癌症研究项目的进展。