Fusion inhibitors that block host-to-host transmission of SARS-CoV-2

阻止 SARS-CoV-2 宿主间传播的融合抑制剂

基本信息

  • 批准号:
    10237600
  • 负责人:
  • 金额:
    $ 75.02万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-08-01 至 2026-07-31
  • 项目状态:
    未结题

项目摘要

Coronaviruses (CoVs) can cause life-threatening diseases. The recently emerging coronavirus-related illness was named coronavirus disease 2019 (abbreviated “COVID-19”) by the World Health Organization. COVID-19 is caused by SARS-CoV-2. Like its predecessors SARS-CoV and MERS-CoV, SARS-CoV-2 (S-CoV-2) is a betacoronavirus that is thought to have originated in bats. Originally its spread was animal-to-human, but human-to-human transmission is now widespread. No vaccines and treatments for COVID-19 are available, and these are urgently needed to address the outbreak as well as inevitable ongoing infection. Antivirals that target viral entry into the host cell have been proven effective against a wide range of viruses. In this proposal, we will apply the results of our fundamental research to the development of novel peptide inhibitors of SARS- CoV-2 entry. We have designed lipid-conjugated fusion-inhibitory peptides that efficiently inhibit coronavirus infection in in vitro, ex vivo, and in vivo. We propose to synthesize and evaluate novel lipidated peptides that have enhanced efficacy. These inhibitors will be evaluated for antiviral activity against live SARS-CoV-2 virus. Promising candidates will be tested in transmission experiments in a ferret model. This application will determine whether our approach to entry inhibition of SARS-CoV-2 prevents infection in vivo. 1. To optimize antiviral potency of HRC-lipopeptide fusion inhibitors. 2. To pre-clinically evaluate HRC-lipopeptide fusion inhibitors biodistribution, toxicity and protection against SARS-CoV-2 infection or transmission in vivo.
冠状病毒可导致危及生命的疾病。最近新出现的冠状病毒相关疾病

项目成果

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Matteo Porotto其他文献

Matteo Porotto的其他文献

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{{ truncateString('Matteo Porotto', 18)}}的其他基金

Design of fusion inhibitors to block measles host-to-host infection
设计融合抑制剂来阻止麻疹宿主间感染
  • 批准号:
    10753711
  • 财政年份:
    2023
  • 资助金额:
    $ 75.02万
  • 项目类别:
Design of fusion inhibitors to block measles host-to-host infection
设计融合抑制剂来阻止麻疹宿主间感染
  • 批准号:
    10457081
  • 财政年份:
    2021
  • 资助金额:
    $ 75.02万
  • 项目类别:
Fusion inhibitors that block host-to-host transmission of SARS-CoV-2
阻止 SARS-CoV-2 宿主间传播的融合抑制剂
  • 批准号:
    10457959
  • 财政年份:
    2021
  • 资助金额:
    $ 75.02万
  • 项目类别:
Fusion inhibitors that block host-to-host transmission of SARS-CoV-2
阻止 SARS-CoV-2 宿主间传播的融合抑制剂
  • 批准号:
    10668973
  • 财政年份:
    2021
  • 资助金额:
    $ 75.02万
  • 项目类别:
Small molecules to block measles spreading in the central nervous system
小分子阻止麻疹在中枢神经系统中传播
  • 批准号:
    9986209
  • 财政年份:
    2019
  • 资助金额:
    $ 75.02万
  • 项目类别:
Development of therapeutic fusion inhibitor peptides for Measles encephalitis
开发治疗麻疹脑炎的融合抑制肽
  • 批准号:
    10414909
  • 财政年份:
    2018
  • 资助金额:
    $ 75.02万
  • 项目类别:
Development of therapeutic fusion inhibitor peptides for Measles encephalitis
开发治疗麻疹脑炎的融合抑制肽
  • 批准号:
    10178126
  • 财政年份:
    2018
  • 资助金额:
    $ 75.02万
  • 项目类别:
Development of therapeutic fusion inhibitor peptides for Measles encephalitis
开发治疗麻疹脑炎的融合抑制肽
  • 批准号:
    9973101
  • 财政年份:
    2018
  • 资助金额:
    $ 75.02万
  • 项目类别:
Self-assembling nanoparticles for intranasal delivery of influenza fusion inhibitors
用于鼻内递送流感融合抑制剂的自组装纳米颗粒
  • 批准号:
    9441694
  • 财政年份:
    2016
  • 资助金额:
    $ 75.02万
  • 项目类别:
Development of novel endosome-targeted Ebola virus entry inhibitors as antiviral agents
开发新型内体靶向埃博拉病毒进入抑制剂作为抗病毒药物
  • 批准号:
    9431045
  • 财政年份:
    2016
  • 资助金额:
    $ 75.02万
  • 项目类别:

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