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Adhesion Screening of Dental Implant Materials Using Laser-Driven Acoustic Waves

使用激光驱动声波进行牙科植入材料的粘附力筛选

基本信息

批准号：
10237137
负责人：
Martha Grady
金额：
$ 14.56万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-12 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10237137
关键词：
Acoustics Adhesions Adhesives Antibiotics Area Atomic Force Microscopy Bacteria Bacterial Adhesion Basic Science Biocompatible Materials Biological Biological Testing Calibration Cell Adhesion Cell Count Cells Characteristics Clinical Clinical Sciences Collaborations Communities Data Dental Implants Disease Engineering Environment Evaluation Film Future Goals Growth Human Implant Infection Investigation Kentucky Lasers Light Maintenance Mammalian Cell Measurement Measures Mechanics Medical Medical Device Medical Technology Metabolic Methods Microbial Biofilms Modification Molecular Oral Oral cavity Organism Osseointegration Osteoblasts Outcome Patients Physiologic pulse Physiological Polymers Population Procedures Protocols documentation Recurrence Reporting Research Resolution Safety Saliva Scheme Scientist Side Streptococcus Streptococcus gordonii Streptococcus mutans Streptococcus oralis Streptococcus sanguis Stress Sucrose Surface System Techniques Testing Titanium Translational Research Universities Work absorption base clinical center cohesion design implant material implantable device improved indexing infection risk innovation innovative technologies interest interfacial nanoscale nanosecond novel oral microbial community peri-implantitis preclinical evaluation promoter screening stem technology validation tool translational physician treatment response

项目摘要

ABSTRACT Bacteria accumulation on implants and devices within the oral cavity puts a patient at serious risk for infection. Eradication of established biofilm-forming infections remains difficult, in part because the accumulated bacteria are physiologically and metabolically distinct from the planktonic cells of the same organism. Despite intense efforts in the field, biofilm level response to treatments and changes in environment has been hindered by the lack of robust, quantitative, and accurate biofilm characterization techniques that can be directly correlated to implant surfaces. Accurate biofilm adhesion measurement techniques are necessary because strong biofilm adhesion contributes to biofilm persistence on medical device surfaces. In order to more accurately assess the characteristics and contribution of biofilm adhesion on implant infections, an appropriate film adhesion measurement technique must be developed for evaluation of low cohesive strength-high adhesive strength biofilm-substrate interfaces. The proposed investigation is designed to overcome current limitations in biofilm adhesion measurement techniques by harnessing laser-induced acoustic waves. We recently discovered a new technique that generates stress waves from a pulsed laser is capable of separating a biofilm from a surface. This discovery is especially important for biofilms with low cohesive strengths because existing measurement techniques perform poorly on these biofilms, whereas, our newly discovered technique is well-suited for characterizing these types of biofilms. Controlling the amplitude of the generated stress waves from a pulsed laser enables a direct comparison of the stress required for biofilm detachment. We will assess and optimize the laser spallation technique for quantitative biofilm adhesion strength measurement, evaluate changes in adhesion due to surface treatments (e.g., roughness, polymer coating). Successful completion of this research results in new tools for quantitative adhesion measurement of biofilm-surface interfaces. Implementation of this technology will enable rational selection of implant materials for reduced biofilm adhesion and improved clinical outcomes.

摘要