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Integrative Center for Environmental Microbiomes and Human Health

环境微生物组与人类健康综合中心

基本信息

批准号：
10237912
负责人：
Anthony Amend
金额：
$ 202.14万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10237912
关键词：
Address Affect Animals Bioinformatics Biological Sciences Biology Centers of Research Excellence Characteristics Communities Core Facility Country Dedications Development Ecosystem Environment Environmental Health Exposure to Faculty Fostering Funding Future Generations Genetic Geographic Locations Goals Growth Habitats Hawaiian population Health Home Human Human Microbiome Human Resources Human body Indigenous Infrastructure Insect Vectors Interdisciplinary Study Invertebrates Investigation Island Laboratories Leadership Mentorship Methods Microbe Microscope Modeling Molecular Native Hawaiian Observational Study Pathogenicity Phase Planet Earth Planets Play Quality of life Research Research Personnel Role Science Scientist Sea Senior Scientist Shapes Students Talents Technology Training United States National Institutes of Health Universities Vector-transmitted infectious disease Vision Work base cohort design disease transmission frontier healthspan innovation insight instrumentation land use microbial microbial community microbial genomics microbiome microbiome research microscopic imaging outreach pathogenic microbe predictive modeling professor programs recruit response rural setting success tenure track tool urban setting

项目摘要

Project Summary – OVERALL The goal of the proposed COBRE program is to create an Integrative Center for Environmental Microbiomes and Human Health (ICEMHH) in response to the 2016 announcement of the National Microbiome Initiative (NMI). The NMI was conceived through the recognition that humans are both connected to and reliant upon the microbial communities that constitute the Earth's microbiomes, in the environment as well as the human body. The NIH plays a central role in funding this effort, “..with a particular emphasis on multi-ecosystem comparison studies, and investigation into the design of new tools to explore and understand microbiomes” [NIH Human Microbiome Project]. The focus of ICEMHH is the interface between the microbial environment and human health, and spans state-of-the-art `-omics' methods to ecological analyses and predictive models. The University of Hawaiʻi brings three compelling strengths to microbiome research: the uniquely tractable and scalable landscape of the Hawaiian Islands, an exceptionally qualified biology faculty, including an integrated cohort of recently hired, microbiome-focused, tenure-track, junior professors, and a dedication to the diversity of people that live on the Islands. As the most diverse biome on Earth, Hawaiʻi offers the opportunity to study the effects of ecological gradients on human health, from mountain to sea, and in both urban and rural settings. The proposed projects aim to address two critical and intertwined health problems: the deteriorating environment, and the current spread of insect-vector borne diseases. In this context, proposed research efforts will (i) explore how human health is impacted by exposure to pathogenic microbes in the environment; (ii) examine how the microbiomes of insect vectors affect their transmission of disease within the microcosm of the island of Oʻahu; and, (iii) exploit invertebrate models to provide insight into the underlying cellular, genetic and molecular mechanisms by which microbiomes confer health. In this way, the Center will provide lasting contributions to the State of Hawaiʻi, and beyond.

项目摘要-整体