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Integrative Center for Environmental Microbiomes and Human Health

环境微生物组与人类健康综合中心

基本信息

批准号：
10712771
负责人：
Anthony Amend
金额：
$ 206.66万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10712771
关键词：
Address Affect Animals Biochemistry Biological Sciences Biology Businesses Career Mobility Centers of Research Excellence Chemicals Clinical Clinical Research Collaborations Communities Complement Complex Core Facility Dedications Development Ecology Ecosystem Educational workshop Eligibility Determination Ensure Environment Environmental Health Environmental Impact Environmental Microbiology Exposure to Extramural Activities Faculty Fostering Funding Future Genetic Goals Grant Hawaii Hawaiian Health Health Sciences Histologic Home Human Human Microbiome Human Resources Human body Image Infrastructure Insecta Institution Interdisciplinary Study Internet Invertebrates Investigation Island Knowledge Leadership Link Mentors Mentorship Microbe Modeling Molecular Native Hawaiian Output Pathogenicity Pattern Persons Phase Phylogenetic Analysis Pilot Projects Planet Earth Play Protocols documentation Qualifying Records Research Research Infrastructure Research Personnel Research Project Grants Research Support Resources Role Scientist Sea Seasons Services Standardization System United States National Institutes of Health Universities Variant Work base biobank biomedical resource cohort design experience improved innovation insight member microbial microbial community microbiome microbiome research multidisciplinary novel outreach professor programs recruit research facility resilience response rural setting socioeconomics success symbiont symposium tool transcriptome sequencing urban setting

项目摘要

Project Summary – OVERALL We seek to strengthen and enhance the Integrative Center for Environmental Microbiomes and Human Health (ICEMHH). Our center was established in response to the 2016 announcement of the National Microbiome Initiative (NMI). The NMI was conceived through the recognition that humans are both connected to and reliant upon the microbial communities that constitute the Earth’s microbiomes, in the environment as well as the human body. The NIH plays a central role in funding this effort, “with a particular emphasis on multi-ecosystem comparison studies, and investigation into the design of new tools to explore and understand microbiomes” [NIH Human Microbiome Project]. The focus of the ICEMHH is the interface between the microbial environment and human health, and our research includes clinical, biochemistry and landscape ecology studies. The University of Hawaiʻi brings three compelling strengths to microbiome research: the uniquely tractable and environmentally complexed landscape of the Hawaiian Islands, an exceptionally qualified biology faculty, including an integrated cohort of junior microbiome-focused faculty, and a dedication to the diversity of people that live on the Islands. As the most diverse biome on Earth, Hawaiʻi offers the unique opportunity to study the effects of steep, orthogonal, ecological gradients on human health, vis a vis their microbial symbionts, from mountain to sea, and in both urban and rural settings. The proposed projects aim to address how environmental variables influence microbial assembly, and how, in turn, this impacts host and human health. Our research leverages the natural ecological complexity and phylogenetic diversity of our archipelago to understand the interplay between environmental microbiomes and human health within natural settings. Using invertebrate model hosts and clinical research, we disentangle the mechanisms underlying these landscape-level patterns. Our projects build upon the knowledge, infrastructure and resources developed in Phase 1 to grow center renown, sustainability and capacity. Our long-term goal is that ICEMHH serve as a world-class model for linking environmental microbiology with human health sciences. In this way, the Center will provide lasting contributions to the State of Hawaiʻi, and beyond.

项目概要-总体我们寻求加强和提高环境微生物和人类健康综合中心（ICEMHH）。我们的中心是为了响应2016年国家微生物组的宣布而成立的。倡议（NMI）。NMI的构想是通过认识到人类既相互联系又相互依赖对构成地球微生物组的微生物群落，在环境中以及人体美国国立卫生研究院在资助这项工作中发挥着核心作用，“特别强调多生态系统比较研究，并调查新工具的设计，以探索和了解微生物组” [NIH人类微生物组项目]。ICEMHH的重点是微生物之间的界面，我们的研究包括临床、生物化学和景观生态学问题研究夏威夷大学为微生物组研究带来了三个引人注目的优势：夏威夷群岛的一个易于驾驭和环境复杂的景观，一个非常合格的生物教师，包括一个综合的队列初级微生物组为重点的教师，并致力于多样性，住在岛上的人。作为地球上最多样化的生物群落，夏威夷提供了独特的机会，研究陡峭的，正交的，生态梯度对人类健康的影响，从山区到海洋，从城市到农村，拟议项目旨在解决环境变量如何影响微生物组装，以及这反过来如何影响宿主和人类健康我们的研究利用了我们群岛的自然生态复杂性和系统发育多样性了解自然环境中环境微生物组与人类健康之间的相互作用。使用无脊椎动物模型宿主和临床研究，我们解开这些潜在的机制，高级模式。我们的项目建立在知识，基础设施和资源开发，第一阶段是提高中心的知名度、可持续性和能力。我们的长期目标是，ICEMHH作为一个将环境微生物学与人类健康科学联系起来的世界级模式。这样，中心将为夏威夷州及其他地区做出持久的贡献。

项目成果

期刊论文数量（37）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Stressed snails release Angiostrongylus cantonensis (rat lungworm) larvae in their slime.

DOI：
10.1016/j.onehlt.2023.100658
发表时间：
2023-12
期刊：
ONE HEALTH
影响因子：
5
作者：
Rollins, Randi L.;Medeiros, Matthew C. I.;Cowie, Robert H.
通讯作者：
Cowie, Robert H.

Integrative Systematics and Biogeography of the Hydrozoans (Leptothecata: Eirenidae) Eirene menoni Kramp, 1953 and Eirene lacteoides Kubota and Horita, 1992 from Japan and China with Comments on Pacific Ocean Distributions.

DOI：
10.6620/zs.2023.62-49
发表时间：
2023
期刊：
Zoological studies
影响因子：
1.6
作者：
Gerald L. Crow;B. Holland;Gaku Yamamoto;Shuhei Ikeda;Aya Adachi;Kelley Niide
通讯作者：
Gerald L. Crow;B. Holland;Gaku Yamamoto;Shuhei Ikeda;Aya Adachi;Kelley Niide

Natural Product Discovery by Direct Analysis in Real Time Mass Spectrometry.

通过直接分析在实时质谱法中发现自然产品。