Improving Minority Health in Rheumatic Diseases
改善少数民族风湿病健康
基本信息
- 批准号:10254241
- 负责人:
- 金额:$ 70.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-25 至 2022-09-22
- 项目状态:已结题
- 来源:
- 关键词:ARHGEF5 geneAddressAfrican AmericanAmericasAutoimmuneAvena sativaAwardAwarenessBig DataBiologicalBiometryBiostatistical MethodsChronologyClinicalClinical DataClinical ResearchClinical Research AssociateCollaborationsCommunitiesConnective Tissue DiseasesCoupledDataDevelopmentDiagnosisDiseaseDisease ProgressionEducationElectronic Health RecordEnrollmentFamilyFosteringFoundationsFundingGeneral PopulationGenesGoalsGovernment AgenciesGrantHealthHealth PersonnelHealth ProfessionalHealth PromotionHealth SciencesHearingIndividualKnowledgeLeadershipLinkLupusMedicalMentorsMethodologyMethodsMinorityMinority ParticipationMinority RecruitmentMissionMorbidity - disease rateNational Institute of Arthritis and Musculoskeletal and Skin DiseasesOnline SystemsOutcomeOutcomes ResearchParticipantPathogenesisPatient RecruitmentsPatientsPeer ReviewPersonsPhenotypePilot ProjectsPublic HealthReportingResearchResearch DesignResearch PersonnelResearch Project GrantsResourcesRheumatismRheumatologyRiskSamplingSclerodermaSilverSolidSouth CarolinaSystemic Lupus ErythematosusSystemic SclerodermaTranslational ResearchTrustUniversitiesWolvesWomanbasebiobankclinical careclinical centercommunity engagementcostgene environment interactionhealth disparityhigh riskimprovedinnovationmeetingsminority disparityminority healthmortalitynovelpatient portalprogramsrecruitresearch data disseminationsample collectionsuccesstooltranslational study
项目摘要
PROJECT SUMMARY
We propose a Core Center for Clinical Research at the Medical University of South Carolina entitled Improving
Minority Health in Rheumatic Diseases (IMHRD, pronounced I aM HeaRD). Its mission is to advance knowledge
with respect to the clinical care and health outcomes of African Americans who have, or who are at risk of
developing, systemic lupus erythematosus, scleroderma and other debilitating rheumatic diseases, and thus
improve their health. The center builds on a solid framework of strong leadership in Rheumatology, Biostatistics,
Public Health Sciences and Health Disparities Research coupled with trust and a proven track record of
recruitment of African American patients for clinical research, particularly during the past 4 years in the context
of our NIAMS P60-supported MCRC on Rheumatic Diseases in African Americans. The new CCCR will retain
and enhance the leadership and unique resources of the MCRC, including 3 cores: Administrative, Methodologic,
and Clinical and Community Resource. We seek to impact minority health in rheumatic diseases by: a) providing
well phenotyped research samples from minority lupus and scleroderma patients to an increasing pool of
investigators at MUSC and elsewhere to define specific mechanisms of rheumatic disease pathogenesis and
progression; b) enhancing use of the electronic health record to identify and recruit minority participants in clinical
research projects; c) developing novel methodologic methods for clinical and translational studies as well as in
studies of gene x gene and gene x environment interactions; and d) strengthening community engagement to
enhance awareness of rheumatic diseases and health promotion and increase minority participation in clinical
research. Our Center will offer unique resources and methodologies to other investigators and CCCRs. Specific
aims are to: 1. Foster translational, clinical and outcomes research centered on African Americans with lupus
and scleroderma; 2. Develop novel tools for using the electronic health record (EHR) to expand enrollment and
simplify recruitment of participants in clinical research; 3. Serve as a specialized resource for providing
information and education about these disorders to African American patients and families, their healthcare
providers, the general public, investigators and other health professionals, other CCCRs and government
agencies; 4. Provide well-characterized chronologic samples and associated clinical data to help investigators
identify and understand underlying biologic reasons for differences in risk profiles; 5. Provide quantitative
guidance to the CCCR Research Community while developing novel biostatistical methods and providing
methodologic educational development of trainees and junior investigators; and 6. Provide a competitive pilot
project program with methodologic support and mentoring for recipients. Special strengths of our center include
outstanding institutional commitment, strong partnership with MUSC’s CTSA, a singular culture of trust with the
community, and robust collaboration with the Lupus Foundation of America and DHHS Office of Minority Health.
项目摘要
我们建议在南卡罗来纳州医科大学建立一个临床研究核心中心,
少数民族健康风湿病(IMHRD,发音为I aM HeRD)。它的使命是增进知识
关于非裔美国人的临床护理和健康结果,
发展中的系统性红斑狼疮、硬皮病和其他使人衰弱的风湿性疾病,
改善他们的健康。该中心建立在流变学,生物统计学,
公共卫生科学和健康差异研究加上信任和良好的跟踪记录,
招募非裔美国患者进行临床研究,特别是在过去4年中,
我们的NIAMS P60支持的非裔美国人风湿性疾病MCRC。新的CCCR将保留
并加强MCRC的领导和独特资源,包括3个核心:行政,方法,
临床和社区资源。我们寻求通过以下方式影响风湿性疾病中的少数群体健康:a)提供
从少数狼疮和硬皮病患者到越来越多的
MUSC和其他地方的研究人员确定风湿性疾病发病机制的具体机制,
B)加强使用电子健康记录,以确定和招募少数参与者,
研究项目; c)开发用于临床和转化研究以及
基因x基因和基因x环境相互作用的研究;以及d)加强社区参与,
提高对风湿病和健康促进的认识,增加少数民族参与临床
research.我们的中心将为其他研究人员和CCCR提供独特的资源和方法。具体
目标是:1.促进以患有狼疮的非裔美国人为中心的转化,临床和结果研究
和硬皮病; 2.开发新的工具,使用电子健康记录(EHR)来扩大注册,
简化临床研究参与者的招募; 3.作为一个专门的资源,
向非裔美国人患者和家庭提供有关这些疾病的信息和教育,
提供者、公众、研究者和其他卫生专业人员、其他CCCR和政府
机构; 4.提供良好表征的时序样本和相关临床数据,以帮助研究者
识别和理解风险特征差异的潜在生物学原因; 5.提供定量
指导CCCR研究社区,同时开发新的生物统计方法,
受训人员和初级研究人员的方法学教育发展; 6.提供有竞争力的试点
项目方案,为受援者提供方法上的支持和指导。我们中心的特殊优势包括
杰出的机构承诺,与MUSC的CTSA建立了强有力的合作伙伴关系,
社区,并与美国狼疮基金会和DHHS少数民族健康办公室的大力合作。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gary S Gilkeson其他文献
Podocytes: A Potential Source of Nitric Oxide Production in Murine Lupus Nephritis
- DOI:
10.1016/j.freeradbiomed.2010.10.406 - 发表时间:
2010-01-01 - 期刊:
- 影响因子:
- 作者:
Ahmad K Mashmoushi;Ann F Hofbauer;Gary S Gilkeson;Jim C Oates - 通讯作者:
Jim C Oates
Role of Nitric Oxide in Podocyte Physiology in Lupus Nephritis
- DOI:
10.1016/j.freeradbiomed.2012.10.228 - 发表时间:
2012-11-01 - 期刊:
- 影响因子:
- 作者:
Ahmad K Mashmoushi;Ann F Hofbauer;Gary S Gilkeson;Jim C Oates - 通讯作者:
Jim C Oates
Human SLE variant NCF1-R90H promotes kidney damage and murine lupus through enhanced Tfh2 responses induced by defective efferocytosis of macrophages
- DOI:
10.1136/annrheumdis-2021-220793. - 发表时间:
2022 - 期刊:
- 影响因子:
- 作者:
Linyu Geng;Jian Zhao;Yun Deng;Ivan Molano;Xue Xu;Lingxiao Xu;Phillip Ruiz;Quanzhen Li;Xuebing Feng;Miaojia Zhang;Wenfeng Tan;Diane L Kamen;San-Cheol Bae;Gary S Gilkeson;Lingyun Sun;Betty P Tsao - 通讯作者:
Betty P Tsao
PSS61 - Nitric Oxide Modulation of Redox-Modulated Cytokines in Lupus Nephritis
- DOI:
10.1016/j.freeradbiomed.2013.10.476 - 发表时间:
2013-11-01 - 期刊:
- 影响因子:
- 作者:
Jim C Oates;Ahmad K Mashmoushi;Ann F Hofbauer;Gary S Gilkeson - 通讯作者:
Gary S Gilkeson
Human SLE variant emNCF1/em-R90H promotes kidney damage and murine lupus through enhanced Tfh2 responses induced by defective efferocytosis of macrophages
人类系统性红斑狼疮变异体 emNCF1/em-R90H 通过巨噬细胞吞噬缺陷导致的 Tfh2 反应增强促进肾脏损伤和小鼠狼疮
- DOI:
10.1136/annrheumdis-2021-220793 - 发表时间:
2022-02-01 - 期刊:
- 影响因子:20.600
- 作者:
Linyu Geng;Jian Zhao;Yun Deng;Ivan Molano;Xue Xu;Lingxiao Xu;Phillip Ruiz;Quanzhen Li;Xuebing Feng;Miaojia Zhang;Wenfeng Tan;Diane L Kamen;Sang-Cheol Bae;Gary S Gilkeson;Lingyun Sun;Betty P Tsao - 通讯作者:
Betty P Tsao
Gary S Gilkeson的其他文献
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{{ truncateString('Gary S Gilkeson', 18)}}的其他基金
A Phase II Controlled Trial of Allogeneic Mesenchymal Stem Cells for the Treatment of Refractory Lupus
同种异体间充质干细胞治疗难治性狼疮的 II 期对照试验
- 批准号:
10827646 - 财政年份:2018
- 资助金额:
$ 70.51万 - 项目类别:
A Phase II Controlled Trial of Allogeneic Mesenchymal Stem Cells for the Treatment of Refractory Lupus
同种异体间充质干细胞治疗难治性狼疮的 II 期对照试验
- 批准号:
10356843 - 财政年份:2018
- 资助金额:
$ 70.51万 - 项目类别:
Role of Gut Microbial Translocation in Initiating Autoimmunity
肠道微生物易位在启动自身免疫中的作用
- 批准号:
10291780 - 财政年份:2014
- 资助金额:
$ 70.51万 - 项目类别:
Role of Gut Microbial Translocation in Initiating Autoimmunity
肠道微生物易位在启动自身免疫中的作用
- 批准号:
9564333 - 财政年份:2014
- 资助金额:
$ 70.51万 - 项目类别:
Mesenchymal Stem Cell Therapy for Active Systemic Lupus Erythematosus
间充质干细胞治疗活动性系统性红斑狼疮
- 批准号:
8791443 - 财政年份:2014
- 资助金额:
$ 70.51万 - 项目类别:
Sex Differences in Gut Permeability; Impact on Autoimmunity
肠道渗透性的性别差异;
- 批准号:
8958705 - 财政年份:2014
- 资助金额:
$ 70.51万 - 项目类别:
Sex Differences in Gut Permeability; Impact on Autoimmunity
肠道渗透性的性别差异;
- 批准号:
8820340 - 财政年份:2014
- 资助金额:
$ 70.51万 - 项目类别:
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