Reduced Adipocytes FGF-21 Sensitivity as a Trigger for Type-2 Diabetes Development

脂肪细胞 FGF-21 敏感性降低引发 2 型糖尿病

• 批准号: 10252774
• 负责人: nicholas James
• 金额: $ 25.65万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10252774
• 关键词: Adipocytes; Adult; Affect; Age; Animal Model; Animals; Asians; Basic Science; Bioinformatics; Biometry; Burn injury; Cations; Cell model; Cellular Immunology; Centers of Research Excellence; Child; Childhood; Chronic; Clinical; Clinical Research; Collaborations; Complement; Cultural Diversity; Development; Diabetes Mellitus; Diagnosis; Doctor of Philosophy; Dyslipidemias; Endocrinologist; Environment; Epigenetic Process; Ethnic group; Etiology; Faculty; Functional disorder; Funding; Future; General Population; Genomics; Goals; Grant; Hawaii; Health; Hispanics; Infrastructure; Institution; Insulin Resistance; Internet; Intervention Studies; Kidney; Leadership; Link; Medical; Mentors; Metabolic; Metabolic Diseases; Metabolic syndrome; Metabolism; Molecular; Molecular Biology; Molecular Immunology; Muscle Fibers; Native Hawaiian; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pacific Island Americans; Physicians; Pilot Projects; Population; Positioning Attribute; Prediabetes syndrome; Prevalence; Principal Investigator; Research; Research Personnel; Resources; Risk Factors; Science; Scientist; Structure; System; Translational Research; United States National Institutes of Health; Universities; Vascular calcification; base; clinical epidemiology; cohort; epidemiology study; ethnic diversity; ethnic minority population; experience; fibroblast growth factor 21; glucose transport; health disparity; heart disease risk; high risk; impaired glucose tolerance; improved; institutional capacity; medical schools; meetings; member; metabolic phenotype; multidisciplinary; overweight adults; overweight child; peer; peer coaching; programs; racial diversity; racial minority; recruit; research and development; senior faculty; statistics; success; translational pipeline; translational scientist; translational study

The John A. Burns School of Medicine (JABSOM) at the University of Hawaii (UH) proposes to develop a multidisciplinary Hawaii-based Center of Biomedical Research Excellence (COBRE) in Diabetes Mellitus (DM). This Center will initially span departmental and eventually campus borders to promote the metabolic health of the people of Hawaii and the Pacific region. The Center will leverage Hawaii’s ability to link basic science mechanisms underlying diabetes through translational research. The overall goals are to: 1) Mentor junior investigators studying DM and insulin resistance (IR), 2) Establish a Mentoring Team, 3) Develop a Resource Core that will facilitate DM and IR research, 4) Develop future investigators using a Pilot Project Program, and 5) Recruit an Associate/Full Professor with expertise in translational DM research. The global prevalence of DM continues to increase in parallel with the expanding presence of obesity and overweight adults and children. In the US, the prevalence of DM now affects 27.9 million children and adults (8.9% of US population) (http://www.diabetes.org/diabetes-basics/statistics/). Among racial and ethnic minorities, DM prevalence exceeds that of the US general population by as much as 3-fold. We have shown that among Native Hawaiians (NHs), the prevalence of DM is 22.4% with an additional 15% diagnosed with impaired glucose tolerance or pre-diabetic status. Indeed, prior epidemiological studies on DM, IR, metabolic syndrome (MetS), and heart disease risk factors among NHs and other high risk ethnic populations in Hawaii have provided a rich environment to develop this new COBRE dedicated to understanding the molecular biology underpinnings of DM, IR and the MetS. COBRE funding will be leveraged with institutional funds to accelerate the development of research excellence in DM and IR. The research focus of the Center spans the translational spectrum with one clinical study in Native Hawaiians and Pacific Islanders focused on diabetes and immunoepigenetics. While animal and cell models are being employed in three of the four studies aimed at cation channels, glucose transport in skeletal myocytes and adipocytes, and vascular calcification and dyslipidemia in diabetes and chronic kidney deficiency within the context of IR and DM. New resources being supplemented in this proposal include funding support for a Resources Core with Epigenetics, Animal Metabolic Phenotyping and Cellular Metabolism. Pilot projects are also proposed to fund 2-3 new investigators as the initial cohort of junior investigators progress towards research independence. The JABSOM leadership will also recruit an Associate/Full Professor whose research complements and focuses on translational DM and IR.

夏威夷大学(UH)约翰·A·伯恩斯医学院(JABSOM)建议开发一种 总部设在夏威夷的糖尿病(DM)生物医学研究卓越中心(COBRE)。 该中心最初将跨越部门和最终校园边界，以促进 夏威夷和太平洋地区的人民。该中心将利用夏威夷的能力将基础科学 通过转化性研究研究糖尿病的发病机制。总体目标是：1)指导孩子 研究糖尿病和胰岛素抵抗(IR)的研究人员，2)建立指导团队，3)制定 将促进DM和IR研究的资源核心，4)使用试点开发未来的调查人员 项目计划，以及5)招聘一名具有翻译DM专业知识的副教授/全职教授 研究。 全球糖尿病患病率继续上升，同时肥胖和糖尿病的存在不断扩大 成人和儿童超重。在美国，糖尿病的流行现在影响着2790万儿童和成人 (占美国人口的8.9%)(http://www.diabetes.org/diabetes-basics/statistics/).在种族和民族之间 在少数族裔中，糖尿病的患病率是美国总人口的3倍。我们已经展示了 在夏威夷原住民(NHS)中，DM的患病率为22.4%，另有15%的人被诊断为 糖耐量受损或糖尿病前期状态。事实上，先前关于糖尿病、胰岛素抵抗、代谢的流行病学研究 夏威夷NHS和其他高危民族人群中的综合征(METS)和心脏病危险因素 提供了一个丰富的环境来开发这个致力于了解分子的新科布雷 DM、IR和大都会的生物学基础。 Cobre基金将与机构资金相结合，以加快研究卓越的发展 在DM和IR中。该中心的研究重点涉及翻译领域，其中一项临床研究 夏威夷原住民和太平洋岛民专注于糖尿病和免疫表观遗传学。而动物和细胞 四项研究中有三项针对阳离子通道，即葡萄糖在骨骼中的运输，采用了模型 糖尿病和慢性肾虚患者的心肌细胞和脂肪细胞与血管钙化和血脂异常 在IR和DM的背景下。这项提议补充的新资源包括资金支持 作为表观遗传学、动物代谢表型和细胞代谢的资源核心。试点项目 还提议为2-3名新的调查人员提供资金，因为初级调查人员的初始队列正在向 研究独立性。JABSOM领导层还将招聘一名副教授/正教授，其研究 补充并专注于翻译DM和IR。