Tobacco Regulatory Science Investigating the Intersections of Products with Diverse Populations

烟草监管科学调查产品与不同人群的交叉点

• 批准号: 10252828
• 负责人: Adam Matthew Leventhal
• 金额: $ 399.92万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-19 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10252828
• 关键词: Address; Adolescent; Adoption; Adult; Advertising; Affect; Age; Behavior; Big Data Methods; California; Candy; Cartoons; Characteristics; Cigarette; Cigarette Smoker; Cities; Cohort Studies; Collaborations; Dependence; Device Designs; Devices; Dimensions; Elderly; Electronic cigarette; Ensure; Ethnic Origin; Exposure to; Flavoring; Funding; Future; Goals; Health; Health Benefit; Human; Influentials; Infrastructure; Intercept; Interview; Laboratories; Laboratory Research; Life; Link; Location; Los Angeles; Marketing; Methodology; Mission; Nicotine; Nicotine Dependence; Outcome; Policies; Population; Population Heterogeneity; Process; Regulation; Research; Research Personnel; Research Project Grants; Risk; Sales; Science; Scientist; Services; Smoker; Smoking; Socioeconomic Status; Subgroup; Taste Perception; Testing; Tobacco; Tobacco use; United States Food and Drug Administration; Universities; Variant; Vulnerable Populations; Work; Youth; addiction; career; career development; cohort; combustible cigarette; combustible tobacco; comparative; design; electronic cigarette use; electronic cigarette user; expectation; experience; follow-up; health disparity; infrastructure development; longitudinal analysis; member; middle age; never smoker; non-cigarette tobacco product; non-smoker; sex; smoking cessation; social media; sociodemographics; tobacco control; tobacco products; tobacco regulatory science; uptake; vaping; vapor; young adult

ABSTRACT: Overall Tobacco products are increasingly diverse. Non-cigarette products now garner a large market share; their use and health impact varies across populations. Youth and young adult non-users of tobacco products are vulner- able to initiation of e-cigarettes—a product posing risks both of nicotine dependence and of combustible tobacco uptake. Yet, middle-aged/older adults may switch from combustible to e-cigarette products with potential health benefits. The FDA is required to consider how regulatory policy has differing impact across subgroups to ensure protection of the ‘population as a whole.’ Research addressing population diversity is scant. Through its theme, the Intersections of Products with Populations, the University of Southern California Tobacco Center of Regula- tory Science (USC-TCORS) will conduct research on the use and health effects of specific e-cigarette products across populations. We will study e-cigarette product characteristics and marketing approaches hypothesized to increase tobacco product attraction, use, and addiction in youth and young adult non-smokers and have little impact on tobacco product use in older smokers. These e-cigarette products include: (a) non-tobacco flavorings; (b) constituents and devices that produce large vapor clouds; (c) modifiable devices; (d) device designs not resembling cigarettes; (e) cartoons in packaging and advertising; (f) candy flavors or other youth-oriented mar- keting themes. Product standards and marketing requirements limiting non-combustible products with these features to protect young people, while minimizing collateral effects on switching in adult smokers, would satisfy FDA’s mission to protect the overall population. We will provide evidence to forecast whether such requirements would have equitable impact across vulnerable groups defined by ethnicity, socioeconomic status, and sex that are affected by widening tobacco disparities. Four complementary research projects employing differing meth- odologies will test shared hypotheses on variation of the impact of e-cigarette product diversity on tobacco prod- uct use by age, combustible tobacco use, and sociodemographic diversity: (1) characterization of publicly avail- able social media postings of e-cigarette product characteristics and marketing themes that will be linked pro- spectively with tobacco product use behavior in youth and young adults, (2) intercept interviews with customers at vape shops to assess the impact of scenarios of e-cigarette regulation on tobacco product use, (3) cohort studies of associations of e-cigarette product characteristics and marketing exposures with tobacco product use and dependence across 10 years of early life, (4) laboratory tests of the impact of e-cigarette product character- istics and marketing exposure manipulations on product appeal, abuse liability, and other outcomes. Supported by a Center-wide scientific and career development infrastructure, USC-TCORS will provide the FDA with a robust body of evidence to assess how various regulatory approaches to e-cigarettes are likely to affect the health of vulnerable groups and the whole population. Scientific Domains: Addiction, Behavior, and Marketing.

摘要：总体 烟草产品越来越多样化。非卷烟产品现在占据了很大的市场份额;它们的使用 对健康的影响因人群而异。青少年和年轻的成年人不使用烟草产品是vulner- 能够启动电子烟-一种既有尼古丁依赖风险又有可燃烟草风险的产品 摄取。然而，中老年人可能会从可燃物转向具有潜在健康的电子烟产品 效益FDA需要考虑监管政策如何对亚组产生不同的影响，以确保 保护“全体人民”。关于人口多样性的研究很少。通过它的主题， 产品与人口的交叉点，南加州大学Regula烟草中心- TCORS将对特定电子烟产品的使用和健康影响进行研究 在人群中。我们将研究电子烟产品的特点和营销方法假设， 增加青少年和年轻成年非吸烟者对烟草产品的吸引力、使用和成瘾， 对老年吸烟者使用烟草制品的影响。这些电子烟产品包括：（a）非烟草香料; (b)（c）可修改的装置;（d）装置设计不 （e）包装和广告中的卡通;（f）糖果口味或其他面向青年的商品， 主题。产品标准和营销要求限制不可燃产品与这些 保护年轻人的功能，同时最大限度地减少对成年吸烟者转换的附带影响， FDA的使命是保护所有人群。我们将提供证据来预测这些要求是否 将对按种族、社会经济地位和性别定义的弱势群体产生公平的影响， 受到烟草差距扩大的影响。四个互补的研究项目采用不同的方法- odologies将测试关于电子烟产品多样性对烟草产品影响的变化的共同假设， 按年龄、可燃烟草使用和社会人口多样性划分的吸烟率：（1）公共使用的特征- 能够在社交媒体上发布电子烟产品特性和营销主题， 调查青少年和年轻人的烟草产品使用行为，（2）拦截与客户的访谈 在vape商店评估电子烟法规对烟草产品使用的影响，（3）队列 电子烟产品特性和营销暴露与烟草产品使用的关联研究 和依赖性在10年的早期生活，（4）实验室测试的影响，电子烟产品的特点- 对产品吸引力、滥用责任和其他结果的物流和营销曝光操纵。支持 通过中心范围内的科学和职业发展基础设施，USC-TCORS将为FDA提供 强有力的证据来评估电子烟的各种监管方法可能如何影响 弱势群体和全体人民的健康。科学领域：成瘾，行为和营销。