Antecedents of Adult Physical Health and Cognitive Risks for Alzheimer's Disease and Related Dementias (ADRD) in Adolescent Family Experiences: A Prospective, Longitudinal Adoption Study

青少年家庭经历中成人身体健康和阿尔茨海默氏病及相关痴呆症 (ADRD) 认知风险的前因：一项前瞻性、纵向收养研究

• 批准号: 10464655
• 负责人: Robert F Krueger
• 金额: $ 77.5万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10464655
• 关键词: Address; Adolescence; Adolescent; Adoption; Adult; Adult Children; Affect; Age; Aging; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Biological; Biological Markers; Biological Process; Blood Pressure; Buffers; Cardiovascular system; Child; Child Rearing; Childhood; Code; Cognition; Cognitive; Cohort Studies; Conflict (Psychology); Country; Data; Development; Diagnosis; Disease susceptibility; Elderly; Environment; Environmental Impact; Face; Family; Family Research; Family Study; Future; Generations; Genes; Genetic; Health; Health Status; Heart Diseases; Impaired cognition; Individual; Inflammation; Intake; Link; Literature; Longitudinal Studies; Maintenance; Measures; Mediating; Metabolic syndrome; Mind; Modeling; Outcome; Parent-Child Relations; Parents; Participant; Pathway interactions; Phase; Prospective Studies; Public Health; Reporting; Research; Research Design; Risk; Science; Siblings; Skin; Sum; Symptoms; Testing; Variant; Work; adverse childhood events; age related; allostatic load; behavioral study; caregiving; cognitive enhancement; cognitive function; cognitive reserve; cohort; dementia risk; design; disorder risk; early experience; experience; follow up assessment; follow-up; informant; middle age; mild cognitive impairment; offspring; physical conditioning; prospective; psychosocial; risk variant; social; societal costs; systemic inflammatory response

ABSTRACT Age-related decline in physical and cognitive health are pressing public health concerns. Developmental science shows that variation in adult physical and cognitive health is reliably associated with individuals’ early experiences in their families of origin. Risky families, characterized by greater conflict and lower-quality parenting, tend to disrupt psychosocial and biological functioning, resulting in increased risk for diseases, including Alzheimer’s Disease and Related Dementias (ADRD). Children who receive less warmth, support, and responsiveness from their parents typically have higher inflammation levels, blood pressure, and allostatic load, indicators that predict future cardiovascular problems. These pathways are also implicated in altered midlife cognitive functioning and confer risk for Alzheimer’s Disease and Related Dementias (ADRD). This project takes advantage of an unparalleled opportunity to further this important line of work on the significance of family experiences in adolescence for health outcomes in adulthood by conducting a follow-up into midlife of the Sibling Interaction and Behavior Study (SIBS). SIBS is a longitudinal study of 409 adoptive and 208 non-adoptive families. The offspring in these families have already completed intake (in mid-adolescence), and three follow- up assessments. In the first assessment of SIBS, already coded direct observations of parent-child interactions, as well as parent-reports and child-reports of the quality of the parent-child relationship, were acquired. The availability of these relationship data at a key developmental phase in an adoption cohort provides a strong platform for the addition of follow-up data on the target participants/younger generation (YG; M age = 38 years) and their parents/older generation (OG; M age = 71 years). Our overarching objective is to investigate the degree to which family experiences in adolescence predict key indicators of health in adulthood among adoptive and non-adoptive adults and their aging parents. Specific aims of this project include: AIM 1: Determine the longitudinal effect of adolescent family experiences on later physical health and cognitive functioning in adult children (YG) and their aging parents (OG); AIM 2: Model the environmental impact of adolescent family experiences on later physical health and cognitive functioning; AIM 3: (a) Test whether the effects of family experiences extend to subtle indicators of physical health; (b; exploratory) and are moderated by APOE status.

摘要 与年龄相关的身体和认知健康下降是公共健康的紧迫问题。发展科学 研究表明，成年人身体和认知健康的变化与个人早年的 他们在原籍家庭中的经历。有风险的家庭，其特点是冲突更大，质量更低 养育子女，往往会扰乱心理社会和生物功能，导致疾病风险增加， 包括阿尔茨海默病和相关痴呆症(ADRD)。孩子们得到的温暖、支持和支持更少 父母的反应性通常有更高的炎症水平、血压和变态负荷， 预测未来心血管问题的指标。这些途径也与中年改变有关。 认知功能与阿尔茨海默病和相关痴呆症(ADRD)的风险。这个项目需要 利用一个无与伦比的机会推动这项关于家庭重要性的重要工作 通过对兄弟姐妹的中年进行跟踪，了解青春期对成年健康结果的影响 互动和行为研究(SIBS)。SIB是对409名领养家庭和208名非领养家庭的纵向研究 家人。这些家庭的后代已经完成摄取(在青春期中期)，并有三个后续- 向上评估。在SIBS的第一次评估中，已经对亲子互动的直接观察进行了编码， 以及关于亲子关系质量的父母报告和儿童报告。这个 在采用队列中的关键发展阶段获得这些关系数据可以提供强大的 增加目标参与者/年轻一代(YG；男性=38岁)后续数据的平台 以及他们的父母/老一辈(OG；M年龄=71岁)。我们的首要目标是调查 家庭在青春期的经历可以预测被收养的人和 非领养成年人及其年迈的父母。该项目的具体目标包括：目标1：确定 青春期家庭经历对成年后身体健康和认知功能的纵向影响 儿童(YG)和他们年迈的父母(OG)；目标2：模拟青少年家庭的环境影响 对晚年身体健康和认知功能的体验；目标3：(A)测试家庭的影响 体验延伸到身体健康的微妙指标；(b；探索性)，并受到APOE状态的影响。