Genetic Literacy and Patient-Caregiver Communication of Prognostic Genetic Technology for Localized Prostate Cancer

局部前列腺癌预后基因技术的遗传素养和患者与护理人员的沟通

• 批准号: 10261503
• 负责人: Ewan Kemar Cobran
• 金额: $ 17.2万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-10 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10261503
• 关键词: Address; Adoption; Adult; African American; Alabama; Biochemical; Cancer Biology; Cancer Prognosis; Caregivers; Communication; Communities; Comprehension; Data; Diagnosis; Diffusion of Innovation; Disadvantaged; Education; Educational Background; Educational workshop; Ethnic group; Focus Groups; Funding; Genetic; Genomic medicine; Genomics; Geographic Locations; Goals; Group Interviews; Health Benefit; Health Sciences; Impairment; Incidence; Knowledge; Literature; Louisiana; Low Literacy Population; Low income; Malignant neoplasm of prostate; Maryland; Mentors; Methods; Microarray Analysis; Minority; Mission; Mississippi; National Comprehensive Cancer Network; National Human Genome Research Institute; Neoplasm Metastasis; North Carolina; Nurses; Participant; Patients; Prognosis; Prostate Cancer therapy; Prostatectomy; Public Health; Race; Radiation; Recurrence; Research; Risk; Rural; Rural Population; South Carolina; Structure; Technology; Time; Tissues; Training; Treatment outcome; United States; United States National Institutes of Health; Virginia; base; cancer education; cancer health disparity; design; directed attention; efficacy evaluation; evidence based guidelines; genetic technology; genetic testing; genome sciences; health disparity; health literacy; improved; innovation; literacy; low socioeconomic status; mRNA Expression; mathematical ability; men; mortality; next generation sequencing; novel; novel strategies; oncotype; prognostic; prognostic value; programs; randomized controlled study; skills; theories; treatment planning

Project Summary/Abstract Novel genomic technology, such as microarray analyses and next-generation sequencing, have improved the understanding of prostate cancer biology and prognosis. The National Comprehensive Cancer Network (NCCN), in 2016, recommended that patients and clinicians consider tissue-based genetic tests for localized prostate cancer. However, while much enthusiasm currently exits for the rapidly increasing field of genomic medicine, the use of multi-gene mRNA expression panels raises the potential for further divergence in prostate cancer treatment outcomes by race and low socioeconomic status. We know that health disparities persist in low income groups despite the existence of evidence-based guidelines and that adoption of state-of-the-art methods often lag behind in these groups. The goals of this NCI K01 application are to (1) explore how men with localized prostate cancer and their caregivers comprehend prognostic genetic technology, and (2) examine how an educational video about genetics impacts patient-caregiver communication of prognostic genetic technology. The study rationale is that without direct attention to genomic comprehension, the enthusiasm that exists in the rapidly increasing field of prostate cancer genomic medicine may not translate into health benefits for men with localized prostate cancer. The central hypotheses are (1) men and caregivers with lower levels of education will demonstrate a severe lack of genomic comprehension of tissue-based genetic tests for localized prostate cancer; and (2) tailored prostate cancer education, communication coaching, and a genomic literacy educational video will significantly improve patient-caregiver communication in a low literacy population. The study approach is innovative because it applies a mixed-methods community-engagement research framework to explore how African American and rural White men with localized prostate cancer, comprehend and interpret data generated from genetic technology. The proposed research is significant because of its potential to improve public health by (1) improving the understanding of prognostic genetics in minority, low income, and rural populations, and (2) engage and educate these diverse communities about genomics. The proposed research, in combination with a structured mentoring and training plan that includes didactic course and workshops, is designed to facilitate Dr. Ewan Cobran’s long term goal of developing an independently-funded research program in prostate cancer disparities, consistent with the mission of the NCI.

项目概要/摘要 新型基因组技术，例如微阵列分析和下一代测序，提高了 了解前列腺癌生物学和预后。国家综合癌症网络 （NCCN）在 2016 年建议患者和临床医生考虑对局部进行基于组织的基因检测 前列腺癌。然而，尽管目前人们对快速增长的基因组学领域抱有很大热情 医学上，多基因 mRNA 表达组的使用增加了前列腺进一步分化的可能性 按种族和低社会经济地位划分的癌症治疗结果。我们知道，健康差距依然存在 尽管存在基于证据的指导方针并且采用了最先进的技术，但低收入群体 这些群体的方法往往落后。 此 NCI K01 应用程序的目标是 (1) 探索患有局限性前列腺癌的男性及其症状 护理人员了解预后遗传技术，并且 (2) 检查教育视频如何讲述 遗传学影响患者与护理人员对预后遗传技术的沟通。研究的理由是 如果不直接关注基因组理解，快速增长的领域中存在的热情 前列腺癌基因组医学可能无法转化为局限性前列腺男性的健康益处 癌症。中心假设是 (1) 受教育程度较低的男性和看护者将表现出 对局限性前列腺癌的基于组织的基因检测严重缺乏基因组理解；和（2） 量身定制的前列腺癌教育、沟通辅导和基因组素养教育视频将 显着改善低识字人群中患者与护理人员的沟通。 该研究方法具有创新性，因为它采用了混合方法的社区参与研究 框架来探索非裔美国人和农村白人患有局部前列腺癌， 理解和解释遗传技术产生的数据。拟议的研究意义重大 因为它具有通过以下方式改善公众健康的潜力：(1) 提高对预后遗传学的理解 少数民族、低收入和农村人口，以及 (2) 让这些不同的社区参与并教育他们了解 基因组学。拟议的研究与结构化的指导和培训计划相结合，其中包括 教学课程和研讨会，旨在促进 Ewan Cobran 博士的长期目标，即开发 独立资助的前列腺癌差异研究项目，与该组织的使命一致 国家癌症研究所。