Research Development Core

研究开发核心

• 批准号: 10261437
• 负责人: Ronny Korstanje
• 金额: $ 21.12万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10261437
• 关键词: Affect; Aging; Applications Grants; Award; Biological; Biological Models; Biology of Aging; Budgets; Cells; Collaborations; Communities; Data; Disease; Environment; Faculty; Foundations; Funding; Funding Agency; Genes; Genetic; Geroscience; Goals; Grant; Institution; Laboratories; Lead; Longevity; Mentorship; Molecular; Mus; Pathway interactions; Phenotype; Play; Process; Publications; Research; Research Personnel; Resources; Role; Scientist; Shock; Systems Biology; Talents; Technology; The Jackson Laboratory; Tissues; Work; Writing; age related; biological systems; body system; career; career development; cohort; design; experimental study; healthy aging; innovation; insight; meetings; mouse genetics; programs; research and development; success

RESEARCH DEVELOPMENT CORE PROJECT SUMMARY Understanding the complexity of the aging process and its profound effects across all levels of biological organization will require a strong, interdisciplinary, and diverse supply of talented scientists. The overall goal of The Jackson Laboratory Nathan Shock Center (JAX NSC) Research Development Core is to provide support for career development of junior faculty entering the field of basic aging biology or other investigators who wish to change career direction towards basic aging research. In 2017, the pilot award format was changed from providing funds awarded to two investigators per year ($50,000 each) to an innovative in-kind program where experiments were streamlined for awardees enabling more experiments to be performed for a larger number of investigators within the same budget. During the current funding period, the JAX NSC Research Development Core competitively awarded funding and resources to aging projects across biological systems that resulted in new discoveries, research publications and sources of funding, and helped junior awardees to establish their own independent careers in aging research. Moving forward, these successes will be expanded by providing targeted funding to exciting projects proposed by investigators new to aging research, and by offering a variety of research and intellectual resources to support awardees and other aging investigators in their work. The outstanding institutional resources available at JAX, a premier institution for mouse genetics and systems biology research, will be leveraged to sustain and grow this foundation of researchers at JAX and within the aging community. The Specific Aims are: Aim 1. Fund projects for new investigators in aging research using a competitive pilot award program. Promising investigators new to aging research will be funded through a competitive process so they can generate the data and gain the expertise necessary to support competitive funding applications and a transition to a career in aging biology. Aim 2. Provide resources to support pilot awardees and investigators new to aging research. Access to resources (e.g., aging mice, data, tissues, phenotype platforms, expertise) will be provided to support pilot awardees and other investigators new to aging research. The aging mouse cohorts and phenotyping technologies supported by the JAX NSC present a valuable opportunity for investigators to access material and collect data that might otherwise be prohibitively expensive or difficult to obtain. Aim 3. Provide mentorship and career development opportunities in aging research. Investigators new to aging research will be provided with mentorship by JAX NSC researchers and collaborators. They will also be given opportunities for career development in the aging field via support with the grant writing process, opportunities to participate in aging meetings, and introductions to potential collaborations within the broader aging community. The impact of the Research Development Core is that the pool of investigators devoted to the study of the basic biology of aging will be expanded.

研发核心 项目总结 了解衰老过程的复杂性及其对生物各个层面的深远影响 组织将需要强大的、跨学科的和多样化的有才华的科学家供应。的总目标是 杰克逊实验室内森休克中心(JAX NSC)的研究开发核心是提供支持 为进入基础衰老生物学领域的初级教师或其他希望 改变职业方向，转向基础衰老研究。2017年，试点奖励形式由 每年向两名调查人员提供资金(每人50,000美元)，用于创新的实物方案，其中 简化了获奖者的实验，使更多的实验能够在更多的 调查人员在相同的预算内。在本资助期间，日本宇宙航空研究开发机构NSC研究开发 核心竞争力地向生物系统中的老化项目提供资金和资源，从而导致 新发现、研究出版物和资金来源，并帮助初级获奖者建立他们的 在老龄化研究方面拥有独立的职业生涯。展望未来，这些成功将通过提供 针对老龄化研究新手提出的令人兴奋的项目提供有针对性的资金，并提供各种 研究和智力资源，以支持获奖者和其他老年调查人员的工作。这个 JAX是一家研究小鼠遗传学和系统生物学的顶级机构，它提供了出色的机构资源 研究，将被用来维持和发展JAX和老龄化期间研究人员的这一基础 社区。具体目标是：目标1.为老龄化研究中的新研究者提供资金，使用 竞争性飞行员奖励计划。承诺新接触老龄化研究的调查人员将通过 竞争流程，以便他们能够生成数据并获得支持竞争对手所需的专业知识 资助申请，并过渡到老化生物学的职业生涯。目标2.提供资源支持飞行员 获奖者和研究人员是老龄化研究的新手。访问资源(例如，老化的小鼠、数据、组织， 将提供表型平台、专业知识)，以支持飞行员获奖者和其他新接触老龄化的调查人员 研究。由JAX NSC支持的老化小鼠队列和表型技术提供了一个有价值的 为调查人员提供获取材料和收集数据的机会，否则这些材料可能会令人望而却步 或者很难获得。目标3.在老龄化研究方面提供指导和职业发展机会。 新接触老龄化研究的研究人员将得到JAX NSC研究人员和合作者的指导。 他们还将通过补助金的撰写获得在老龄化领域的职业发展机会 流程、参与老化会议的机会以及对潜在协作的介绍 更广泛的老龄化社区。研究开发核心的影响是，调查员的池 致力于衰老基础生物学的研究将会扩大。