Research Development Core

研发核心 项目摘要 了解衰老过程的复杂性及其对生物学各个层面的深远影响 组织将需要一个强大的，跨学科的和多样化的人才供应的科学家。的总目标 杰克逊实验室内森冲击中心（JAX NSC）研究开发核心将提供支持 对于进入基础衰老生物学领域的初级教师或其他希望 将职业方向转向基础老龄化研究。2017年，试点奖励形式从 每年向两名研究人员提供资金（每人50，000美元），用于一项创新的实物计划， 对获奖者的实验进行了简化，使更多的实验能够为更多的人进行。 在相同的预算范围内。在目前的资助期间，JAX NSC研究开发 核心竞争力授予资金和资源，以老化的项目在整个生物系统，导致 新的发现，研究出版物和资金来源，并帮助初级获奖者建立他们的 在老龄化研究中拥有独立的职业生涯。展望未来，这些成功将通过提供 有针对性的资金，以令人兴奋的项目提出的调查新的老龄化研究，并通过提供各种 研究和智力资源，以支持获奖者和其他老龄化研究人员的工作。的 JAX是小鼠遗传学和系统生物学的首要机构， 研究，将被用来维持和发展JAX和老龄化研究人员的基础 社区具体目标是：目标1。基金项目，为新的调查人员在老龄化研究中使用 有竞争力的飞行员奖励计划有前途的研究人员新的老化研究将通过资助 竞争过程，以便他们可以生成数据并获得支持竞争所需的专业知识 资助申请和过渡到衰老生物学的职业生涯。目标2.提供资源支持试点 获奖者和研究人员新的老龄化研究。获得资源（例如，衰老的老鼠，数据，组织， 表型平台，专业知识）将提供支持试点获奖者和其他研究人员新的老龄化 research. JAX NSC支持的衰老小鼠队列和表型分析技术提供了一个有价值的 调查人员有机会访问材料和收集数据，否则可能会非常昂贵 或难以获得。目标3。提供老龄化研究方面的导师和职业发展机会。 JAX NSC研究人员和合作者将为新的老龄化研究人员提供指导。 他们还将通过资助写作获得老龄领域职业发展的机会 过程，参加老龄化会议的机会，以及介绍 更广泛的老龄化社区。研究开发核心的影响是， 致力于研究衰老的基础生物学将得到扩大。

RESEARCH DEVELOPMENT CORE PROJECT SUMMARY Understanding the complexity of the aging process and its profound effects across all levels of biological organization will require a strong, interdisciplinary, and diverse supply of talented scientists. The overall goal of The Jackson Laboratory Nathan Shock Center (JAX NSC) Research Development Core is to provide support for career development of junior faculty entering the field of basic aging biology or other investigators who wish to change career direction towards basic aging research. In 2017, the pilot award format was changed from providing funds awarded to two investigators per year ($50,000 each) to an innovative in-kind program where experiments were streamlined for awardees enabling more experiments to be performed for a larger number of investigators within the same budget. During the current funding period, the JAX NSC Research Development Core competitively awarded funding and resources to aging projects across biological systems that resulted in new discoveries, research publications and sources of funding, and helped junior awardees to establish their own independent careers in aging research. Moving forward, these successes will be expanded by providing targeted funding to exciting projects proposed by investigators new to aging research, and by offering a variety of research and intellectual resources to support awardees and other aging investigators in their work. The outstanding institutional resources available at JAX, a premier institution for mouse genetics and systems biology research, will be leveraged to sustain and grow this foundation of researchers at JAX and within the aging community. The Specific Aims are: Aim 1. Fund projects for new investigators in aging research using a competitive pilot award program. Promising investigators new to aging research will be funded through a competitive process so they can generate the data and gain the expertise necessary to support competitive funding applications and a transition to a career in aging biology. Aim 2. Provide resources to support pilot awardees and investigators new to aging research. Access to resources (e.g., aging mice, data, tissues, phenotype platforms, expertise) will be provided to support pilot awardees and other investigators new to aging research. The aging mouse cohorts and phenotyping technologies supported by the JAX NSC present a valuable opportunity for investigators to access material and collect data that might otherwise be prohibitively expensive or difficult to obtain. Aim 3. Provide mentorship and career development opportunities in aging research. Investigators new to aging research will be provided with mentorship by JAX NSC researchers and collaborators. They will also be given opportunities for career development in the aging field via support with the grant writing process, opportunities to participate in aging meetings, and introductions to potential collaborations within the broader aging community. The impact of the Research Development Core is that the pool of investigators devoted to the study of the basic biology of aging will be expanded.