Research Development Core

研究开发核心 项目概要 了解衰老过程的复杂性及其对各个生物学层面的深远影响 组织将需要强大的、跨学科的、多样化的有才华的科学家。总体目标为 杰克逊实验室内森休克中心 (JAX NSC) 研究开发核心将提供支持 用于进入基础衰老生物学领域的初级教师或其他希望的研究人员的职业发展 将职业方向转向基础衰老研究。 2017年，试点奖励形式由 每年向两名研究人员提供资金（每人 50,000 美元）用于创新实物计划，其中 为获奖者简化了实验，从而可以对更多数量的实验进行更多实验 调查人员在相同的预算内。在当前资助期内，JAX NSC 研究开发 核心竞争性地为跨生物系统的老化项目提供资金和资源，从而导致 新发现、研究出版物和资金来源，并帮助初级获奖者建立自己的 在衰老研究方面拥有独立的职业生涯。展望未来，这些成功将通过提供 有针对性地为老龄化研究新手提出的令人兴奋的项目提供资金，并提供各种 的研究和智力资源，以支持获奖者和其他老龄化研究人员的工作。的 JAX 拥有出色的机构资源，JAX 是小鼠遗传学和系统生物学领域的一流机构 研究，将被用来维持和发展 JAX 和老龄化领域研究人员的基础 社区。具体目标是： 目标 1. 为老龄化研究的新研究者提供资金项目 竞争性飞行员奖励计划。刚接触衰老研究的有前途的研究人员将通过一个项目获得资助 竞争过程，以便他们可以生成数据并获得支持竞争所需的专业知识 资助申请并过渡到衰老生物学的职业生涯。目标 2. 提供资源支持试点 刚接触衰老研究的获奖者和研究人员。获取资源（例如，衰老的小鼠、数据、组织、 将提供表型平台、专业知识，以支持试点获奖者和其他新接触老龄化的研究人员 研究。 JAX NSC 支持的衰老小鼠群体和表型分析技术提供了宝贵的 调查人员有机会获取材料和收集数据，否则这些材料和数据可能会非常昂贵 或难以获得。目标 3. 提供老龄化研究方面的指导和职业发展机会。 JAX NSC 研究人员和合作者将为刚接触衰老研究的研究人员提供指导。 通过资助写作的支持，他们还将获得在老龄化领域职业发展的机会 流程、参加老龄化会议的机会以及介绍老龄化领域内的潜在合作 更广泛的老龄化社区。研究开发核心的影响在于，研究人员池 致力于衰老基础生物学的研究将得到扩展。

RESEARCH DEVELOPMENT CORE PROJECT SUMMARY Understanding the complexity of the aging process and its profound effects across all levels of biological organization will require a strong, interdisciplinary, and diverse supply of talented scientists. The overall goal of The Jackson Laboratory Nathan Shock Center (JAX NSC) Research Development Core is to provide support for career development of junior faculty entering the field of basic aging biology or other investigators who wish to change career direction towards basic aging research. In 2017, the pilot award format was changed from providing funds awarded to two investigators per year ($50,000 each) to an innovative in-kind program where experiments were streamlined for awardees enabling more experiments to be performed for a larger number of investigators within the same budget. During the current funding period, the JAX NSC Research Development Core competitively awarded funding and resources to aging projects across biological systems that resulted in new discoveries, research publications and sources of funding, and helped junior awardees to establish their own independent careers in aging research. Moving forward, these successes will be expanded by providing targeted funding to exciting projects proposed by investigators new to aging research, and by offering a variety of research and intellectual resources to support awardees and other aging investigators in their work. The outstanding institutional resources available at JAX, a premier institution for mouse genetics and systems biology research, will be leveraged to sustain and grow this foundation of researchers at JAX and within the aging community. The Specific Aims are: Aim 1. Fund projects for new investigators in aging research using a competitive pilot award program. Promising investigators new to aging research will be funded through a competitive process so they can generate the data and gain the expertise necessary to support competitive funding applications and a transition to a career in aging biology. Aim 2. Provide resources to support pilot awardees and investigators new to aging research. Access to resources (e.g., aging mice, data, tissues, phenotype platforms, expertise) will be provided to support pilot awardees and other investigators new to aging research. The aging mouse cohorts and phenotyping technologies supported by the JAX NSC present a valuable opportunity for investigators to access material and collect data that might otherwise be prohibitively expensive or difficult to obtain. Aim 3. Provide mentorship and career development opportunities in aging research. Investigators new to aging research will be provided with mentorship by JAX NSC researchers and collaborators. They will also be given opportunities for career development in the aging field via support with the grant writing process, opportunities to participate in aging meetings, and introductions to potential collaborations within the broader aging community. The impact of the Research Development Core is that the pool of investigators devoted to the study of the basic biology of aging will be expanded.