Research Education Component

研究教育部分

• 批准号: 10263690
• 负责人: Kyle M Walsh
• 金额: $ 23.99万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263690
• 关键词: Address; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; American; American Indians; Basic Science; Biological Markers; Biology of Aging; Capsicum; Clinic; Clinical; Clinical Investigator; Clinical Research; Collaborations; Communication; Community Developments; Development; Discipline; Doctor of Philosophy; Educational Curriculum; Educational workshop; Environment; Exposure to; Face; Faculty; Fostering; Foundations; Future; Goals; Health; Historically Black Colleges and Universities; Institution; Journals; Knowledge; Learning; Longevity; Manuscripts; Mediating; Medical; Medical Research; Medical Students; Mentors; Mentorship; Neurosciences; North Carolina; Outcome; Pathologic; Pathology; Patient Recruitments; Population; Positioning Attribute; Postdoctoral Fellow; Preventive measure; Research; Research Design; Research Ethics; Research Personnel; Research Support; Research Training; Resources; Sampling; Science; Scientist; Site; Specimen; Statistical Data Interpretation; Students; Talents; Training; Training Programs; Training and Education; Translational Research; Underserved Population; Universities; age related; base; biobank; career; disparity reduction; education research; experience; health care delivery; improved; innovation; insight; interdisciplinary collaboration; interest; medical specialties; multidisciplinary; next generation; novel; online course; posters; programs; research data dissemination; responsible research conduct; rural healthcare; summer research; symposium; targeted delivery; training opportunity

ABSTRACT - Research Education Component The primary goal of the Duke/UNC Alzheimer’s Disease Research Center (ADRC) Research Education Component (REC) is to develop future leaders in Alzheimer’s disease (AD) and AD-related dementias (AD+ADRD) research, including within the Center’s theme of identifying age-related changes across the lifespan that mediate the development, progression and experience of AD. There are unique challenges facing AD+ADRD research, including limited training in researchprinciples, a lack of early-career exposure to AD+ADRD research, and research silos that impede knowledge transfer between basic and clinical investigators. To overcome these challenges, the REC research training program will broadly disseminate a foundational AD+ADRD research curriculum spanning both basic and clinical research, delivered to five universities across North Carolina and made available to the public (Aim 1). In addition to delivering broad cross-campus AD+ADRD research education, the REC will solicit “REC Scholar” applications and select 2-4 scholars annually from a diverse pool of talented early-career AD+ADRD investigators (Aim 2). REC Scholars will receive intensive research training and tailored professional development under the guidance of a faculty mentorship team comprised of a clinical researcher and a basic scientist. The REC will expand the reach of its training program by leveraging existing training assets at Duke and UNC (e.g., Duke’s “Creating AD Researchers for the Next Generation” STARR Program (R38), UNC’s “Summer Research Training in Aging for Medical Students” (T35) and Duke’s Claude D. Pepper Older Americans Independence Center and Edward R. Roybal Center). The REC’s close integration with the other Duke/UNC ADRC cores provides synergistic interactions with key research training opportunities in specimen biobanking, statistical analysis, study design, pathologic sample analysis, patient recruitment, and research dissemination. The REC will diversify AD+ADRD researcher perspectives and the workforce by partnering with UNC Pembroke (a designated historically American Indian university), NC Central University (an historically black university), and East Carolina University (an institution with expertise in rural healthcare delivery) (Aim 3). Investigators and trainees at these institutions will participate in monthly research colloquia, the online curriculum, monthly journal clubs, research consultancies that leverage Duke/UNC expertise to augment AD+ADRD research at other sites, and the annual Symposium for Learning about Alzheimer’s disease-related Medical research at Duke and UNC (SLAM-DUNC), hosted by each institution in turn. REC programming will foster interest in AD+ADRD research and cultivate the multidisciplinary expertise needed in its next generation of leaders. By fostering interactions among investigators from different disciplines and backgrounds through the REC’s innovative and inclusive programming, the REC will develop new AD+ADRD researchers prepared to engage in interdisciplinary collaborations aimed at improving health outcomes and reducing disparities by bringing novel treatments to the clinic and novel preventive measures to the population.

摘要 - 研究教育部分 杜克大学/北卡罗来纳大学阿尔茨海默病研究中心 (ADRC) 研究教育的主要目标 组成部分 (REC) 旨在培养阿尔茨海默病 (AD) 和 AD 相关痴呆症的未来领导者 (AD+ADRD) 研究，包括在该中心的主题内识别整个生命周期中与年龄相关的变化 介导 AD 的发展、进展和经历。面临着独特的挑战 AD+ADRD 研究，包括有限的研究原理培训、缺乏早期职业接触 AD+ADRD 研究以及阻碍基础研究人员和临床研究人员之间知识转移的研究孤岛。 为了克服这些挑战，REC 研究培训计划将广泛传播基础知识 AD+ADRD 研究课程涵盖基础研究和临床研究，交付给全国五所大学 北卡罗来纳州并向公众开放（目标 1）。除了提供广泛的跨校区 AD+ADRD 研究教育，REC将征求“REC学者”申请，并每年从研究教育中选出2-4名学者 多样化的早期职业 AD+ADRD 研究者人才库（目标 2）。 REC 学者将接受强化培训 在教师导师团队的指导下进行研究培训和量身定制的专业发展 由一名临床研究员和一名基础科学家组成。 REC 将扩大其培训计划的范围 通过利用杜克大学和北卡罗来纳大学的现有培训资产（例如杜克大学的“为下一代培养 AD 研究人员”） Generation”STARR 计划 (R38)、北卡罗来纳大学“医学生老龄化夏季研究培训”(T35) 以及杜克大学的克劳德·D·佩珀美国老年人独立中心和爱德华·R·罗伊巴尔中心）。这 REC 与其他 Duke/UNC ADRC 内核的紧密集成提供了与关键的协同交互 样本生物样本库、统计分析、研究设计、病理样本方面的研究培训机会 分析、患者招募和研究传播。 REC 将使 AD+ADRD 研究人员多元化 通过与北卡罗来纳大学彭布罗克分校（指定的历史上美洲印第安人）合作，了解观点和劳动力 大学）、北卡罗来纳中央大学（一所历史悠久的黑人大学）和东卡罗来纳大学（一所机构） 具有农村医疗保健提供方面的专业知识）（目标 3）。这些机构的研究人员和实习生将参加 在每月的研究座谈会、在线课程、每月的期刊俱乐部、研究咨询机构中， 杜克大学/北卡罗来纳大学的专业知识，以增强其他地点的 AD+ADRD 研究，以及年度学习研讨会 关于杜克大学和北卡罗来纳大学 (SLAM-DUNC) 的阿尔茨海默病相关医学研究，由各机构主办 反过来。 REC 项目将培养对 AD+ADRD 研究的兴趣并培养多学科专业知识 需要下一代领导人。通过促进不同学科研究人员之间的互动 通过 REC 的创新和包容性计划，REC 将开发新的 AD+ADRD 研究人员准备开展旨在改善健康的跨学科合作 通过将新的治疗方法引入临床并采取新的预防措施来减少差异 人口。