Research Education Component

摘要-研究教育部分 杜克/杜克阿尔茨海默病研究中心（ADRC）研究教育的主要目标 组成部分（REC）是发展阿尔茨海默病（AD）和AD相关痴呆症的未来领导者 (AD+ADRD）研究，包括该中心的主题，即确定整个生命周期中与年龄相关的变化 介导AD的发展、进展和经历。我们面临着独特的挑战 AD+ADRD研究，包括研究原则的培训有限，缺乏早期职业接触， AD+ADRD研究，以及阻碍基础和临床研究者之间知识转移的研究孤岛。 为了克服这些挑战，REC研究培训计划将广泛传播一个基本的 AD+ADRD研究课程涵盖基础和临床研究，提供给五所大学， 北卡罗来纳州，并提供给公众（目标1）。除了提供广泛的跨校园AD+ADRD 研究教育，REC将征求“REC学者”的申请，并选择2-4学者每年从一个 多样化的有才华的早期职业AD+ADRD研究者库（目标2）。REC学者将获得密集的 在教师指导团队的指导下进行研究培训和量身定制的专业发展 由一名临床研究员和一名基础科学家组成。REC将扩大其培训计划的范围 通过利用杜克和杜克大学的现有培训资产（例如，杜克的“为下一代创造广告研究人员” 一代”STARR计划（R38），ESTA的“夏季研究培训医学生老龄化”（T35） 还有杜克的克劳德·D佩珀老年美国人独立中心和爱德华R。Roybal Center）。的 REC与其他杜克/杜克ADRC核心的紧密集成提供了与关键 标本生物库、统计分析、研究设计、病理样本方面的研究培训机会 分析、患者招募和研究传播。REC将使AD+ADRD研究人员多样化 观点和劳动力的合作，与彭布罗克（一个指定的历史上美国印第安人 大学），北卡罗来纳中央大学（一所历史悠久的黑人大学）和东卡罗莱纳大学（一所机构 （三）农村医疗卫生服务（目标3）。这些机构的调查人员和受训人员将参加 在每月的研究座谈会，在线课程，每月的期刊俱乐部，研究咨询， 杜克/杜克大学的专业知识，以增加在其他网站的AD+ADRD研究，以及年度研讨会的学习 关于阿尔茨海默病相关的医学研究在杜克和杜克大学（SLAM-DUNK），由每个机构主办 依次REC计划将培养对AD+ADRD研究的兴趣，并培养多学科的专业知识 需要下一代领导人。通过促进不同学科研究者之间的互动， 通过REC的创新和包容性规划，REC将开发新的 AD+ADRD研究人员准备参与旨在改善健康的跨学科合作 通过将新的治疗方法引入临床和采取新的预防措施， 人口。

ABSTRACT - Research Education Component The primary goal of the Duke/UNC Alzheimer’s Disease Research Center (ADRC) Research Education Component (REC) is to develop future leaders in Alzheimer’s disease (AD) and AD-related dementias (AD+ADRD) research, including within the Center’s theme of identifying age-related changes across the lifespan that mediate the development, progression and experience of AD. There are unique challenges facing AD+ADRD research, including limited training in researchprinciples, a lack of early-career exposure to AD+ADRD research, and research silos that impede knowledge transfer between basic and clinical investigators. To overcome these challenges, the REC research training program will broadly disseminate a foundational AD+ADRD research curriculum spanning both basic and clinical research, delivered to five universities across North Carolina and made available to the public (Aim 1). In addition to delivering broad cross-campus AD+ADRD research education, the REC will solicit “REC Scholar” applications and select 2-4 scholars annually from a diverse pool of talented early-career AD+ADRD investigators (Aim 2). REC Scholars will receive intensive research training and tailored professional development under the guidance of a faculty mentorship team comprised of a clinical researcher and a basic scientist. The REC will expand the reach of its training program by leveraging existing training assets at Duke and UNC (e.g., Duke’s “Creating AD Researchers for the Next Generation” STARR Program (R38), UNC’s “Summer Research Training in Aging for Medical Students” (T35) and Duke’s Claude D. Pepper Older Americans Independence Center and Edward R. Roybal Center). The REC’s close integration with the other Duke/UNC ADRC cores provides synergistic interactions with key research training opportunities in specimen biobanking, statistical analysis, study design, pathologic sample analysis, patient recruitment, and research dissemination. The REC will diversify AD+ADRD researcher perspectives and the workforce by partnering with UNC Pembroke (a designated historically American Indian university), NC Central University (an historically black university), and East Carolina University (an institution with expertise in rural healthcare delivery) (Aim 3). Investigators and trainees at these institutions will participate in monthly research colloquia, the online curriculum, monthly journal clubs, research consultancies that leverage Duke/UNC expertise to augment AD+ADRD research at other sites, and the annual Symposium for Learning about Alzheimer’s disease-related Medical research at Duke and UNC (SLAM-DUNC), hosted by each institution in turn. REC programming will foster interest in AD+ADRD research and cultivate the multidisciplinary expertise needed in its next generation of leaders. By fostering interactions among investigators from different disciplines and backgrounds through the REC’s innovative and inclusive programming, the REC will develop new AD+ADRD researchers prepared to engage in interdisciplinary collaborations aimed at improving health outcomes and reducing disparities by bringing novel treatments to the clinic and novel preventive measures to the population.