Clinical Core

临床核心

• 批准号: 10264662
• 负责人: John M Olichney
• 金额: $ 109.68万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264662
• 关键词: Affect; African American; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Asians; Assessment tool; Autopsy; Awareness; Behavioral; Biological; Biological Markers; Blood; Brain; Brain imaging; Caring; Cessation of life; Classification; Clinical; Clinical Data; Cognition; Cognitive; Cognitive aging; Collaborations; Collection; Communities; Complex; Consent; DNA; Data; Data Collection; Databases; Dementia; Development; Diagnosis; Diagnostic; Disease; Education; Elderly; Enrollment; Epidemiology; Exposure to; Family; Goals; Heterogeneity; Hispanics; Image; Immigration; Impaired cognition; Impairment; Individual; Interdisciplinary Study; Intervention Trial; Language; Latinx; Leadership; Longitudinal cohort; Magnetic Resonance Imaging; Measurement; Methods; Mission; Pathology; Phenotype; Plasma; Population; Population Heterogeneity; Population Study; Positron-Emission Tomography; Prevalence; Prevention; Protocols documentation; Psychometrics; Public Health; RNA; Research; Research Methodology; Research Personnel; Resources; Retrieval; Risk Factors; Sampling; Science; Specimen; Standardization; Training; Translating; Translational Research; Underrepresented Populations; Vascular Diseases; Work; aging brain; biomarker development; brain health; brain research; clinical Diagnosis; clinical diagnostics; cohort; daily functioning; effective therapy; epidemiology study; experience; follow-up; innovation; modifiable risk; multidisciplinary; multiple data sources; neuroimaging; novel; outcome prediction; patient engagement; protective factors; racial and ethnic disparities; recruit; social; social culture; socioeconomics; success; tool; underserved community; vascular contributions; vascular risk factor

PROJECT SUMMARY - Clinical Core (CC) The mission of the UC Davis Alzheimer’s Disease Research Center (UCD ADRC) is to advance the science of healthy brain aging among diverse populations while caring for those affected by dementia. This mission and the work of the Clinical Core (CC) contribute to many of the milestones and goals set forth by the National Alzheimer’s Disease Plan (NAPA). The CC is essential to the UCD ADRC’s mission, in part, by maintaining the Longitudinal Diversity Cohort (LDC), a large, highly diverse group of older adults followed annually through autopsy, and by overseeing the collection of the multiple sources of data obtained from these individuals. This cohort is highly unique among ADRCs in that it includes substantial numbers of older adults from two of the largest underrepresented groups in the U.S.: African Americans (~25% of the cohort) and Hispanics (~25%). This diversity translates into heterogeneity of cognitive trajectories, incident Alzheimer’s disease and related dementias (ADRD), risk factors and lifecourse experiences, and the prevalence of vascular risk factors consistent with community populations, thereby providing a valuable resource for studying both AD and mixed pathologies. The sample is similarly diverse in terms of education (range of 0-20 years), native language, socioeconomic and immigration status, and exposure to adversity. Through primarily community recruitment, the UCD ADRC enrolls cognitively normal and mildly impaired individuals to study cognitive decline and the transition to various stages of disease. This facilitates identification of novel modifiable risk and protective factors and biomarker development, both of which have implications for dementia prevention. All individuals in the LDC are characterized at an uncommonly rich level (well beyond the UDS) that includes neuroimaging and blood biomarkers, annual diagnostic classification, psychometrically rigorous measurement of cognition and daily function (separate from measurements used for diagnosis) and extensive collection of lifecourse sociocultural and behavioral data. The LDC is a well established cohort with extensive data from both active (n=425) and inactive cases (n>950), some with 15+ years of follow-up. All of this data has been integrated into the UCD ADRC database that provides an easily accessible research resource widely utilized by researchers both within and outside of our Center. Data from the LDC has contributed to innovative new research findings in many areas including enhancing our understanding of ethnic/racial disparities in cognitive aging and the contributions of vascular disease to brain health, among many other contributions. In addition, the CC has the added advantage of creating bi-directional translational relationships with epidemiological studies aimed at understanding the complex determinants of ADRD and accelerating the development of effective treatment and prevention across the ADRD spectrum.

项目总结-临床核心（CC） 加州大学戴维斯分校阿尔茨海默病研究中心（UCD ADRC）的使命是推进以下科学： 健康的大脑在不同人群中老化，同时照顾那些受痴呆症影响的人。这次使命和 临床核心（CC）的工作有助于实现许多里程碑和目标， 阿尔茨海默病计划（NAPA）。CC对UCD ADRC的使命至关重要，部分是通过维护 纵向多样性队列（LDC），一个大型的，高度多样化的老年人群体，每年随访一次， 尸检，并通过监督从这些人获得的多个数据来源的收集。这 队列在ADRC中是非常独特的，因为它包括来自两个国家的大量老年人。 美国最大的代表性不足的群体：非裔美国人（约25%）和西班牙裔（约25%）。 这种多样性转化为认知轨迹的异质性，阿尔茨海默病及其相关疾病的发病率。 痴呆（ADRD），危险因素和生活经历，以及血管危险因素的患病率 与社区人群一致，从而为研究AD和混合AD提供了宝贵的资源。 病理学样本在教育（0-20年）、母语、 社会经济和移民状况，以及面对逆境的情况。主要通过社区招募， UCD ADRC招募认知正常和轻度受损的个体来研究认知衰退， 疾病的各个阶段。这有助于识别新的可改变的风险， 因素和生物标志物的发展，这两者都对痴呆症的预防有影响。内的所有人士 最不发达国家的特点是在一个不寻常的丰富水平（远远超过UDS），包括神经成像和 血液生物标志物，年度诊断分类，认知的心理测量严格测量， 日常功能（与用于诊断的测量分开）和广泛收集生命过程 社会文化和行为数据。最不发达国家是一个完善的队列，具有来自活跃的 （n=425）和非活动病例（n>950），其中一些病例随访时间超过15年。所有这些数据都被整合到 UCD ADRC数据库，提供了一个易于访问的研究资源，广泛使用的研究人员 在我们的中心内外。来自最不发达国家的数据为创新的新研究成果做出了贡献 在许多领域，包括提高我们对认知老化中种族/种族差异的理解， 血管疾病对大脑健康的贡献，以及许多其他贡献。此外，消委会亦设有 与流行病学研究建立双向转化关系的额外优势， 了解ADRD的复杂决定因素并加速开发有效治疗方法 和ADRD谱的预防。