Clinical Core

临床核心

• 批准号: 10666434
• 负责人: John M Olichney
• 金额: $ 111.77万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666434
• 关键词: Acceleration; Affect; African American population; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Asian; Assessment tool; Autopsy; Awareness; Behavioral; Biological; Biological Markers; Black race; Blood; Brain; Brain imaging; Caring; Cessation of life; Classification; Clinical; Clinical Data; Cognition; Cognitive; Cognitive aging; Collaborations; Collection; Communities; Complex; Consent; DNA; Data; Data Collection; Databases; Dementia; Development; Diagnosis; Diagnostic; Disease; Education; Elderly; Enrollment; Epidemiology; Ethnic Origin; Exposure to; Family; Goals; Heterogeneity; Hispanic Populations; Image; Immigration; Impaired cognition; Impairment; Individual; Interdisciplinary Study; Intervention Trial; Language; Latinx; Leadership; Life Cycle Stages; Longitudinal cohort; Measurement; Methods; Mission; Outcome; Pathology; Phenotype; Plasma; Population; Population Heterogeneity; Population Study; Positron-Emission Tomography; Prevalence; Prevention; Protocols documentation; Psychometrics; Public Health; RNA; Research; Research Methodology; Research Personnel; Resources; Retrieval; Risk Factors; Sampling; Science; Specimen; Standardization; Training; Translating; Translational Research; Underrepresented Populations; Vascular Diseases; Work; aging brain; biomarker development; brain health; brain magnetic resonance imaging; brain research; clinical diagnosis; clinical diagnostics; cohort; daily functioning; dementia risk; effective therapy; epidemiology study; ethnic disparity; experience; follow-up; innovation; modifiable risk; multidisciplinary; multiple data sources; neuroimaging; neuropathology; novel; patient engagement; protective factors; racial disparity; recruit; social; social culture; socioeconomics; success; underserved community; vascular contributions; vascular risk factor

PROJECT SUMMARY - Clinical Core (CC) The mission of the UC Davis Alzheimer’s Disease Research Center (UCD ADRC) is to advance the science of healthy brain aging among diverse populations while caring for those affected by dementia. This mission and the work of the Clinical Core (CC) contribute to many of the milestones and goals set forth by the National Alzheimer’s Disease Plan (NAPA). The CC is essential to the UCD ADRC’s mission, in part, by maintaining the Longitudinal Diversity Cohort (LDC), a large, highly diverse group of older adults followed annually through autopsy, and by overseeing the collection of the multiple sources of data obtained from these individuals. This cohort is highly unique among ADRCs in that it includes substantial numbers of older adults from two of the largest underrepresented groups in the U.S.: African Americans (~25% of the cohort) and Hispanics (~25%). This diversity translates into heterogeneity of cognitive trajectories, incident Alzheimer’s disease and related dementias (ADRD), risk factors and lifecourse experiences, and the prevalence of vascular risk factors consistent with community populations, thereby providing a valuable resource for studying both AD and mixed pathologies. The sample is similarly diverse in terms of education (range of 0-20 years), native language, socioeconomic and immigration status, and exposure to adversity. Through primarily community recruitment, the UCD ADRC enrolls cognitively normal and mildly impaired individuals to study cognitive decline and the transition to various stages of disease. This facilitates identification of novel modifiable risk and protective factors and biomarker development, both of which have implications for dementia prevention. All individuals in the LDC are characterized at an uncommonly rich level (well beyond the UDS) that includes neuroimaging and blood biomarkers, annual diagnostic classification, psychometrically rigorous measurement of cognition and daily function (separate from measurements used for diagnosis) and extensive collection of lifecourse sociocultural and behavioral data. The LDC is a well established cohort with extensive data from both active (n=425) and inactive cases (n>950), some with 15+ years of follow-up. All of this data has been integrated into the UCD ADRC database that provides an easily accessible research resource widely utilized by researchers both within and outside of our Center. Data from the LDC has contributed to innovative new research findings in many areas including enhancing our understanding of ethnic/racial disparities in cognitive aging and the contributions of vascular disease to brain health, among many other contributions. In addition, the CC has the added advantage of creating bi-directional translational relationships with epidemiological studies aimed at understanding the complex determinants of ADRD and accelerating the development of effective treatment and prevention across the ADRD spectrum.

项目摘要 - 临床核心 (CC) 加州大学戴维斯分校阿尔茨海默病研究中心 (UCD ADRC) 的使命是推进阿尔茨海默氏症研究的科学发展 不同人群的大脑健康老化，同时照顾痴呆症患者。这个使命和 临床核心 (CC) 的工作为国家制定的许多里程碑和目标做出了贡献 阿尔茨海默病计划 (NAPA)。 CC 对于 UCD ADRC 的使命至关重要，部分原因是维持 纵向多样性队列 (LDC) 是一个大型且高度多样化的老年人群体，每年跟踪调查 尸检，并监督从这些人获得的多个来源的数据的收集。这 队列在 ADRC 中非常独特，因为它包括来自两个国家的大量老年人 美国最大的代表性不足群体：非裔美国人（约占该群体的 25%）和西班牙裔美国人（约 25%）。 这种多样性转化为认知轨迹、阿尔茨海默病和相关疾病的异质性 痴呆症 (ADRD)、危险因素和生命历程经历以及血管危险因素的患病率 与社区人群一致，从而为研究 AD 和混合人群提供了宝贵的资源 病理学。样本在教育（0-20 岁范围）、母语、 社会经济和移民状况以及面临的逆境。主要通过社区招募， UCD ADRC 招募认知正常和轻度受损的个体来研究认知衰退和 过渡到疾病的各个阶段。这有助于识别新的可改变风险和保护措施 因素和生物标志物的开发，两者都对痴呆症的预防具有影响。所有个人在 LDC 的特征异常丰富（远远超出 UDS），包括神经影像学和 血液生物标志物、年度诊断分类、认知和心理测量的严格测量 日常功能（与用于诊断的测量分开）和生命历程的广泛收集 社会文化和行为数据。 LDC 是一个完善的队列，拥有来自活跃和活跃的大量数据 (n=425) 和不活跃病例 (n>950)，其中一些病例进行了 15 年以上的随访。所有这些数据都已集成到 UCD ADRC 数据库提供了研究人员广泛使用的易于访问的研究资源 我们中心内外。来自最不发达国家的数据为创新性的新研究成果做出了贡献 在许多领域，包括增强我们对认知老化方面的民族/种族差异的理解以及 血管疾病对大脑健康的贡献以及许多其他贡献。此外，CC还有 与流行病学研究建立双向转化关系的额外优势是 了解 ADRD 的复杂决定因素并加速开发有效的治疗方法 以及整个 ADRD 谱系的预防。