Core D: Neuropathology Core

核心 D：神经病理学核心

• 批准号: 10264291
• 负责人: Ann C. McKee
• 金额: $ 29.96万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264291
• 关键词: Address; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid beta-Protein; Argyrophilic Grain Disease; Astrocytes; Biochemical; Biological Assay; Biological Markers; Boston; Brain; Brain Concussion; Cerebral Amyloid Angiopathy; Clinic; Clinical; Collaborations; Communities; DNA; Data; Diagnosis; Diagnostic; Digital Libraries; Doctor of Philosophy; Environmental Risk Factor; Epitopes; Evaluation; Exposure to; Family member; Fostering; Foundations; Framingham Heart Study; Frontotemporal Lobar Degenerations; Funding; Goals; Image; Infrastructure; Investigation; Knowledge; Leadership; Lewy Body Disease; Long-Term Effects; Measures; Methods; Microvascular Dysfunction; Molecular Profiling; Myelin; Nerve Degeneration; Nervous System Trauma; Outcome; Pathology; Phenotype; Prion Diseases; Progressive Supranuclear Palsy; RNA; Research; Research Personnel; Research Training; Resources; Risk Factors; Role; Scientist; Slide; System; Tauopathies; Tissues; Training; Trauma; United States National Institutes of Health; Universities; Work; abeta deposition; age related; alpha synuclein; biomarker development; chronic traumatic encephalopathy; contact sports; corticobasal degeneration; cytokine; data management; digital; education research; genetic profiling; genetic risk factor; head impact; high resolution imaging; hippocampal sclerosis; improved; innovation; international center; member; military service; neuroinflammation; neuropathology; next generation; novel marker; outreach; phenotypic data; programs; protein TDP-43; recruit; skills; statistics; tau Proteins; white matter

The Boston University Alzheimer’s Disease Research Center (BU ADRC) Neuropathology Core (NC) facilitates AD/ADRD research, conducts cutting-edge multi-ADRC AD/ADRD research and provides national leadership in AD/ADRD neuropathology. We facilitate AD/ADRD research by performing state-of-the-art diagnostic neuropathological evaluation on all brain donors, sharing well-characterized CNS tissue and biospecimens with qualified investigators; providing deep neuropathological phenotyping to foster innovative collaborations; and training the next generation of AD/ADRD neuropathologists and researchers. In addition, the NC conducts cutting-edge multi-ADRC research on AD/ADRD. The BU ADRC NC’s transformational research on post-traumatic neurodegeneration has changed scientific understanding of neurotrauma as a risk factor for AD/ADRD, including chronic traumatic encephalopathy (CTE). The NC has also shown that exposure to repetitive head impacts (RHI) alters the deposition of beta amyloid, alpha-synuclein, and TDP-43. Currently, the NC is collaborating with multiple ADRCs and centers (UCSF, Mayo Clinic, Mount Sinai, MGH, UT San Antonio) to continue this ground- breaking research. In addition, the NC provides national leadership by leading two major multi- ADRC NIH-funded programs on AD/ADRD. The NC will build on this strong record of accomplishment and leadership to support innovative multi-ADRC AD/ADRD research in 3 domains that support National Alzheimer’s Project Act (NAPA) milestones for AD/ADRD research: Understanding the contribution of RHI/TBI exposure to AD/ADRD; Understanding the role of age-related and trauma-related microvascular disease and white matter degeneration to AD/ADRD; Improving the neuropathological diagnostic and nosologic criteria for frontotemporal lobar degeneration-tau (FTLD-tau). The NC also works closely with the Framingham Heart Study by directing all brain banking and neuropathological analyses. In partnership with the Concussion Legacy Foundation global brain bank initiative, the BU ADC NC is committed to advancing multi-center international research. Throughout all its aims, the NC will work with the Clinical Core and Data Management and Statistics Core to enhance clinicopathological correlation in AD/ADRD, the Biomarker Core to develop novel biomarkers for AD/ADRD, the Genetics and Molecular Profiling Core to define genetic risk factors for AD/ADRD, the Research Education Component (REC) to engage trainees in scientific investigations and build skills in AD/ADRD research and the Outreach, Recruitment and Engagement Core (ORE) to educate the greater Boston community about the value of brain donation.

波士顿大学阿尔茨海默病研究中心（BU ADRC）神经病理学核心 (NC)促进AD/ADRD研究，进行尖端的多ADRC AD/ADRD研究， 在AD/ADRD神经病理学方面提供国家领导。我们通过以下方式促进AD/ADRD研究 对所有大脑捐赠者进行最先进的神经病理学诊断评估， 由合格的研究者进行充分表征的CNS组织和生物标本;提供深入的 神经病理学表型，以促进创新合作;和培训下一个 AD/ADRD神经病理学家和研究人员的一代。此外，NC还 AD/ADRD的前沿多ADRC研究。BU ADRC NC的改造研究 关于创伤后神经变性的研究改变了对神经创伤的科学理解， AD/ADRD的风险因素，包括慢性创伤性脑病（CTE）。NC还 显示暴露于重复头部撞击（RHI）改变了β淀粉样蛋白的沉积， α-突触核蛋白和TDP-43。目前，全国委员会正在与多个发展成果中心合作， 中心（加州大学旧金山分校，马约诊所，西奈山，MGH，UT圣安东尼奥）继续这一基础- 突破性的研究此外，NC通过领导两个主要的多边机构提供国家领导， ADRC NIH资助的AD/ADRD项目。NC将建立在这一强大的记录， 成就和领导，以支持创新的多ADRC AD/ADRD研究在3 支持国家阿尔茨海默病项目法案（NAPA）AD/ADRD里程碑的领域 研究：了解RHI/TBI暴露对AD/ADRD的贡献;了解 年龄相关和创伤相关的微血管疾病和白色物质变性对 额颞叶AD/ADRD的神经病理诊断和疾病分类标准的改进 小叶变性-tau蛋白（FTLD-tau）。NC还与博爱之心密切合作 通过指导所有的大脑银行和神经病理学分析进行研究。伙伴合作下 脑震荡遗产基金会全球脑库倡议，BU ADC NC致力于 推进多中心国际研究。在其所有目标中，全国委员会将与 临床核心和数据管理和统计核心，以提高临床病理 AD/ADRD的相关性，开发AD/ADRD新生物标志物的生物标志物核心， 遗传学和分子特征分析核心定义AD/ADRD的遗传风险因素，研究 教育部分（REC），使受训者参与科学调查并培养 AD/ADRD研究和外联，招聘和参与核心（ORE）教育 关于大脑捐赠的价值