Core D: Neuropathology Core

波士顿大学阿尔茨海默病研究中心神经病理学核心 (NC)促进AD/ADRD研究，开展前沿的多ADRC AD/ADRD研究和 在AD/ADRD神经病理学领域处于全国领先地位。我们通过以下方式促进AD/ADRD研究 对所有脑捐赠者进行最先进的诊断神经病理评估，分享 具有良好特征的CNS组织和生物标本，具有合格的调查人员；提供深度 神经病理表型，以促进创新合作；并培训下一位 一代AD/ADRD神经病理学家和研究人员。此外，NC还进行 关于AD/ADRD的前沿多ADRC研究。北大ADRC数控系统的改造研究 关于创伤后神经变性的研究改变了人们对神经创伤的科学理解 AD/ADRD的危险因素，包括慢性创伤性脑病。全国委员会还 研究表明，暴露于重复头部撞击(RHI)会改变β淀粉样蛋白的沉积， α-突触核蛋白和TDP-43。目前，NC正在与多个ADRC和 中心(加州大学旧金山分校、梅奥诊所、西奈山、MGH、德克萨斯大学圣安东尼奥分校)继续这一基础- 突破性的研究。此外，全国委员会通过领导两大多党来提供全国领导 ADRC NIH资助的AD/ADRD项目。全国委员会将建立在这一强劲记录的基础上 取得成就并发挥领导作用，支持创新的多个ADRC AD/ADRD研究3 支持AD/ADRD的国家阿尔茨海默病项目法案(NAPA)里程碑的领域 研究：了解RHI/TBI暴露于AD/ADRD的贡献；了解 年龄相关和创伤相关的微血管疾病和白质变性对 改进额颞部神经病理诊断和病因学标准 肺叶变性(FTLD-tau)。全国委员会还与弗雷明翰之心密切合作 通过指导所有脑库和神经病理学分析进行研究。与 脑震荡遗产基金会全球脑库倡议，BU ADC NC致力于 推进多中心国际化研究。在其所有目标中，全国委员会将与 临床核心、数据管理和统计核心提升临床病理学水平 AD/ADRD的相关性，这是开发AD/ADRD新生物标志物的生物标志物核心， 遗传学和分子图谱核心确定AD/ADRD的遗传危险因素，研究 教育部分(REC)，让受训人员参与科学研究并培养技能 AD/ADRD研究和外联、招聘和参与核心(ORE)，以教育 更大的波士顿社区对大脑捐赠的价值。

The Boston University Alzheimer’s Disease Research Center (BU ADRC) Neuropathology Core (NC) facilitates AD/ADRD research, conducts cutting-edge multi-ADRC AD/ADRD research and provides national leadership in AD/ADRD neuropathology. We facilitate AD/ADRD research by performing state-of-the-art diagnostic neuropathological evaluation on all brain donors, sharing well-characterized CNS tissue and biospecimens with qualified investigators; providing deep neuropathological phenotyping to foster innovative collaborations; and training the next generation of AD/ADRD neuropathologists and researchers. In addition, the NC conducts cutting-edge multi-ADRC research on AD/ADRD. The BU ADRC NC’s transformational research on post-traumatic neurodegeneration has changed scientific understanding of neurotrauma as a risk factor for AD/ADRD, including chronic traumatic encephalopathy (CTE). The NC has also shown that exposure to repetitive head impacts (RHI) alters the deposition of beta amyloid, alpha-synuclein, and TDP-43. Currently, the NC is collaborating with multiple ADRCs and centers (UCSF, Mayo Clinic, Mount Sinai, MGH, UT San Antonio) to continue this ground- breaking research. In addition, the NC provides national leadership by leading two major multi- ADRC NIH-funded programs on AD/ADRD. The NC will build on this strong record of accomplishment and leadership to support innovative multi-ADRC AD/ADRD research in 3 domains that support National Alzheimer’s Project Act (NAPA) milestones for AD/ADRD research: Understanding the contribution of RHI/TBI exposure to AD/ADRD; Understanding the role of age-related and trauma-related microvascular disease and white matter degeneration to AD/ADRD; Improving the neuropathological diagnostic and nosologic criteria for frontotemporal lobar degeneration-tau (FTLD-tau). The NC also works closely with the Framingham Heart Study by directing all brain banking and neuropathological analyses. In partnership with the Concussion Legacy Foundation global brain bank initiative, the BU ADC NC is committed to advancing multi-center international research. Throughout all its aims, the NC will work with the Clinical Core and Data Management and Statistics Core to enhance clinicopathological correlation in AD/ADRD, the Biomarker Core to develop novel biomarkers for AD/ADRD, the Genetics and Molecular Profiling Core to define genetic risk factors for AD/ADRD, the Research Education Component (REC) to engage trainees in scientific investigations and build skills in AD/ADRD research and the Outreach, Recruitment and Engagement Core (ORE) to educate the greater Boston community about the value of brain donation.