Core 1: Administrative Core

核心 1：行政核心

• 批准号: 10263895
• 负责人: Maria Mori Brooks
• 金额: $ 121.92万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263895
• 关键词: Activities of Daily Living; Affect; Age; Age-Years; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Ancillary Study; Cardiac health; Cardiovascular Diseases; Characteristics; Clinical; Communication; Communities; Country; Creativeness; Data; Data Collection; Databases; Dementia; Disease; Doctor of Philosophy; Educational workshop; Elderly; Enrollment; Ensure; Epidemiology; Event; Follow-Up Studies; Fostering; Foundations; Future; Genitourinary system; Health; Health Personnel; Impaired cognition; Impairment; Incidence; Infrastructure; Institution; Institutional Review Boards; Intervention; Investigation; Joints; K-Series Research Career Programs; Laboratories; Lead; Leadership; Life; Life Experience; Link; Longevity; Longitudinal Studies; Longitudinal cohort study; Manuscripts; Measures; Menopause; Methods; Monitor; Musculoskeletal; Observational Study; Outcome; Participant; Perimenopause; Physical Function; Physiological; Prevention; Productivity; Public Health Schools; Publications; Quality of life; Reporting; Research; Research Design; Research Personnel; Research Support; Resources; Risk Factors; Role; Science; Secure; Sex Functioning; Site; Sleep disturbances; Strategic Planning; Structure; Study of Women' s Health Across the Nation; System; Testing; Translating; Translations; United States; Universities; Vascular Dementia; Visit; Woman; Women' s Health; Work; Writing; age related; base; career development; clinical practice; clinical research site; clinically relevant; cognitive function; cohort; critical period; data centers; dementia risk; design; disability; epidemiologic data; follow-up; heart function; human old age (65+); innovation; investigator training; middle age; mild cognitive impairment; modifiable risk; multi-racial; multiple chronic conditions; novel; operation; organizational structure; participant retention; participant safety; physical conditioning; physically handicapped; preservation; psychosocial; racial and ethnic; research study; socioeconomics; success; welfare

SWAN-Aging is designed to determine the extent to which midlife health and characteristics of the menopause transition (MT) affect successful aging in women, including the rate of cognitive decline and the risk of dementia and disability. Studies on aging highlight the midlife (age 40-65 years) as a critical life stage for prevention of cognitive impairment, Alzheimer’s disease, Alzheimer’s disease related dementia, physical disability and multi-morbidity in old age. This U19 proposal will extend follow-up of the Study of Women’s Health Across the Nation (SWAN), a longitudinal study initiated in 1994 to characterize the physiological and psychosocial changes that occur during the MT, into early old age (66-75 years). It will expand data collection to link midlife health characteristics and modifiable risk factors to early and rapid cognitive decline, incidence of mild cognitive impairment, cardiac health, and physical function in early old age. SWAN-Aging will leverage the existing SWAN scientific expertise and organizational structure to create three integrated Projects. Project 1 will evaluate the impact of MT characteristics and midlife health indicators on preservation of cognitive function (avoiding cognitive decline and onset of mild cognitive impairment), sleep, genitourinary and sexual function, and quality of life in early old age; Project 2 will test how the MT relates to cardiac health and cardiovascular disease (CVD) events in women in early old age and test how cardiac health relates to early markers of physical impairment, Alzheimer’s disease, and vascular dementia at a critical period in the lifespan; and Project 3 will examine the role of the MT and midlife characteristics on musculoskeletal health and physical functioning. The specific aims of Administrative Core (Core 1) are to: 1) Provide leadership, strategic planning, and organizational infrastructure for SWAN-Aging; 2) Facilitate investigator interaction, creativity, and productivity; 3) Disseminate SWAN and SWAN-Aging results and enhance translation; 4) Ensure broad use of SWAN data and support career development; and 5) Monitor and protect participant safety. Core 1 will coordinate and support research efforts across the Projects and Cores and will supply the required resources to execute study operations. Core 1 will support an Integrative Sciences Committee that will facilitate cross-cutting investigations of the interrelationships between cognitive, cardiac, and physical function, and their joint impact on activities of daily living disability. Core 1 will also lead a new Translation and Dissemination Committee in which experts in women’s health will develop methods for disseminating rigorous research results focused on the enhancement of physical health and the prevention of dementia and disability for clinical and lay communities. The Administrative Core will provide the structure required for the SWAN-Aging Projects to successfully conduct their studies, produce meaningful research results, and translate clinically relevant findings to facilitate identification of midlife prevention targets to delay or avoid mild cognitive impairment, preserve functioning, maintain independence, and optimize quality of life in early old age.

天鹅衰老旨在确定更年期过渡（MT）的中年健康和特征的程度影响女性的成功衰老，包括认知能力下降的速度以及痴呆症和残疾的风险。衰老的研究突出了中年（40-65岁），这是预防认知障碍，阿尔茨海默氏病，阿尔茨海默氏病与痴呆症相关的关键生命阶段，老年人的身体残疾和多种疾病。 U19提案将对全国妇女健康的研究（天鹅）进行随访，这是一项纵向研究，于1994年启动，旨在将MT期间的身体和心理社会变化描述为年纪幼年（66 - 75年）。它将扩大数据收集，以将中年的健康特征和可修改的危险因素与早期认知障碍的早期和快速认知能力联系起来，在早期的早期认知障碍，心脏健康和身体机能。天鹅衰老将利用现有的天鹅科学专业知识和组织结构来创建三个集成项目。项目1将评估MT特征和中年健康指标对保存认知功能（避免认知能力下降和轻度认知障碍的发作）的影响，睡眠，刚毒和性功能以及老年时代的生活质量；项目2将测试MT在老年妇女中与心脏健康和心血管疾病（CVD）事件的关系，并测试心脏健康与生理障碍，阿尔茨海默氏病和血管性痴呆的早期标志与生命周期的关键时期有关；项目3将研究MT和中年特征在肌肉骨骼健康和身体机能方面的作用。行政核心的具体目的（核心1）是：1）为天鹅提供领导，战略计划和组织基础设施； 2）促进研究者的互动，创造力和生产力； 3）传播天鹅和天鹅的结果并增强翻译； 4）确保广泛使用天鹅数据并支持职业发展； 5）监视和保护参与安全。 Core 1将协调和支持整个项目和核心的研究工作，并将提供所需的资源来执行研究操作。 Core 1将支持一个综合科学委员会，该委员会将支持对认知，心脏和身体机能之间的相互关系的跨切割调查，以及它们对日常生活残疾活动的共同影响。 Core 1还将领导一个新的翻译和传播委员会，在该委员会中，妇女健康方面的专家将开发用于传播严格的研究结果的方法，该研究的重点是增强身体健康，预防痴呆症和临床和外行社区的残疾。行政核心将为SwanGing项目提供成功进行研究，产生有意义的研究结果并翻译临床相关的发现所需的结构，以促进预防中年预防目标，以延迟或避免轻度认知障碍，保持功能，维持独立性，维持独立性并优化早期的生活质量。