Core 1: Administrative Core

核心 1：行政核心

• 批准号: 10263895
• 负责人: Maria Mori Brooks
• 金额: $ 121.92万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263895
• 关键词: Activities of Daily Living; Affect; Age; Age-Years; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Ancillary Study; Cardiac health; Cardiovascular Diseases; Characteristics; Clinical; Communication; Communities; Country; Creativeness; Data; Data Collection; Databases; Dementia; Disease; Doctor of Philosophy; Educational workshop; Elderly; Enrollment; Ensure; Epidemiology; Event; Follow-Up Studies; Fostering; Foundations; Future; Genitourinary system; Health; Health Personnel; Impaired cognition; Impairment; Incidence; Infrastructure; Institution; Institutional Review Boards; Intervention; Investigation; Joints; K-Series Research Career Programs; Laboratories; Lead; Leadership; Life; Life Experience; Link; Longevity; Longitudinal Studies; Longitudinal cohort study; Manuscripts; Measures; Menopause; Methods; Monitor; Musculoskeletal; Observational Study; Outcome; Participant; Perimenopause; Physical Function; Physiological; Prevention; Productivity; Public Health Schools; Publications; Quality of life; Reporting; Research; Research Design; Research Personnel; Research Support; Resources; Risk Factors; Role; Science; Secure; Sex Functioning; Site; Sleep disturbances; Strategic Planning; Structure; Study of Women' s Health Across the Nation; System; Testing; Translating; Translations; United States; Universities; Vascular Dementia; Visit; Woman; Women' s Health; Work; Writing; age related; base; career development; clinical practice; clinical research site; clinically relevant; cognitive function; cohort; critical period; data centers; dementia risk; design; disability; epidemiologic data; follow-up; heart function; human old age (65+); innovation; investigator training; middle age; mild cognitive impairment; modifiable risk; multi-racial; multiple chronic conditions; novel; operation; organizational structure; participant retention; participant safety; physical conditioning; physically handicapped; preservation; psychosocial; racial and ethnic; research study; socioeconomics; success; welfare

SWAN-Aging is designed to determine the extent to which midlife health and characteristics of the menopause transition (MT) affect successful aging in women, including the rate of cognitive decline and the risk of dementia and disability. Studies on aging highlight the midlife (age 40-65 years) as a critical life stage for prevention of cognitive impairment, Alzheimer’s disease, Alzheimer’s disease related dementia, physical disability and multi-morbidity in old age. This U19 proposal will extend follow-up of the Study of Women’s Health Across the Nation (SWAN), a longitudinal study initiated in 1994 to characterize the physiological and psychosocial changes that occur during the MT, into early old age (66-75 years). It will expand data collection to link midlife health characteristics and modifiable risk factors to early and rapid cognitive decline, incidence of mild cognitive impairment, cardiac health, and physical function in early old age. SWAN-Aging will leverage the existing SWAN scientific expertise and organizational structure to create three integrated Projects. Project 1 will evaluate the impact of MT characteristics and midlife health indicators on preservation of cognitive function (avoiding cognitive decline and onset of mild cognitive impairment), sleep, genitourinary and sexual function, and quality of life in early old age; Project 2 will test how the MT relates to cardiac health and cardiovascular disease (CVD) events in women in early old age and test how cardiac health relates to early markers of physical impairment, Alzheimer’s disease, and vascular dementia at a critical period in the lifespan; and Project 3 will examine the role of the MT and midlife characteristics on musculoskeletal health and physical functioning. The specific aims of Administrative Core (Core 1) are to: 1) Provide leadership, strategic planning, and organizational infrastructure for SWAN-Aging; 2) Facilitate investigator interaction, creativity, and productivity; 3) Disseminate SWAN and SWAN-Aging results and enhance translation; 4) Ensure broad use of SWAN data and support career development; and 5) Monitor and protect participant safety. Core 1 will coordinate and support research efforts across the Projects and Cores and will supply the required resources to execute study operations. Core 1 will support an Integrative Sciences Committee that will facilitate cross-cutting investigations of the interrelationships between cognitive, cardiac, and physical function, and their joint impact on activities of daily living disability. Core 1 will also lead a new Translation and Dissemination Committee in which experts in women’s health will develop methods for disseminating rigorous research results focused on the enhancement of physical health and the prevention of dementia and disability for clinical and lay communities. The Administrative Core will provide the structure required for the SWAN-Aging Projects to successfully conduct their studies, produce meaningful research results, and translate clinically relevant findings to facilitate identification of midlife prevention targets to delay or avoid mild cognitive impairment, preserve functioning, maintain independence, and optimize quality of life in early old age.

SWAN-Aging旨在确定中年健康和更年期过渡（MT）特征对女性成功衰老的影响程度，包括认知能力下降的速度以及痴呆和残疾的风险。关于衰老的研究强调，中年（40-65岁）是预防老年认知功能障碍、阿尔茨海默病、阿尔茨海默病相关痴呆、身体残疾和多种疾病的关键生命阶段。这项U19提案将把全国妇女健康研究（SWAN）的后续工作延长至老年早期（66-75岁）。SWAN是1994年发起的一项纵向研究，旨在描述更年期期间发生的生理和社会心理变化。它将扩大数据收集，将中年健康特征和可改变的风险因素与早期和快速的认知能力下降、轻度认知障碍的发生率、心脏健康和老年早期的身体功能联系起来。SWAN- aging将利用现有的SWAN科学专业知识和组织结构来创建三个综合项目。项目1将评估MT特征和中年健康指标对老年早期认知功能（避免认知衰退和轻度认知障碍的发生）、睡眠、泌尿生殖系统和性功能以及生活质量的影响；项目2将测试MT如何与早期老年妇女的心脏健康和心血管疾病（CVD）事件相关，并测试心脏健康如何与生命中关键时期的身体损伤、阿尔茨海默病和血管性痴呆的早期标志物相关；项目3将研究MT和中年特征对肌肉骨骼健康和身体功能的作用。行政核心（核心1）的具体目标是：1)为SWAN-Aging提供领导、战略规划和组织基础设施；2)促进研究者的互动、创造力和生产力；3)传播SWAN和SWAN- aging结果，加强翻译；4)确保SWAN数据的广泛使用，支持职业发展；5)监督和保护参与者的安全。核心1将协调和支持跨项目和核心的研究工作，并将提供执行研究操作所需的资源。核心1将支持一个综合科学委员会，该委员会将促进认知、心脏和身体功能之间相互关系的交叉研究，以及它们对日常生活残疾活动的共同影响。核心1还将领导一个新的翻译和传播委员会，在该委员会中，妇女健康方面的专家将制定方法，传播侧重于增强临床和非专业社区的身体健康和预防痴呆和残疾的严谨研究成果。行政核心将为SWAN-Aging项目提供所需的结构，以成功开展研究，产生有意义的研究结果，并将临床相关发现转化为促进确定中年预防目标，以延迟或避免轻度认知障碍，保持功能，保持独立性，并优化老年早期的生活质量。