Urotensin II and renal insufficiency in growth-restricted infants.

尾加压素 II 和生长受限婴儿的肾功能不全。

基本信息

项目摘要

Intrauterine growth restriction (IUGR) is associated with perinatal organ injury and the risk of developing cardiovascular, renal, and metabolic disorders in later life. Hence, elucidation of the mechanisms that cause early and progressive organ derangement in growth-restricted newborns is necessary to reduce infant and adult morbidity and mortality. Urotensin II (UII), a potent vasoactive peptide modulates renal function, and its levels are increased in infants with heart and kidney disease. Although its physiological and pathophysiological mechanisms are unresolved, recent evidence suggests that the UII system can promote neurotransmission, thereby altering organ function. Here, we propose a new concept that an increase in UII activity contributes to renal insufficiency in growth-restricted newborns. UII stimulates peripheral sympathoexcitation via Ca2+-dependent tyrosine hydroxylase phosphorylation, catecholamine biosynthesis, and neurotransmission. Sympathetic outflow elicited by UII triggers kidney injury in the neonates. These concepts will be investigated in newborn pigs and a preclinical porcine model of naturally-occurring human asymmetric IUGR. Using innovative procedures for translational research, we will study renal function in small-for-gestational-age neonatal pigs and elucidate the function and regulation of the UII system and the contribution of its components to 1) alterations in neonatal renal hemodynamics and 2) renal insufficiency in growth-restricted infants. We anticipate that our proposed studies will have a significant impact on understanding the pathophysiology of the immature kidney.
宫内生长限制(IUGR)与围产期器官损伤和发展的风险有关

项目成果

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Adebowale Adebiyi其他文献

Adebowale Adebiyi的其他文献

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{{ truncateString('Adebowale Adebiyi', 18)}}的其他基金

Control of microvascular function by ion channels
离子通道控制微血管功能
  • 批准号:
    10591881
  • 财政年份:
    2020
  • 资助金额:
    $ 55.59万
  • 项目类别:
Control of microvascular function by ion channels
离子通道控制微血管功能
  • 批准号:
    10594479
  • 财政年份:
    2020
  • 资助金额:
    $ 55.59万
  • 项目类别:
Vascular ion channels and microcirculation in neonatal urinary tract obstruction
新生儿尿路梗阻的血管离子通道与微循环
  • 批准号:
    10341119
  • 财政年份:
    2020
  • 资助金额:
    $ 55.59万
  • 项目类别:
Control of microvascular function by ion channels
离子通道控制微血管功能
  • 批准号:
    10392350
  • 财政年份:
    2020
  • 资助金额:
    $ 55.59万
  • 项目类别:
Urotensin II and renal insufficiency in growth-restricted infants.
尾加压素 II 和生长受限婴儿的肾功能不全。
  • 批准号:
    10469433
  • 财政年份:
    2020
  • 资助金额:
    $ 55.59万
  • 项目类别:
Vascular ion channels and microcirculation in neonatal urinary tract obstruction
新生儿尿路梗阻的血管离子通道与微循环
  • 批准号:
    9884233
  • 财政年份:
    2020
  • 资助金额:
    $ 55.59万
  • 项目类别:
Vascular ion channels and microcirculation in neonatal urinary tract obstruction
新生儿尿路梗阻的血管离子通道与微循环
  • 批准号:
    10565955
  • 财政年份:
    2020
  • 资助金额:
    $ 55.59万
  • 项目类别:
Control of microvascular function by ion channels
离子通道控制微血管功能
  • 批准号:
    10201230
  • 财政年份:
    2020
  • 资助金额:
    $ 55.59万
  • 项目类别:
Control of microvascular function by ion channels
离子通道控制微血管功能
  • 批准号:
    10808238
  • 财政年份:
    2020
  • 资助金额:
    $ 55.59万
  • 项目类别:
Regulation of neonatal renal hemodynamics
新生儿肾脏血流动力学的调节
  • 批准号:
    9303346
  • 财政年份:
    2014
  • 资助金额:
    $ 55.59万
  • 项目类别:

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