UVA molecular electron microscopy core for the Mid-Atlantic region
大西洋中部地区的 UVA 分子电子显微镜核心
基本信息
- 批准号:10263352
- 负责人:
- 金额:$ 18.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-01 至 2022-07-31
- 项目状态:已结题
- 来源:
- 关键词:Biological SciencesCollaborationsCommunicationCore FacilityCryoelectron MicroscopyDataData CollectionElectron MicroscopeElectron MicroscopyElectronsFacultyFloorFosteringFreezingFundingFutureGrantGrowthImage AnalysisInfrastructureLaboratoriesLightingMacromolecular ComplexesMid-Atlantic RegionMolecularMolecular MedicineMontserratProductivityResearchResolutionRoboticsSchoolsScientistStudentsTimeTitanTranslational ResearchUnited States National Institutes of HealthUniversitiesVirginiaVisionVisitdesigndetectorexperienceimprovedinstrumentationlensmedical schoolsmemberstructural biologytime usetransmission process
项目摘要
Abstract
The Molecular Electron Microscopy Core (MEMC) facility at the University of Virginia (UVa) is comprised of
three transmission electron microscopes. An FEI 120 kV Spirit is housed on the second floor of the Snyder
Translational Research Building at Fontaine Research Park. An FEI 200 kV F20 and a 300 kV Titan Krios are
located in a specially designed suite in the underground Life Sciences Annex (LiSA) adjacent and connected to
the Snyder Building. Anticipating future growth in high-resolution cryoEM research, the suite was designed to
accommodate two Titan Krios electron microscopes. The Titan Krios has an autoloader that robotically
manipulates up to 12 frozen grids inserted at one time, uses constant current lenses for greater stability, is
equipped with an XFEG for improved illumination and a Falcon II direct electron detector. In 2009, the abstract
of our G20 grant that supported the build-out of the LiSA suite stated, “The MEMC facility will (1) enhance the
quality of research at UVa, (2) increase scientific productivity, (3) foster communication, interactions and
collaboration amongst scientists, (4) boost the ability of UVa to attract and maintain premier faculty and
students, and (5) strengthen the competitiveness of our faculty for funding. The MEMC facility will not only be
available to School of Medicine faculty members but also to other scientists in other schools and departments
at UVa. This will be a unique Core laboratory at UVa, and we envision that scientists throughout Virginia and
the surrounding states will visit UVa to take advantage of such a cutting-edge laboratory for performing
molecular resolution electron microscopy.” We have a strong spirit of collegiality and collaboration at UVa and
welcome the opportunity to share the MEMC facility within UVa and beyond. We believe that our vision of the
MEMC facility as a state-of-the-art cryoEM center for scientists in the mid-Atlantic region has already been
realized. Over the last two years, 23 labs at UVa and 12 external labs have collected data using the MEMC.
14 labs have collected data using the Titan Krios. Half of the available time will be devoted to Consortium PIs,
who have substantial experience in cryoEM and image analysis: Drs. Jenny Hinshaw (NIH), Deborah Kelly
(Virginia Tech), Melanie Ohi (Vanderbilt), Montserrat Samso (VCU), and Peijun Zhang (Pitt). As the primary
internal UVa users of the MEMC, Drs. Yeager and Egelman have more than 5 decades of experience. As
Director of the Core, Dr. Kelly Dryden interacts closely with all users. The U24 grant, combined with
$300K/year provided by the UVa School of Medicine, would make the MEMC financially sustainable.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Vitold Galkin其他文献
Vitold Galkin的其他文献
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{{ truncateString('Vitold Galkin', 18)}}的其他基金
Mechanisms of Thin Filament Regulation by Myosin Binding Protein-C
肌球蛋白结合蛋白-C 调节细丝的机制
- 批准号:
10306335 - 财政年份:2018
- 资助金额:
$ 18.99万 - 项目类别:
REGULATION OF THE ACTIN FILAMENT POINTED END DYNAMICS IN HEALTH AND DISEASE
健康和疾病中肌动蛋白丝尖头动力学的调节
- 批准号:
10810153 - 财政年份:2017
- 资助金额:
$ 18.99万 - 项目类别:
REGULATION OF THE ACTIN FILAMENT POINTED END DYNAMICS IN HEALTH AND DISEASE
健康和疾病中肌动蛋白丝尖头动力学的调节
- 批准号:
10687109 - 财政年份:2017
- 资助金额:
$ 18.99万 - 项目类别:
UVA molecular electron microscopy core for the Mid-Atlantic region
大西洋中部地区的 UVA 分子电子显微镜核心
- 批准号:
10023265 - 财政年份:2017
- 资助金额:
$ 18.99万 - 项目类别:
UVA molecular electron microscopy core for the Mid-Atlantic region
大西洋中部地区的 UVA 分子电子显微镜核心
- 批准号:
9548722 - 财政年份:2017
- 资助金额:
$ 18.99万 - 项目类别:
REGULATION OF THE ACTIN FILAMENT POINTED END DYNAMICS IN HEALTH AND DISEASE
健康和疾病中肌动蛋白丝尖头动力学的调节
- 批准号:
10296898 - 财政年份:2017
- 资助金额:
$ 18.99万 - 项目类别:
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