Addressing Hazardous and Harmful Alcohol use Through an Adapted CBT Sleep Intervention

通过适当的 CBT 睡眠干预措施解决危险和有害的酒精使用问题

• 批准号: 10592944
• 负责人: Wilfred R Pigeon
• 金额: $ 22.14万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10592944
• 关键词: Address; Adult; Aftercare; Alcohol abuse; Alcohol consumption; Alcohols; Award; Back; Behavioral; Bypass; Clinical; Cognitive Therapy; Communities; Data; Development; Diagnostic; Education; Enrollment; Feasibility Studies; Feeling suicidal; Future; Glean; Individual; Intervention; Manuals; Measurement; Measures; Mental Depression; Mental Health; Methods; Moods; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Outcome; Outcome Measure; Participant; Patient Recruitments; Patient Self-Report; Patients; Pattern; Phase; Pilot Projects; Population; Post-Traumatic Stress Disorders; Preparation; Prevention trial; Procedures; Prognosis; Public Health; Recovery; Research; Research Design; Risk Factors; Sampling; Self Medication; Severities; Sleep; Sleep Disorders; Sleeplessness; Societies; Substance Use Disorder; Telephone; Testing; alcohol abuse therapy; alcohol effect; alcohol misuse; alcohol use disorder; associated symptom; brief intervention; burden of illness; cognitive testing; comorbidity; comparison intervention; cost; depressive symptoms; design; diagnostic criteria; drinking; experience; follow up assessment; follow-up; improved; improvement on sleep; indexing; intervention effect; medical specialties; modifiable risk; mortality; open label; physical conditioning; programs; prospective; randomized trial; recruit; response; social stigma; substance abuse prevention; suicidal behavior; symptomatic improvement; telephone delivery; therapy design; therapy development; timeline

Project Summary/Abstract Drinking problems and sleep problems each cause significant loss at individual and societal levels. Insomnia in particular is highly prevalent in patients with alcohol use disorder, is prospectively associated with the development of alcohol use disorder and contributes to poorer recovery prognosis following alcohol treatments. Insomnia, therefore, represents a modifiable risk factor for negative outcomes associated with alcohol use along the full continuum of alcohol use problems. Accordingly, the project proposes to improve sleep with an insomnia intervention tailored to individuals who meet widely accepted definitions for hazardous alcohol use as well as diagnostic criteria for insomnia disorder. This is a treatment development study that will adapt cognitive behavioral therapy for insomnia for adults engaged in hazardous use of alcohol. We propose an iterative approach to development, refinement, and preliminary examination of the utility of a telephone-delivered, 4-session version of cognitive behavioral therapy for insomnia adapted to hazardous alcohol users. The project will begin with a small, open label pilot to develop and refine procedures for administering the intervention. Then, we will conduct a small, randomized trial comparing the intervention to a sleep and alcohol education control condition. As this is a treatment development award, we will assess a number of intervention and study design feasibility domains in preparation for designing a larger study. We will also assess the effects of the intervention on alcohol use, sleep and mood by measuring these outcomes at baseline, post-treatment, and at 3- and 6-month follow up assessments. In sum, this proposal is the first step in a program of research that intends to use sleep as a lever to alter the course of hazardous alcohol use. Here, the first step is to adapt an already successful insomnia intervention to a unique population and conduct a preliminary test of that interventions’ acceptability to patients, fidelity by therapists, and effects on drinking, sleep and mood. If study results are promising, we will use these data and information gleaned about the study methods to pursue the next phase of research: designing and conducting a definitive study to test our insomnia intervention’s capacity to decrease alcohol use and modify the course of hazardous alcohol use.

项目总结/摘要 饮酒问题和睡眠问题都在个人和社会层面造成重大损失。失眠 特别是在酒精使用障碍患者中非常普遍， 酒精使用障碍的发展，并有助于酒精治疗后恢复预后较差。 因此，饮酒是与饮酒相关的负面结果的一个可改变的风险因素 沿着整个连续的酒精使用问题。 因此，该项目建议通过针对以下人群的失眠干预来改善睡眠： 符合广泛接受的危险酒精使用的定义以及失眠症的诊断标准。 这是一项治疗开发研究，将适应成人失眠的认知行为疗法 从事危险使用酒精。我们提出了一个迭代的方法来开发，细化， 电话传递的认知行为治疗的4个疗程版本的效用的初步检验 治疗失眠症的药物 该项目将开始一个小的，开放标签的试点，以开发和完善程序，管理 干预然后，我们将进行一项小型随机试验，将干预措施与睡眠和酒精进行比较。 教育控制条件。由于这是一个治疗发展奖，我们将评估一些干预措施， 研究设计可行性领域，为设计更大规模的研究做准备。我们还将评估 通过测量基线、治疗后、 以及3个月和6个月随访评估时。 总之，这项建议是一项研究计划的第一步，该计划旨在利用睡眠作为杠杆来改变睡眠。 危险的酒精使用。在这里，第一步是调整已经成功的失眠干预， 一个独特的人群，并进行初步测试，干预措施的可接受性，病人的保真度， 以及对饮酒、睡眠和情绪的影响。如果研究结果有希望，我们将使用这些数据， 收集有关研究方法的信息，以进行下一阶段的研究：设计和实施 一项明确的研究，以测试我们的失眠干预的能力，以减少酒精的使用和修改的过程中， 危险的酒精使用