BLRD Merit Review Research Career Scientist Award

BLRD 优异评审研究职业科学家奖

• 批准号: 10594022
• 负责人: Shyam S Mohapatra
• 金额: --
• 依托单位: JAMES A. HALEY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2029-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594022
• 关键词: 2019-nCoV; 3-Dimensional; Acceleration; Affect; American; Anti-Inflammatory Agents; Artificial Intelligence; Asthma; Award; Biological Assay; Biology; Biopsy; Birds; CCL20 gene; COVID-19; Cell Therapy; Cells; Clinical; Clinical Trials; Collaborations; Data; Development; Diagnostic; Disease; Education; Educational process of instructing; Elderly; Endowment; Extramural Activities; Florida; Formulation; Funding; Future; General Population; Goals; Health; Healthcare; Hospitals; Hypersensitivity; Image Enhancement; Immunocompetent; Immunology; In Vitro; Incidence; Individual; Industry Collaboration; Inflammation; Inflammatory; International; Investments; Lead; Legal patent; Liposomes; Malignant neoplasm of brain; Malignant neoplasm of lung; Medicine; Mesenchymal Stem Cells; Methods; Modeling; Mus; Nanofiber Scaffold; Nature; Nerve Regeneration; Nursing Faculty; Oligosaccharides; Oncolytic; Peptides; Phospholipids; Pneumonia; Property; Prophylactic treatment; Publications; Reporting; Research; Research Activity; Research Personnel; Research Support; Respiratory Syncytial Virus Infections; Respiratory syncytial virus; SARS-CoV-2 antiviral; Safety; Scientist; Seminal; Small Interfering RNA; System; Technology; Testing; Therapeutic; Translations; Traumatic Brain Injury; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Veterans; Viral; Viral Respiratory Tract Infection; Virus Diseases; Work; bench to bedside; career; chest computed tomography; clinical diagnosis; clinical diagnostics; clinical training; combinatorial; drug efficacy; efficacy testing; experience; graduate student; human disease; improved; in vivo; indexing; influenza infection; inhibitor; innovation; mouse model; nano; nanoformulation; nanomedicine; nanomicelles; nanoscale; nanosystems; nanotherapeutic; novel; novel diagnostics; novel therapeutics; novel virus; pandemic disease; particle; personalized cancer therapy; prevent; professor; prophylactic; respiratory infection virus; stem cell therapy; translational medicine

This proposal seeks to renew Research Career Scientist Award held by Dr. Shyam S Mohapatra, at the James A. Haley VA Hospital in Tampa, Florida since 2007. He is a Distinguished Health Professor and the Director of the Division of Translational Medicine- Center for Research and Education in Nanobioengineering at the VA-affiliated academic center- the University of South Florida. With ~235 publications, 40 patents, an h-index of 53 and an i-index of 161, he is recognized nationally and internationally for his contributions to the field of nanoscale biomedical diagnostics and therapeutics in relation to viral infections, traumatic brain injury (TBI) and cancers. He has received substantial extramural research support including awards from the NIH, DOA, ONR, Department of Veterans’ Affairs and Florida Department of Health. He is the recipient of several international/national awards and recognitions. Dr. Mohapatra has been a research investigator at the VA Hospital (Medicine) since 1996 and has been continuously funded with the Merit Review Award focused on respiratory syncytial virus (RSV) infection since 1999. Current and ongoing research activities to be supported by this RCS Award are as follows. Project #1. a) Develop new prophylactic, or therapeutic approaches involving broad antiviral and anti-inflammatory compounds formulated using novel nanoscale technologies, which are effective against COVID-19 and other respiratory viral infections. The currently proposed Merit Review project aims to develop a simple, smart and translatable nanoscale system that combines novel targets for antiviral- and replication and inflammation inhibitors. He currently leads two additional projects, as a multi-PI. This proposal aims to characterize novel virus-neutralizing particles that may serve as prophylaxis and/or therapy. b) Also, based on his recent experience in artificial intelligence (AI)-enhanced imaging, and preliminary data with COVID-19, he was funded by CSRD to examine the potential to clinically diagnose and prognose COVID 19 by AI-aided chest CT. Project #2. Investigate and test a novel targeted oncolytic viro-cell therapy (OVT) for lung cancer using the mesenchymal stem cell (MSCs) infected by RSV, which is harmless for immunocompetent individuals. Thus, it is planned to use a 3D multicell tumoroid and biopsy-derived cultures in vitro and mouse model of lung cancer in vivo to evaluate the safety and efficacy of OVT. The project to data has attracted industry collaboration, which might lead to clinical trials. Project #3. Investigate the potential of a novel combinatorial therapeutic approach in a mouse CCI model of moderate TBI that includes (i) a treatment to reduce inflammation (local and systemic) using a nano-formulated siRNA against a recently discovered target, CCL20, and (ii) a second treatment to promote neuroregeneration by MSC therapy. VA Impact: These highly innovative applications of nanomedicine approaches taken together are expected to lead to high-impact clinical diagnostics and therapies for Veterans and other Americans in need. Veterans have been proportionately affected by the pandemic, and are increasingly affected by the incidence of lung cancers and TBI compared to the general population. The development of these effective nanotherapeutics will greatly improve the quality of Veteran’s healthcare.

该提案旨在更新由Shyam S Mohapatra博士举办的研究职业科学家奖，