Nanomedicine Research Center Core (NRCC)

纳米医学核心研究中心 (NRCC)

• 批准号: 7936169
• 负责人: Shyam S Mohapatra
• 金额: $ 66.45万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7936169
• 关键词: 3-Dimensional; Affect; Area; Arts; Basic Science; Blood; Cells; Clinic; Collaborations; Discipline of Nursing; Doctor of Philosophy; Engineering; Equipment and Supplies; Faculty; Florida; Fostering; Funding; Goals; Heart; Hematological Disease; Hospitals; Human Resources; Immune; Individual; Industry; Interdisciplinary Study; Knowledge; Laboratories; Life; Lung; Lung diseases; Medical; Medicine; Mission; Molecular; Nanotechnology; Occupations; Positioning Attribute; Postdoctoral Fellow; Public Health; Qualifying; Research; Research Proposals; Resources; Respiratory System; Science; Scientist; Stem cells; Technology; Tissue Engineering; Training; Translational Research; Translations; Universities; Virus Diseases; Wages; Washington; Work; catalyst; college; graduate student; innovation; instructor; member; multidisciplinary; nano; nanomedicine; therapeutic target

DESCRIPTION (provided by applicant): This proposal seeks support for new faculty recruitment to enhance research resources for the Nanomedicine Research Center (NRC) at the University of South Florida College of Medicine, whose mission is to serve as a catalyst for advancing the basic and translational aspects nanomedicine for Heart, Lung and Blood disorders. The NRC goals are to: (i) develop innovative and integrative nano- and cell-technologies, (ii) nurture and foster the transition of these advanced technologies from the laboratory to the clinic, (iii) foster university-industry and Florida-wide collaborations in nanomedicine, tissue engineering and cell technologies. The NRC members (about 18) include faculty from the colleges of Arts and Sciences, Engineering, Nursing Medicine and Public Health. The NRC seeks to create a multidisciplinary team of biologists, engineers, scientists and clinicians, working in a coordinated and focused effort, to develop integrated technology to accelerate the translation of molecular and cellular knowledge into nanotechnology applications for medical and cell technologies. The NRC is located at the College of Medicine and has satellite laboratories at the VA Hospital and Interdisciplinary Research Building. The Center currently has 6 core faculty and 12 adjunct faculty and several support staff, postdoctoral fellows and graduate students. The NRC has identified two areas of research for enhancement in order of importance: (i) immune cell-targeted therapeutics for lung diseases and (ii) stem cell-blood differentiation on 3-D nanomatrices. The NRC has identified Mary Markiewicz, PhD, Instructor at Washington Univ., St Louis as a potential candidate for tenure-track faculty at the NRC. The College of Medicine has made a commitment for this position with salary and start-up funding for support personnel, equipment and supplies following the completion of P-30 support. Dr. Mary Markiwicz's basic research on NKG2D as a potential immunomodulatory system for respiratory viral infections pursued at the NRC is excellent and is expected to enhance the NRC's nanomedicine application in basic and translational research. This support is not only expected to provide jobs for 4 highly trained individuals, but will significantly affect their lives and contributions to nanomedicine research. This proposal seeks support for new faculty recruitment to enhance research resources for the Nanomedicine Research Center (NRC) at the University of South Florida College of Medicine, whose mission is to serve as a catalyst for advancing the basic and translational aspects nanomedicine for heart lung and blood disorders. This support will permit creation of four jobs to highly qualified individuals.

描述（由申请人提供）：本提案旨在为南佛罗里达大学医学院纳米医学研究中心（NRC）招聘新的教师提供支持，以增强其研究资源，该中心的使命是促进心脏、肺和血液疾病纳米医学的基础和转化方面的发展。NRC的目标是：(1)发展创新和整合的纳米和细胞技术；(2)培育和促进这些先进技术从实验室到临床的转变；(3)促进大学-工业和佛罗里达范围内纳米医学、组织工程和细胞技术的合作。NRC成员（约18人）包括文理学院、工程学院、护理医学学院和公共卫生学院的教员。NRC寻求建立一个由生物学家、工程师、科学家和临床医生组成的多学科团队，以协调和集中的努力开发综合技术，以加速将分子和细胞知识转化为用于医疗和细胞技术的纳米技术应用。NRC位于医学院，在VA医院和跨学科研究大楼设有卫星实验室。中心现有核心教师6人，兼职教师12人，支持人员、博士后和研究生数人。NRC已经确定了两个需要加强的研究领域（按重要性排序）：(i)针对肺部疾病的免疫细胞靶向治疗和（ii） 3d纳米基质上的干细胞-血液分化。美国核研究委员会已确定圣路易斯华盛顿大学讲师玛丽·马基维茨博士为核研究委员会终身教职的潜在候选人。医学院已承诺在P-30支助完成后为这一职位提供薪金和支助人员、设备和用品的启动经费。Mary Markiwicz博士在NRC进行的关于NKG2D作为呼吸道病毒感染潜在免疫调节系统的基础研究非常出色，有望增强NRC在基础和转化研究中的纳米医学应用。这种支持不仅有望为4名训练有素的个人提供就业机会，而且将显著影响他们的生活和对纳米医学研究的贡献。

项目成果

Initial observations of cell-mediated drug delivery to the deep lung.

• DOI: 10.3727/096368910x536491
• 发表时间: 2011
• 期刊: Cell transplantation
• 影响因子: 3.3
• 作者: Kumar A;Glaum M;El-Badri N;Mohapatra S;Haller E;Park S;Patrick L;Nattkemper L;Vo D;Cameron DF
• 通讯作者: Cameron DF

Transverse susceptibility as a biosensor for detection of Au-Fe₃O₄ nanoparticle-embedded human embryonic kidney cells.

• DOI: 10.3390/s130708490
• 发表时间: 2013-07-03
• 期刊: Sensors (Basel, Switzerland)
• 作者: Huls NF;Phan MH;Kumar A;Mohapatra S;Mohapatra S;Mukherjee P;Srikanth H
• 通讯作者: Srikanth H

CD4(+) T cells suppress immune response to cancer: novel targets for antitumor efforts.

CD4(+) T 细胞抑制对癌症的免疫反应：抗肿瘤工作的新目标。

• DOI: 10.1586/eci.12.29
• 发表时间: 2012
• 期刊: Expert review of clinical immunology
• 影响因子: 4.4
• 作者: Nelson,Allison;Nair,Sajitha;Nagaraj,Srinivas
• 通讯作者: Nagaraj,Srinivas

Curcumin prevents human dendritic cell response to immune stimulants.

• DOI: 10.1016/j.bbrc.2008.07.051
• 发表时间: 2008-09-26
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Shirley, Shawna A.;Montpeti, Alison J.;Lockey, R. F.;Mohapatra, Shyam S.
• 通讯作者: Mohapatra, Shyam S.

Phospholipid micelle encapsulated gadolinium oxide nanoparticles for imaging and gene delivery.

• DOI: 10.1039/c2ra22293k
• 发表时间: 2013-02-28
• 期刊: RSC advances
• 影响因子: 3.9
• 作者: Dixit S;Das M;Alwarappan S;Goicochea NL;Howell M;Mohapatra S;Mohapatra S
• 通讯作者: Mohapatra S