BioSystems Networks and Translational Research - Insights into Inflammation (BioSNTR-II)

BioSystems 网络和转化研究 - 炎症洞察 (BioSNTR-II)

• 批准号: 10593066
• 负责人: Adam David Hoppe
• 金额: $ 218.46万
• 依托单位: SOUTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-20 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593066
• 关键词: Acceleration; Animals; Area; Bioinformatics; Biological Sciences; Biomedical Research; Biotechnology; CRISPR imaging; Cell Communication; Cell Death; Cell physiology; Cells; Center for Translational Science Activities; Centers of Research Excellence; Cilia; Clinic; Clustered Regularly Interspaced Short Palindromic Repeats; Communication; Cytokine Signaling; Development; Disease; Education; Environment; Evaluation; Event; Faculty; Fostering; Funding; Genes; Genetic Transcription; Genomics; Goals; Grant; Growth; Health; Human; Inflammation; Inflammatory; Inflammatory Response; Investments; Knowledge; Labor Forces; Lymphangiogenesis; Lymphatic; Macrophage; Macrophage Cell Biology; Mentors; Microscopy; Mission; Molecular; Optics; Pathway Analysis; Pathway interactions; Performance; Personnel Management; Pilot Projects; Plants; Private Sector; Process; Program Research Project Grants; Proteins; Proteomics; Public Health; Records; Regulation; Research; Research Personnel; Research Project Grants; Resolution; Resources; Role; Senior Scientist; Signal Transduction; South Dakota; TNF gene; Technology; Technology Transfer; Tissues; Training Support; Translational Research; Translations; Ubiquitin; United States National Institutes of Health; Universities; University adminstration; Work; career; cohort; experience; formative assessment; immune cell infiltrate; improved; innovation; insight; instrumentation; interdisciplinary approach; medical schools; model development; next generation sequencing; programs; research and development; senior faculty; success; synergism; tenure track; transcriptome; transcriptome sequencing; transcriptomics

PROJECT SUMMARY – OVERALL The goal of this proposal is a coordinated, synergized, and integrated COBRE research program, called the “BioSystems Networks and Translational Research – Insights into Inflammation (BioSNTR-II),” at South Dakota State University (SDSU), Brookings, SD. Our research objective is to improve human health by advancing the understanding of molecular, cellular and tissue-level mechanisms of inflammation research via multi-disciplinary approaches. The overarching hypothesis is that intracellular regulatory events are governed by cell-cell communication across the macrophage, stromal and lymphatic axes during the inflammatory response and its resolution. Junior research project leaders, mentored by senior faculty, define the three research projects of BioSNTR-II in the areas of: macrophage cell biology in inflammation, the role or primary cilia in regulating lymphangiogenesis in inflammation and regulation of tumor necrosis factor signaling and cell death pathways. These projects will be supported by two cutting-edge research cores in (1) transcriptome sequencing, analysis and model development (Transcriptome and Network Analyses Core) and (2) CRISPR- based gene editing and Integrated Microscopy and Gene Evaluation (CRISPR-IMAGE). In addition, an Administrative Core is proposed to support the fiscal and personnel management, implementation, oversight and evaluation of both the research projects and the cores. The synergy and integration of these components has been carefully planned to maximize impact while supporting training, professional development, and the career potential of a cadre of bright, promising basic researchers. The Center will achieve success through the following aims: (1) Develop and manage a thriving environment for inflammation research at SDSU, (2) Establish new Research Cores to expand and enhance biomedical research at SDSU, and (3) Guide center performance and sustainability with assessment and advisory board input.

项目概要-总体 该提案的目标是一个协调、协同和综合的COBRE研究计划，称为 “生物系统网络和转化研究-炎症的见解（BioSNTR-II），”在南 达科他州立大学（SDSU），布鲁金斯，SD。我们的研究目标是改善人类健康， 促进对炎症研究的分子、细胞和组织水平机制的理解， 多学科方法。最重要的假设是，细胞内的调节事件是由 通过在炎症过程中穿过巨噬细胞、基质和淋巴轴的细胞-细胞通讯， 的反应和解决。初级研究项目负责人，由资深教师指导，定义了三个 BioSNTR-II在以下领域的研究项目：巨噬细胞生物学在炎症中的作用或主要 纤毛在调节炎症中的淋巴管生成和调节肿瘤坏死因子信号和细胞 死亡之路这些项目将得到以下两个前沿研究核心的支持：（1）转录组 测序、分析和模型开发（转录组和网络分析核心）和（2）CRISPR- 基于基因编辑和集成显微镜和基因评估（CRISPR-IMAGE）。此外， 行政核心拟支持财政和人事管理、执行、监督 以及对研究项目和核心的评价。这些组成部分的协同作用和整合 经过精心策划，以最大限度地发挥影响，同时支持培训，专业发展， 一批聪明有为的基础研究人员的职业潜力。该中心将通过以下方式取得成功： 以下目标：（1）开发和管理SDSU炎症研究的繁荣环境，（2） 建立新的研究中心，以扩大和加强SDSU的生物医学研究，以及（3）指导中心 评估和咨询委员会的投入。