Augmenting Implanted Neuroprosthetics with Targeted Health Monitoring for Spinal Cord Injury - the LIFELINE

通过针对脊髓损伤的有针对性的健康监测增强植入式神经假体 - LIFELINE

基本信息

  • 批准号:
    10594006
  • 负责人:
  • 金额:
    $ 65.94万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-01 至 2025-03-31
  • 项目状态:
    未结题

项目摘要

Abstract Summary This proposal involves the development of an implanted health monitoring device, the "Lifeline" device, which senses health-related parameters, including temperature, electrocardiogram, photoplethysmogram, inertial measurement, and acoustic signals. We propose to enhance our existing modular neuroprosthetic system, the "Networked Neuroprosthesis" (NNP), with the Lifeline device, creating a comprehensive health monitoring system. The NNP System has already begun clinical evaluation in individuals with SCI for providing motor function, but currently lacks health monitoring capability. We are designing the Lifeline device as an integral component of the NNP system because the NNP system provides an existing source of implanted power, significant processing capacity, wireless data transmission, data storage, and an array of existing modules (electrical stimulation, biopotential recording, temperature sensing, inertial sensing). Thus the NNP system provides a platform for implementing and evaluating the benefits of implanted health monitoring while minimizing the development costs and regulatory hurdles. As designed, the Lifeline component adds minimal additional risk with respect to surgical implantation and system operation. An exciting anticipated outcome of the Lifeline-enhanced NNP System is the capacity to provide advanced warning regarding the top causes of increased mortality in individuals with SCI, enabling earlier detection and medical intervention that may ultimately increase overall life expectancy. The causes of early mortality include pneumonia, urinary tract infection (UTI), pulmonary embolism (PE), and autonomic dysreflexia (AD), which are unique to, or more prevalent in, people with SCI (particularly tetraplegia). The addition of the Lifeline device to the NNP System is the first step towards an implantable "life-saving neuroprosthesis". The overall benefit of the Lifeline-enhanced NNP System for SCI is twofold: 1) the high expectation of a functional benefit from the motor neuroprosthesis (original NNP System), and 2) the potential life-extending features of the implanted health monitoring (Lifeline). At the completion of this project, we anticipate having a single modular system that will be capable of providing both improved health and improved function for anyone with SCI, thus prolonging life while, at the same time, increasing independence and quality of life.
摘要摘要 这项提议涉及开发一种植入型健康监测设备,即“生命线” 该设备可以感知与健康相关的参数,包括体温、心电图、 光体积图、惯性测量和声学信号。我们建议加强我们现有的 模块化神经假体系统,“网络神经假体”(NNP),与生命线设备,创造 全面的健康监测体系。NNP系统已经在#年开始临床评估 脊髓损伤患者提供运动功能,但目前缺乏健康监测能力。我们是 将生命线装置设计为NNP系统的一个组成部分,因为NNP系统提供 现有的植入电源、强大的处理能力、无线数据传输、数据 存储和一系列现有模块(电刺激、生物电势记录、温度 传感、惯性传感)。因此,NNP系统提供了实施和评估 植入健康监测的好处,同时最大限度地减少开发成本和监管障碍。 正如设计的那样,生命线组件增加的外科植入和 系统运行。 生命线增强型NNP系统的一个令人兴奋的预期结果是能够提供 关于脊髓损伤患者死亡率上升的主要原因的高级警告,使更早 最终可能延长总体预期寿命的检测和医疗干预。早产的原因 死亡率包括肺炎、尿路感染(UTI)、肺栓塞(PE)和自主神经 反射障碍(AD),是脊髓损伤(尤其是四肢瘫痪)患者所特有的或更为普遍的疾病。这个 将生命线装置添加到NNP系统是朝着可植入的“救命”迈出的第一步 生命线增强的NNP系统治疗脊髓损伤的总体益处是两方面的:1)高 对运动神经假体(原始NNP系统)的功能益处的期望,以及2) 植入健康监测的潜在延长寿命功能(生命线)。在完成这项工作后 项目,我们预计将有一个单一的模块化系统,将能够提供改善的健康 改善了任何患有脊髓损伤的人的功能,从而延长了生命,同时增加了 独立性和生活质量。

项目成果

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KEVIN L. KILGORE其他文献

KEVIN L. KILGORE的其他文献

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{{ truncateString('KEVIN L. KILGORE', 18)}}的其他基金

Beekeeper Administrative Core for COSMIIC HORNET
COSMIIC HORNET 的养蜂人管理核心
  • 批准号:
    10701810
  • 财政年份:
    2022
  • 资助金额:
    $ 65.94万
  • 项目类别:
Beekeeper Administrative Core for COSMIIC HORNET
COSMIIC HORNET 的养蜂人管理核心
  • 批准号:
    10549467
  • 财政年份:
    2022
  • 资助金额:
    $ 65.94万
  • 项目类别:
Augmenting Implanted Neuroprosthetics with Targeted Health Monitoring for Spinal Cord Injury - the LIFELINE
通过针对脊髓损伤的有针对性的健康监测增强植入式神经假体 - LIFELINE
  • 批准号:
    10279756
  • 财政年份:
    2021
  • 资助金额:
    $ 65.94万
  • 项目类别:
Augmenting Implanted Neuroprosthetics with Targeted Health Monitoring for Spinal Cord Injury - the LIFELINE
通过针对脊髓损伤的有针对性的健康监测增强植入式神经假体 - LIFELINE
  • 批准号:
    10436372
  • 财政年份:
    2021
  • 资助金额:
    $ 65.94万
  • 项目类别:
Enhanced Modular Neuroprosthesis for the Restoration of Function in Neurological Injury or Disease
用于恢复神经损伤或疾病功能的增强型模块化神经假体
  • 批准号:
    9361985
  • 财政年份:
    2017
  • 资助金额:
    $ 65.94万
  • 项目类别:
Enhanced Modular Neuroprosthesis for the Restoration of Function in Neurological Injury or Disease
用于恢复神经损伤或疾病功能的增强型模块化神经假体
  • 批准号:
    9978580
  • 财政年份:
    2017
  • 资助金额:
    $ 65.94万
  • 项目类别:
Phase 2 study of the NNP for Grasp and Trunk in SCI: IDEG140225-11-13-2014
SCI 中抓握和躯干 NNP 的 2 期研究:IDEG140225-11-13-2014
  • 批准号:
    10915381
  • 财政年份:
    2016
  • 资助金额:
    $ 65.94万
  • 项目类别:
Phase 2 study of the NNP for Grasp and Trunk in SCI: IDEG140225-11-13-2014
SCI 中抓握和躯干 NNP 的 2 期研究:IDEG140225-11-13-2014
  • 批准号:
    9007402
  • 财政年份:
    2016
  • 资助金额:
    $ 65.94万
  • 项目类别:
Phase 2 study of the NNP for Grasp and Trunk in SCI: IDEG140225-11-13-2014
SCI 中抓握和躯干 NNP 的 2 期研究:IDEG140225-11-13-2014
  • 批准号:
    9352751
  • 财政年份:
    2016
  • 资助金额:
    $ 65.94万
  • 项目类别:
Kilohertz Frequency Alternating Current Spinal Cord Stimulation for Chronic Pain Relief
千赫兹频率交流脊髓刺激可缓解慢性疼痛
  • 批准号:
    8961952
  • 财政年份:
    2015
  • 资助金额:
    $ 65.94万
  • 项目类别:

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