Augmenting Implanted Neuroprosthetics with Targeted Health Monitoring for Spinal Cord Injury - the LIFELINE

通过针对脊髓损伤的有针对性的健康监测增强植入式神经假体 - LIFELINE

• 批准号: 10594006
• 负责人: KEVIN L. KILGORE
• 金额: $ 65.94万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594006
• 关键词: Acceleration; Acoustics; Applications Grants; Autonomic Dysreflexia; Autonomic nervous system; Benefits and Risks; Biomedical Engineering; Blood Vessels; Body Temperature; Cause of Death; Clinical Research; Computer software; Data; Data Storage and Retrieval; Development; Devices; Disease; Early Diagnosis; Electric Stimulation; Electrocardiogram; Electronics; Event; Foundations; Future; Goals; Guidelines; Health; Health Status; Human; Implant; Individual; Intervention; Life; Life Expectancy; Measurement; Measures; Mechanics; Medical; Monitor; Motor; Operative Surgical Procedures; Optics; Outcome; Output; Persons; Pneumonia; Populations at Risk; Pulmonary Embolism; Quadriplegia; Quality of life; Relative Risks; Research Project Grants; Risk; Risk-Benefit Assessment; Signal Transduction; Source; Specific qualifier value; Spinal cord injury; System; Temperature; Temperature Sense; Testing; Time; Urinary tract infection; cost; data exchange; design; early onset; expectation; functional improvement; health data; implantable device; implantation; improved; in vitro testing; in vivo; insight; monitoring device; mortality; multimodality; neuroprosthesis; operation; prototype; research clinical testing; sensor; sound; surgical risk; wireless

Abstract Summary This proposal involves the development of an implanted health monitoring device, the "Lifeline" device, which senses health-related parameters, including temperature, electrocardiogram, photoplethysmogram, inertial measurement, and acoustic signals. We propose to enhance our existing modular neuroprosthetic system, the "Networked Neuroprosthesis" (NNP), with the Lifeline device, creating a comprehensive health monitoring system. The NNP System has already begun clinical evaluation in individuals with SCI for providing motor function, but currently lacks health monitoring capability. We are designing the Lifeline device as an integral component of the NNP system because the NNP system provides an existing source of implanted power, significant processing capacity, wireless data transmission, data storage, and an array of existing modules (electrical stimulation, biopotential recording, temperature sensing, inertial sensing). Thus the NNP system provides a platform for implementing and evaluating the benefits of implanted health monitoring while minimizing the development costs and regulatory hurdles. As designed, the Lifeline component adds minimal additional risk with respect to surgical implantation and system operation. An exciting anticipated outcome of the Lifeline-enhanced NNP System is the capacity to provide advanced warning regarding the top causes of increased mortality in individuals with SCI, enabling earlier detection and medical intervention that may ultimately increase overall life expectancy. The causes of early mortality include pneumonia, urinary tract infection (UTI), pulmonary embolism (PE), and autonomic dysreflexia (AD), which are unique to, or more prevalent in, people with SCI (particularly tetraplegia). The addition of the Lifeline device to the NNP System is the first step towards an implantable "life-saving neuroprosthesis". The overall benefit of the Lifeline-enhanced NNP System for SCI is twofold: 1) the high expectation of a functional benefit from the motor neuroprosthesis (original NNP System), and 2) the potential life-extending features of the implanted health monitoring (Lifeline). At the completion of this project, we anticipate having a single modular system that will be capable of providing both improved health and improved function for anyone with SCI, thus prolonging life while, at the same time, increasing independence and quality of life.

抽象概括 这项建议涉及发展一种植入式健康监测装置，即“生命线”。 设备，它感测与健康相关的参数，包括温度，心电图， 光体积描记图、惯性测量和声学信号。我们建议加强现有的 模块化神经假体系统，“网络神经假体”（NNP），与生命线设备，创造 全面的健康监测系统。NNP系统已经开始临床评估， 提供运动功能，但目前缺乏健康监测能力。我们 将生命线设备设计为NNP系统的组成部分，因为NNP系统提供了 现有的植入电源、显著的处理能力、无线数据传输、数据 存储和现有模块阵列（电刺激、生物电位记录、温度 感测、惯性感测）。因此，NNP系统提供了一个平台，用于实施和评估 植入健康监测的好处，同时最大限度地减少开发成本和监管障碍。 按照设计，Lifeline组件在手术植入方面增加的额外风险最小， 系统操作。 生命线增强型NNP系统的一个令人兴奋的预期成果是提供以下能力： 关于SCI患者死亡率增加的主要原因的提前警告， 检测和医疗干预，最终可能会增加整体预期寿命。早期的原因 死亡率包括肺炎、尿路感染（UTI）、肺栓塞（PE）和自主神经系统疾病。 反射障碍（AD），这是SCI患者（特别是四肢瘫痪）特有的或更普遍的。的 在NNP系统中增加生命线装置是迈向植入式“救生”的第一步 神经假体”。生命线增强的NNP系统对SCI的总体益处是双重的：1）高 运动神经假体（原始NNP系统）的功能受益预期，以及2） 植入式健康监测（Lifeline）的潜在寿命延长功能。在完成此 项目，我们预计有一个单一的模块化系统，将能够提供改善健康 并改善任何SCI患者的功能，从而延长寿命，同时增加 独立性和生活质量。