Augmenting Implanted Neuroprosthetics with Targeted Health Monitoring for Spinal Cord Injury - the LIFELINE

通过针对脊髓损伤的有针对性的健康监测增强植入式神经假体 - LIFELINE

• 批准号: 10279756
• 负责人: KEVIN L. KILGORE
• 金额: $ 69.82万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10279756
• 关键词: Acceleration; Acoustics; Applications Grants; Autonomic Dysreflexia; Autonomic nervous system; Benefits and Risks; Biomedical Engineering; Blood Vessels; Body Temperature; Cause of Death; Clinical Research; Computer software; Data; Data Storage and Retrieval; Development; Devices; Disease; Early Diagnosis; Electric Stimulation; Electrocardiogram; Event; Foundations; Future; Goals; Guidelines; Health; Health Status; Human; Implant; In Vitro; Individual; Intervention; Life; Life Expectancy; Measurement; Measures; Mechanics; Medical; Monitor; Motor; Operative Surgical Procedures; Optics; Outcome; Output; Pneumonia; Populations at Risk; Pulmonary Embolism; Quadriplegia; Quality of life; Relative Risks; Research Project Grants; Risk; Risk-Benefit Assessment; Savings; Signal Transduction; Source; Spinal cord injury; System; Temperature; Temperature Sense; Testing; Time; Urinary tract infection; Wireless Technology; cost; data exchange; design; early onset; expectation; health data; implantable device; implantation; improved; improved functioning; in vivo; insight; monitoring device; mortality; multimodality; neuroprosthesis; operation; prototype; research clinical testing; sensor; sound; surgical risk

Abstract Summary This proposal involves the development of an implanted health monitoring device, the "Lifeline" device, which senses health-related parameters, including temperature, electrocardiogram, photoplethysmogram, inertial measurement, and acoustic signals. We propose to enhance our existing modular neuroprosthetic system, the "Networked Neuroprosthesis" (NNP), with the Lifeline device, creating a comprehensive health monitoring system. The NNP System has already begun clinical evaluation in individuals with SCI for providing motor function, but currently lacks health monitoring capability. We are designing the Lifeline device as an integral component of the NNP system because the NNP system provides an existing source of implanted power, significant processing capacity, wireless data transmission, data storage, and an array of existing modules (electrical stimulation, biopotential recording, temperature sensing, inertial sensing). Thus the NNP system provides a platform for implementing and evaluating the benefits of implanted health monitoring while minimizing the development costs and regulatory hurdles. As designed, the Lifeline component adds minimal additional risk with respect to surgical implantation and system operation. An exciting anticipated outcome of the Lifeline-enhanced NNP System is the capacity to provide advanced warning regarding the top causes of increased mortality in individuals with SCI, enabling earlier detection and medical intervention that may ultimately increase overall life expectancy. The causes of early mortality include pneumonia, urinary tract infection (UTI), pulmonary embolism (PE), and autonomic dysreflexia (AD), which are unique to, or more prevalent in, people with SCI (particularly tetraplegia). The addition of the Lifeline device to the NNP System is the first step towards an implantable "life-saving neuroprosthesis". The overall benefit of the Lifeline-enhanced NNP System for SCI is twofold: 1) the high expectation of a functional benefit from the motor neuroprosthesis (original NNP System), and 2) the potential life-extending features of the implanted health monitoring (Lifeline). At the completion of this project, we anticipate having a single modular system that will be capable of providing both improved health and improved function for anyone with SCI, thus prolonging life while, at the same time, increasing independence and quality of life.

摘要摘要 该建议涉及开发植入的健康监测设备，即“生命线” 设备，其中感应与健康相关的参数，包括温度，心电图， 光解释图，惯性测量和声信号。我们建议增强我们现有的 模块化神经假体系统，“网络神经假体”（NNP），带有生命线设备，创建 全面的健康监测系统。 NNP系统已经开始在 具有SCI提供运动功能的人，但目前缺乏健康监测能力。我们是 将生命线设备设计为NNP系统的组成部分，因为NNP系统提供 现有的植入力来源，大量处理能力，无线数据传输，数据 存储和一系列现有模块（电刺激，生物电位记录，温度 传感，惯性感应）。因此，NNP系统提供了实施和评估的平台 植入健康监测的好处，同时最大程度地减少开发成本和监管障碍。 按照设计，生命线组件在手术植入和 系统操作。 生命线增强NNP系统的令人兴奋的预期结果是提供的能力 关于SCI患者死亡率增加的最高原因的高级警告，以前 检测和医疗干预最终可能会增加总体预期寿命。早期的原因 死亡率包括肺炎，尿路感染（UTI），肺栓塞（PE）和自主神经 肌反应症（AD），其独有或更普遍的SCI患者（尤其是四肢瘫痪）。这 在NNP系统中增加生命线设备是迈向可植入的“挽救生命的第一步 神经假体“。 对运动神经假体（原始NNP系统）的功能益处的期望，2） 植入健康监测（生命线）的潜在延长生命的特征。完成此过程 项目，我们预计拥有一个单个模块化系统，该系统将能够提供改善的健康 并改善了SCI的任何人的功能，从而延长了寿命 独立性和生活质量。