Administrative Core

行政核心

• 批准号: 10596708
• 负责人: PEI ZHONG
• 金额: $ 4.03万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10596708
• 关键词: Ablation; Address; Benign; Clinical; Clinical Research; Clinical Treatment; Collaborations; Communities; Consultations; Data Scientist; Development; Development Plans; Disease; Dust; Educational workshop; Ensure; Fiber; Frequencies; Future; Goals; Health Expenditures; Holmium; In Situ; Injury to Kidney; Knowledge; Laser Lithotripsy; Lasers; Lead; Liquid substance; Mentored Clinical Scientist Development Program; Mentors; Mentorship; Methods; Nanotechnology; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; Outcome; Patients; Play; Positioning Attribute; Prevalence; Procedures; Program Development; Public Health; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Role; SECTM1 gene; Sampling; Science; Structure; Talents; Technology; Thulium; Time; Tissues; Toxic effect; Training; Treatment outcome; Universities; Ureteroscopy; Urinary Calculi; Urology; Work; absorption; career; career development; cost; data sharing; experience; improved; innovation; member; multidisciplinary; nanomaterials; nanoparticle; novel strategies; operation; programs; theories; tissue injury; tool; treatment choice; urologic

ADMINISTRATIVE CORE (AC) PROJECT SUMMARY/ABSTRACT Urinary stone disease (USD) is the second most costly urologic condition in the US, with an annual healthcare expenditure of more than $2 billion. Ureteroscopy (URS) via laser lithotripsy (LL) is the treatment of choice for USD. Recently, the introduction of high power/high frequency Holmium (Ho): YAG lasers and Thulium Fiber Laser (TFL) has fundamentally altered the clinical mode of operation in LL. Contemporary LL is often performed using dusting and pop-dusting modes that pulverize stone to dust in situ without the need for fragment extraction. However, there is an unmet need to develop approaches that can address some of the challenges of dusting and pop-dusting in order to significantly improve the clinical treatment outcome regardless of stone composition, shorten the procedure time, and lessen the risk of tissue injury. The proposed Duke FORWARD P20 Urology Center (Duke FORWARD Center) will tackle some of the most pressing problems in treating USD with LL. The Center's Research Project (RP) will focus on modifying the fluid medium to enhance the inherent cavitation or photothermal ablation mechanism for stone ablation during another critical clinical procedure, called pop-dusting, so that the treatment efficiency can be improved, while the procedure time and potentially collateral tissue damage will be reduced. The RP will be led by Po-Chun Hsu, a promising junior investigator new to USD research with expertise in nanotechnology for heat and thermal management that will be central to the RP's strategy. The primary goal of Duke FORWARD's Administrative Core (AC) is to guide and support the efforts of the Center's RP Team to successfully conduct their project and help prepare them to apply for future R01s. The Specific Aims of the AC are to: (1) Facilitate productive collaborations among the RP Team and with the broader CAIRIBU research community; and (2) implement a career development plan for RP PI Po-Chun Hsu for him to gain experience and mastery in USD research knowledge and technical capabilities. If the aims of the AC are achieved, the RP Team will have successfully accomplished the aims of their RP and will be in a position to submit one or more follow-on R01s by Year 3 of the proposed Center. In supporting the Center, the AC will facilitate innovative research with the potential to benefit millions of USD patients worldwide and will have introduced this talented new USD research team to the NIDDK-sponsored CAIRIBU benign urology research community.

行政核心（AC）项目总结/摘要 尿结石病（USD）是美国第二昂贵的泌尿系统疾病，每年需要支付医疗费用 支出超过20亿元。经激光碎石术（LL）的输尿管镜检查（URS）是治疗 USD.最近，高功率/高频率钬（Ho）：YAG激光器和Thu光纤的推出， 激光（TFL）从根本上改变了LL的临床操作模式。当代LL经常被表演 使用除尘和爆破除尘模式，使碎石就地除尘，而不需要碎片提取。 然而，在开发能够解决粉尘化的一些挑战的方法方面， 和爆破除尘以显著改善临床治疗结果而不考虑结石成分， 缩短手术时间，减少组织损伤的风险。申报的杜克FORWARD P20泌尿科 中心（杜克前进中心）将解决一些最紧迫的问题，在治疗美元与LL。的 中心的研究项目（RP）将集中在修改流体介质，以提高固有的空化或 在另一个关键的临床过程中用于结石消融的光热消融机制，称为爆破除尘， 从而可以提高治疗效率，而手术时间和潜在的侧支组织 损害将减少。研究小组将由许宝俊（Po-Chun Hsu）领导，他是一位新加入市署的有前途的初级研究员 研究与专门知识的纳米技术的热量和热管理，这将是核心的RP的 战略杜克FORWARD行政核心（AC）的主要目标是指导和支持 中心的RP团队成功地进行他们的项目，并帮助他们准备申请未来的R 01。 AC的具体目标是：（1）促进RP团队之间以及与 更广泛的CAIRIBU研究社区;（2）为RP PI Po-Chun Hsu实施职业发展计划 为他获得经验和掌握美元的研究知识和技术能力。如果目标的 AC的实现，RP团队将成功地完成其RP的目标，并将处于一个位置， 提交一个或多个后续R 01的第3年的拟议中心。在支持中心的过程中，AC将 促进创新研究，有可能使全球数百万美元的患者受益，并将 介绍了这一有才华的新的USD研究团队到NIDDK赞助的CAIRIBU良性泌尿学研究 社区