Expanding UAMS Research Capacity to Establish a Center for Animal Models of Infection and Disease (CAMID)

扩大 UAMS 研究能力，建立感染和疾病动物模型中心 (CAMID)

• 批准号: 10596926
• 负责人: Daniel E Voth
• 金额: $ 797.5万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-19 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10596926
• 关键词: Animal Disease Models; Animal Housing; Animal Model; Animals; Arkansas; Basic Science; Biomedical Research; COVID-19; Collaborations; Communicable Diseases; Disease; Disease Outbreaks; Ensure; Faculty Recruitment; Fostering; Funding; Future; Future Teacher; Goals; Health; Human; Immune response; Infection; Infectious Diseases Research; Institution; Laboratories; Medical; Phase; Plague; Population Study; Public Health; Q Fever; Research; Research Personnel; Safety; Science; Security; Specimen; Study models; Training Programs; Tuberculosis; Underserved Population; United States National Institutes of Health; Universities; animal facility; biocontainment facility; biosafety level 3 facility; emerging pathogen; graduate student; pandemic disease; pathogen; programs; response; rural underserved; square foot; student training; tissue culture

The University of Arkansas for Medical Sciences (UAMS) is an Institution of Emerging Excellence in a small state with a large rural, underserved population that suffers disproportionately from infectious diseases. UAMS has committed to expanding infectious disease basic research through faculty recruitments but has outgrown current space for high-security biocontainment and animal facilities. This C06 proposal will support the first of 2 phases of renovation of the animal and biosafety level-3 (BSL-3) facilities in Biomedical Research Building I at UAMS and establish the Center for Animal Models of Infection and Disease (CAMID). The CAMID will allow safe and efficient research on highly infectious pathogens, ensure rapid response to new disease outbreaks, and provide new research opportunities by accomplishing the following goals: Goal 1) Expanding capacity for highly infectious disease research. UAMS currently supports 4 research programs that study tuberculosis, plague, COVID-19, and Q fever in a small BSL-3 facility. These renovations will permit needed expansion of these programs and establishment of new pathogen studies by adding 552 sq. ft. of wet laboratory space and doubling animal housing capacity. Goal 2) Establishing a facility for rapid responses to outbreaks and population studies. BSL-2 and -3 space (330 sq. ft. total) termed the Pandemic Response and Public Health Laboratory (PRPHL) will be established to respond to outbreaks needing increased safety precautions and allow new population-based studies. This facility will be optimized for tissue culture and handling human specimens. Goal 3) Expanding the animal facility to study the host response to disease. The UAMS animal facility must be expanded to accommodate researchers' needs. The space proposed for BSL-3 expansion currently houses animals, requiring renovation of new space to recapture this square footage. Proposed renovations will increase animal room and procedural space, expand cage wash capacity, and increase the animal facility by 8,450 sq. ft. Impact of renovations. The proposed increase in animal room space will support current NIH-funded projects and animal model studies by future faculty, and these renovations will enhance UAMS's impact on Arkansans' health by fostering new collaborations with public health researchers. In addition, UAMS has a robust graduate student program that trains students in infectious disease laboratories to become future researchers. The proposed renovations will increase opportunities to train students in animal models of disease.

阿肯色大学医学科学大学（UAMS）是一个在一个小小的新兴的机构中 乡村大量，服务不足的人口遭受传染病的不成比例。 UAMS 致力于通过教师招募来扩大传染病基础研究 当前的高安全性生物内在和动物设施的空间。该C06提案将支持2个 生物医学研究大楼I的动物和生物安全3级（BSL-3）设施的翻新阶段 UAM并建立感染和疾病动物模型中心（CAMID）。凸轮将允许 对高度感染性病原体的安全有效研究，确保对新疾病暴发的快速反应， 并通过实现以下目标来提供新的研究机会： 目标1）扩大高度传染病研究的能力。 UAMS目前支持4个研究 在小型BSL-3设施中研究结核病，鼠疫，Covid-19和Q发烧的程序。这些翻新 将允许通过添加552平方英尺来扩展这些计划并建立新的病原体研究。 湿实验室空间的英尺和动物住房能力加倍。 目标2）建立一个对爆发和人口研究快速反应的设施。 BSL -2和-3 空间（总计330平方英尺）称为大流行反应，公共卫生实验室（PRPHL）将是 建立以应对需要增加安全预防措施的爆发并允许新的基于人群的爆发 研究。该设施将用于组织培养和处理人类标本。 目标3）扩大动物设施以研究宿主对疾病的反应。 UAMS动物设施 必须扩展以满足研究人员的需求。目前为BSL-3扩展的空间 容纳动物，需要翻新新的空间以重新捕获这一平方英尺。拟议的翻新将 增加动物室和程序空间，扩大笼子清洗能力，并通过 8,450平方英尺 翻新的影响。拟议的动物室空间增加将支持当前的NIH资助项目 以及未来教师的动物模型研究，这些翻新将增强UAM对阿肯色州的影响 通过与公共卫生研究人员建立新的合作来进行健康。此外，UAMS具有强大的毕业生 学生计划，培训传染病实验室的学生成为未来的研究人员。这 拟议的翻新将增加培训学生疾病动物模型的机会。