Expanding UAMS Research Capacity to Establish a Center for Animal Models of Infection and Disease (CAMID)

阿肯色医学大学(UAMS)是一所规模较小的新兴卓越学院 该州有大量农村人口，没有得到足够的服务，而且患有不成比例的传染病。UAMS 致力于通过招聘教员来扩大传染病基础研究，但已经超过了 目前用于高度安全的生物围栏和动物设施的空间。此C06提案将支持第2项中的第一项 生物医学研究大楼I的动物和生物安全3级(BSL-3)设施的翻新阶段 并建立感染和疾病动物模型中心(CAMID)。CAMID将允许 对高传染性病原体进行安全高效的研究，确保对新的疾病爆发做出快速反应， 并通过实现以下目标提供新的研究机会： 目标1)扩大高度传染性疾病研究的能力。UAMS目前支持4项研究 在BSL-3的一个小型设施中研究结核病、鼠疫、新冠肺炎和Q热的项目。这些翻修工程 将允许对这些计划进行必要的扩展，并通过增加552平方英尺来建立新的病原体研究。 英国《金融时报》潮湿的实验室空间和加倍的动物收容所容量。 目标2)建立一个对疫情和人口研究作出快速反应的设施。BSL-2和-3 空间(330平方英尺)英国《金融时报》被称为大流行应对和公共卫生实验室(PRPHL)将是 建立的目的是应对需要加强安全预防措施的疫情，并允许以新的人口为基础 学习。该设施将针对组织培养和处理人体标本进行优化。 目标3)扩大动物设施以研究宿主对疾病的反应。UAMS动物设施 必须进行扩展，以适应研究人员的需求。目前建议的BSL-3扩建空间 饲养动物，需要翻新新空间才能夺回这一平方英尺的面积。拟议的翻修工程将 增加动物房间和程序空间，扩大笼子洗涤能力，增加动物设施 8450平方英尺英国《金融时报》 翻新的影响。拟议增加的动物室空间将支持目前由美国国立卫生研究院资助的项目 和动物模型研究，这些翻新将加强UAMS对阿肯色州的影响 促进与公共卫生研究人员的新合作。此外，UAMS拥有一名健壮的毕业生 学生计划，在传染病实验室培训学生成为未来的研究人员。这个 拟议的翻修将增加对学生进行疾病动物模型培训的机会。

The University of Arkansas for Medical Sciences (UAMS) is an Institution of Emerging Excellence in a small state with a large rural, underserved population that suffers disproportionately from infectious diseases. UAMS has committed to expanding infectious disease basic research through faculty recruitments but has outgrown current space for high-security biocontainment and animal facilities. This C06 proposal will support the first of 2 phases of renovation of the animal and biosafety level-3 (BSL-3) facilities in Biomedical Research Building I at UAMS and establish the Center for Animal Models of Infection and Disease (CAMID). The CAMID will allow safe and efficient research on highly infectious pathogens, ensure rapid response to new disease outbreaks, and provide new research opportunities by accomplishing the following goals: Goal 1) Expanding capacity for highly infectious disease research. UAMS currently supports 4 research programs that study tuberculosis, plague, COVID-19, and Q fever in a small BSL-3 facility. These renovations will permit needed expansion of these programs and establishment of new pathogen studies by adding 552 sq. ft. of wet laboratory space and doubling animal housing capacity. Goal 2) Establishing a facility for rapid responses to outbreaks and population studies. BSL-2 and -3 space (330 sq. ft. total) termed the Pandemic Response and Public Health Laboratory (PRPHL) will be established to respond to outbreaks needing increased safety precautions and allow new population-based studies. This facility will be optimized for tissue culture and handling human specimens. Goal 3) Expanding the animal facility to study the host response to disease. The UAMS animal facility must be expanded to accommodate researchers' needs. The space proposed for BSL-3 expansion currently houses animals, requiring renovation of new space to recapture this square footage. Proposed renovations will increase animal room and procedural space, expand cage wash capacity, and increase the animal facility by 8,450 sq. ft. Impact of renovations. The proposed increase in animal room space will support current NIH-funded projects and animal model studies by future faculty, and these renovations will enhance UAMS's impact on Arkansans' health by fostering new collaborations with public health researchers. In addition, UAMS has a robust graduate student program that trains students in infectious disease laboratories to become future researchers. The proposed renovations will increase opportunities to train students in animal models of disease.