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Mental Health of Mothers of Children with CL/P and Incidental Findings from Whole Genome Sequencing

CL/P 儿童母亲的心理健康状况以及全基因组测序的偶然发现

基本信息

批准号：
10594077
负责人：
Azeez Butali
金额：
$ 13.35万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2023-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10594077
关键词：
Address Adult Affect Africa African Appearance Behavioral Bioethics Blood Caring Child Childhood Cleft Lip Cleft Palate Cleft lip with or without cleft palate Clinical Collaborations Communities Complex Data Economics Environmental Risk Factor Equipment and supply inventories Ethiopia Ethnic Origin Etiology Face Family Family member Friends Gatekeeping Genetic Genetic Risk Geographic Locations Goals Health Health Personnel Incidental Findings Infanticide Iowa Life Live Birth Longitudinal Studies Low Prevalence Medical Mendelian disorder Mental Health Morbidity - disease rate Mothers Oral Surgical Procedures Parents Participant Phenotype Podoconiosis Prevalence Provider Psychiatry Quality of life Questionnaires Reporting Resource-limited setting Risk Role Sickle Cell Anemia Societies Stigmatization Training Triad Acrylic Resin Universities congenital anomaly design experience genome sequencing health of the mother insight member mortality oral surgery specialty orofacial cleft pressure psychosocial research study social culture social stigma therapy design trait whole genome

项目摘要

PROJECT SUMMARY The focus of this project is to identify “Mental Health” issues in mothers of children with CL/P in the presence of incidental findings from whole genome sequencing (WGS) of cleft triads supported by R01 DE028300. WGS provides an opportunity for the identification of “incidental findings” that indicate an increased risk for traits like sickle cell anemia and other single gene disorders that may have immediate medical implications for those in the study or their family members. We plan to determine the mental health experiences and quality of life in mother and child dyads with cleft abnormalities and to evaluate levels of behavioral difficulty in children with an orofacial cleft and relationship with quality of life and the mental health difficulty in their mothers in the presence of incidental findings. This is both a bioethics research study and capacity building opportunity in bioethics. This study will be led by Dr. Butali at the University of Iowa in collaboration with Dr. Yewande Oshodi and Dr. Adeyemo at the University of Lagos.

项目摘要该项目的重点是确定儿童CL/P母亲的“心理健康”问题，裂三联体的全基因组测序（WGS）中偶然发现的存在由R 01 DE 028300支持。WGS提供了一个机会，这些发现表明，镰状细胞性贫血和其他单基因遗传病等特征的风险增加，可能对研究对象或其家庭有直接医学影响的疾病成员我们计划确定母亲的心理健康经历和生活质量，儿童畸形的二对儿，并评估儿童的行为困难水平，口面裂及其与生活质量和心理健康困难的关系母亲在偶然发现的存在。这既是一项生物伦理学研究，生物伦理学能力建设的机会。这项研究将由密歇根大学的Butali博士领导。爱荷华州与拉各斯大学的Yewande Oshodi博士和Adeyemo博士合作。